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The effects of feminization hormone therapy on the brain of transgender women: A hypothesis

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dc.contributor.authorZubiaurre-Elorza, Leire
dc.contributor.authorUribe, Carme
dc.contributor.authorMarcos, Alberto
dc.contributor.authorFernández, Rosa
dc.contributor.authorPásaro, Eduardo
dc.contributor.authorRodríguez Del Cerro, María Cruz
dc.contributor.authorBurke, Sarah M.
dc.contributor.authorGuillamón Fernández, Antonio
dc.contributor.funderEuropean Commission
dc.contributor.funderAgencia estatal de Investigación (España)
dc.date.accessioned2025-10-29T10:31:39Z
dc.date.available2025-10-29T10:31:39Z
dc.date.issued2025-12-30
dc.description.abstractGender-affirming hormone therapy (GAHT) is a medical treatment used to help trans- gender individuals align their physical appearance with their gender identity. GAHT in transgender women (TW) has been found to lead to a reduction in brain tissue with an expansion of the ventricles. We discuss an animal model studying the effects of GAHT that suggests dehydration of brain tissue and an alteration in the relative con- centration of brain metabolites. We hypothesize that estradiol, acting on astrocytes, alters cerebral blood flow, water metabolism, and metabolite concentration and argue that these changes could explain the higher risk of stroke observed n GAHT-treated TW compared to untreated cisgender men. Future studies should clarify the mecha- nisms underlying the brain tissue changes induced by GAHT.en
dc.description.sponsorshipEuropean Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie fellowship, Grant/Award Number: 888692; Ministry of Science and Innovation, Grant/Award Numbers: PDI21-127547NB-C21, PDI21-127547NB-C22en
dc.description.versionversión original
dc.identifier.issn-
dc.identifier.urihttps://hdl.handle.net/20.500.14468/30677
dc.journal.title-
dc.language.isoen
dc.relation.centerFacultad de Psicología
dc.relation.departmentPsicobiología
dc.relation.projectidinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-127547NB-C21/ES/ENDOFENOTIPOS CEREBRALES EN ADOLESCENTES TRANSGENERO ANTES Y DESPUES DEL TRATAMIENTO CON BLOQUEADORES DE LA PUBERTAD
dc.relation.projectidinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-127547NB-C22/ES/EFECTOS GENETICOS Y EPIGENETICOS DEL TRATAMIENTO CON BLOQUEADORES DE LA PUBERTAD EN ADOLESCENTES TRANSGENERO
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject6199 Otras especialidades psicológicas (especificar)
dc.subject.keywordsastrocytesen
dc.subject.keywordsestradiolen
dc.subject.keywordsfractional anisotropyen
dc.subject.keywordsMRIen
dc.subject.keywordstransgender womenen
dc.titleThe effects of feminization hormone therapy on the brain of transgender women: A hypothesisen
dc.typeartículoes
dc.typejournal articleen
dspace.entity.typePublication
relation.isAuthorOfPublication41fb37a1-b419-4bc7-9156-9f17e4bb6ca2
relation.isAuthorOfPublicationfe1fe829-effa-4eee-8cde-8b382270a8f4
relation.isAuthorOfPublication.latestForDiscovery41fb37a1-b419-4bc7-9156-9f17e4bb6ca2
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