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The Effect of Methylphenidate on the Microstructure of Schedule-Induced Polydipsia in an animal model of ADHD

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dc.contributor.authorDaniels, Carter W.
dc.contributor.authorSanabria, Federico
dc.contributor.authorIbias Martín, Javier
dc.contributor.authorMiguens Vázquez, Miguel
dc.contributor.authorPellón Suárez de Puga, Ricardo
dc.date.accessioned2024-05-20T11:50:25Z
dc.date.available2024-05-20T11:50:25Z
dc.date.issued2017-08-30
dc.description.abstractSchedule-induced polydipsia (SIP) was established in spontaneously hypertensive rats (SHR), Wistar Kyoto rats (WKY), and Wistar rats, using a multiple fixed-time (FT) schedule of food delivery, with 30- and 90-s components. Thereafter, animals were exposed to methylphenidate (MPH; 2.5 mg/kg/d) for six consecutive SIP sessions. A test to assess possible sensitization effects was also conducted four days after termination of the drug treatment. At baseline, FT 90-s produced longer and more frequent drinking episodes in SHR than in WKY. An analysis of the distribution of inter-lick intervals revealed that drinking was organized in bouts, which were shorter in SHR than in WKY. Across strains and schedules, MPH shifted drinking episodes towards the beginning of inter-food intervals, which may reflect a stimulant effect on SIP. MPH transiently reduced the frequency of drinking episodes in WKY in FT 30-s, and more permanently reduced the frequency of licking bouts in Wistar rats. MPH also increased the length of licking bouts in Wistar rats. Overall, SHR displayed a hyperactive-like pattern of drinking (frequent but short bouts), which 2.5 mg/kg MPH appears to reduce in WKY and Wistar but not in SHR rats. It appears that therapeutic effects of MPH on hyperactive-like SIP require higher doses in SHR relative to control strains.en
dc.description.versionversión final
dc.identifier.doihttp://doi.org/10.1016/j.bbr.2017.06.048
dc.identifier.issn0166-4328
dc.identifier.urihttps://hdl.handle.net/20.500.14468/12619
dc.journal.titleBehavioural Brain Research
dc.journal.volume333
dc.language.isoen
dc.publisherElsevier
dc.relation.centerFacultad de Psicología
dc.relation.departmentMetodología de las Ciencias del Comportamiento
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject.keywordsSchedule-induced polydipsia
dc.subject.keywordsMethylphenidate
dc.subject.keywordsAttention-deficit hyperactivity disorder Bouts
dc.subject.keywordsSpontaneously hypertensive rat
dc.subject.keywordsWistar Kyoto rats
dc.titleThe Effect of Methylphenidate on the Microstructure of Schedule-Induced Polydipsia in an animal model of ADHDes
dc.typejournal articleen
dc.typeartículoes
dspace.entity.typePublication
relation.isAuthorOfPublication309c25b3-8ac4-4106-9ad3-4a441098fae9
relation.isAuthorOfPublication5329dfae-47ff-4e74-8de7-9daab9d7a92c
relation.isAuthorOfPublication8edbde84-9307-47aa-9ef8-5e85de175df6
relation.isAuthorOfPublication.latestForDiscovery309c25b3-8ac4-4106-9ad3-4a441098fae9
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