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An optical sensor for the determination of digoxin in serum samples based on a molecularly imprinted polymer membrane.

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dc.contributor.authorDurand Alegría, Jesús Senén
dc.contributor.authorPaniagua González, Gema::virtual::2768::600
dc.contributor.authorFernández Hernando, Pilar::virtual::2769::600
dc.contributor.authorPaniagua González, Gema
dc.contributor.authorFernández Hernando, Pilar
dc.contributor.authorPaniagua González, Gema
dc.contributor.authorFernández Hernando, Pilar
dc.contributor.authorPaniagua González, Gema
dc.contributor.authorFernández Hernando, Pilar
dc.date.accessioned2024-05-20T11:18:23Z
dc.date.available2024-05-20T11:18:23Z
dc.date.issued2009-04
dc.description.abstractThis paper reports the synthesis and testing of a molecularly imprinted polymer membrane for digoxin analysis. Digoxin-specific bulk polymer was obtained by the UV initiated co-polymerisation of methacrylic acid and ethylene glycol dimethacrylate in acetonitrile as porogen. After extracting the template analyte, the ground polymer particles were mixed with plasticizer polyvinyl chloride to form a MIP membrane. A reference polymer membrane was prepared from the same mixture of monomers but with no template. The resultant membrane morphologies were examined by scanning electron microscopy. The imprinted membrane was tested as the recognition element in a digoxin-sensitive fluorescence sensor; sensor response was measured using standard solutions of digoxin at concentrations of up to 4 × 10−3 mg L−1. The detection limit was 3.17 × 10−5 mg L−1. Within- and between-day relative standard deviations RSD (n = 5) were in the range 4.5–5.5% and 5.5–6.5% respectively for 0 and 1 × 10−3 mg L−1 digoxin concentrations. A selectivity study showed that compounds of similar structure to digoxin did not significantly interfere with detection for interferent concentrations at 10, 30 and 100 times higher than the digoxin concentration. This simply manufactured MIP membrane showed good recognition characteristics, a high affinity for digoxin, and provided satisfactory results in analyses of this analyte in human serum.en
dc.description.versionversión final
dc.identifier.doihttps://doi.org/10.1016/j.aca.2009.02.023
dc.identifier.issn0003-2670 - eISSN 1873-4324
dc.identifier.urihttps://hdl.handle.net/20.500.14468/11608
dc.journal.titleAnalytica Chimica Acta
dc.journal.volume638
dc.language.isoen
dc.publisherElsevier
dc.relation.centerFacultad de Ciencias
dc.relation.departmentCiencias Analíticas
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject.keywordsMolecularly imprinted polymer
dc.subject.keywordsAffinity membrane
dc.subject.keywordsDigoxin
dc.subject.keywordsOrganic sample analysis
dc.titleAn optical sensor for the determination of digoxin in serum samples based on a molecularly imprinted polymer membrane.es
dc.typejournal articleen
dc.typeartículoes
dspace.entity.typePublication
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