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Genistein during Development Alters Differentially the Expression of POMC in Male and Female Rats

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dc.contributor.authorFernández García, José Manuel
dc.contributor.authorTezanos, Patricia
dc.contributor.authorPino Osuna, María José
dc.contributor.authorCarrillo Urbano, Beatriz
dc.contributor.authorCollado Guirao, Paloma
dc.date.accessioned2024-05-20T11:52:43Z
dc.date.available2024-05-20T11:52:43Z
dc.date.issued2021
dc.description.abstractPhytoestrogens are considered beneficial for health, but some studies have shown that they may cause adverse effects. This study investigated the effects of genistein administration during the second week of life on energy metabolism and on the circuits regulating food intake. Two different genistein doses, 10 or 50 g/g, were administered to male and female rats from postnatal day (P) 6 to P13. Physiological parameters, such as body weight and caloric intake, were then analyzed at P90. Moreover, proopiomelanocortin (POMC) expression in the arcuate nucleus (Arc) and orexin expression in the dorsomedial hypothalamus (DMH), perifornical area (PF) and lateral hypothalamus (LH) were studied. Our results showed a delay in the emergence of sex differences in the body weight in the groups with higher genistein doses. Furthermore, a significant decrease in the number of POMC-immunoreactive (POMC-ir) cells in the Arc in the two groups of females treated with genistein was observed. In contrast, no alteration in orexin expression was detected in any of the structures analyzed in either males or females. In conclusion, genistein can modulate estradiol’s programming actions on the hypothalamic feeding circuits differentially in male and female rats during development.en
dc.description.versionversión publicada
dc.identifier.doihttps://doi.org/10.3390/metabo11050293
dc.identifier.issn2218-1989
dc.identifier.urihttps://hdl.handle.net/20.500.14468/12664
dc.journal.titleMetabolites
dc.journal.volume11
dc.language.isoen
dc.publisherMDPI
dc.relation.centerFacultad de Psicología
dc.relation.departmentPsicobiología
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subject.keywordsgenistein
dc.subject.keywordsproopiomelanocortin
dc.subject.keywordsarcuate nucleus
dc.subject.keywordssex differences
dc.subject.keywordsrats
dc.titleGenistein during Development Alters Differentially the Expression of POMC in Male and Female Ratses
dc.typejournal articleen
dc.typeartículoes
dspace.entity.typePublication
relation.isAuthorOfPublicationdfe3de35-dfac-45e6-82b7-29469afe631b
relation.isAuthorOfPublication1c9559e7-aba1-4505-8acb-8a3813368a63
relation.isAuthorOfPublication.latestForDiscoverydfe3de35-dfac-45e6-82b7-29469afe631b
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