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The effect of HF-rTMS over the left DLPFC on stress regulation as measured by cortisol and heart rate variability

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dc.contributor.authorPulopulos, Matias M.
dc.contributor.authorSchmausser, Maximilian
dc.contributor.authorDe Smet, Stefanie
dc.contributor.authorVanderhasselt, Marie Anne
dc.contributor.authorBaliyan, Shishir
dc.contributor.authorVenero Núñez, César
dc.contributor.authorBaeken, Chris
dc.contributor.authorRaedt, Rudi De
dc.date.accessioned2025-01-28T18:10:00Z
dc.date.available2025-01-28T18:10:00Z
dc.date.issued2020-06-13
dc.descriptionThe registered version of this article, first published in Hormones and Behavior, is available online at the publisher's website: Elsevier, https://doi.org/10.1016/j.yhbeh.2020.104803
dc.descriptionLa versión registrada de este artículo, publicado por primera vez en Hormones and Behavior, está disponible en línea en el sitio web del editor: Elsevier, https://doi.org/10.1016/j.yhbeh.2020.104803
dc.description.abstractThe prefrontal cortex, and especially the Dorsolateral Prefrontal Cortex (DLPFC), plays an inhibitory role in the regulation of the Hypothalamic-Pituitary-Adrenal (HPA) axis under stressful situations. Moreover, recent evidence suggests that a sustained DLPFC activation is associated with adaptive stress regulation in anticipation of a stressful event, leading to a reduced stress-induced amygdala response, and facilitating the confrontation with the stressor. However, studies using experimental manipulation of the activity of the DLPFC before a stressor are scarce, and more research is needed to understand the specific role of this brain area in the stress-induced physiological response. This pre-registered study investigated the effect on stress regulation of a single excitatory high frequency (versus sham) repetitive transcranial magnetic stimulation (HF-rTMS) session over the left DLPFC applied before the Trier Social Stress Test in 75 healthy young women (M = 21.05, SD = 2.60). Heart rate variability (HRV) and salivary cortisol were assessed throughout the experimental protocol. The active HF-rTMS and the sham group showed a similar cognitive appraisal of the stress task. No differences in HRV were observed during both the anticipation and the actual confrontation with the stress task and therefore, our results did not reflect DLPFC-related adaptive anticipatory adjustments. Importantly, participants in the active HF-rTMS group showed a lower cortisol response to stress. The effect of left prefrontal HF-rTMS on the stress system provides further critical experimental evidence for the inhibitory role played by the DLPFC in the regulation of the HPA axis.en
dc.description.versionversión final
dc.identifier.citationMatias M. Pulopulos, Maximilian Schmausser, Stefanie De Smet, Marie-Anne Vanderhasselt, Shishir Baliyan, César Venero, Chris Baeken, Rudi De Raedt, The effect of HF-rTMS over the left DLPFC on stress regulation as measured by cortisol and heart rate variability, Hormones and Behavior, Volume 124, 2020, 104803
dc.identifier.issn0018-506X
dc.identifier.urihttps://hdl.handle.net/20.500.14468/25608
dc.journal.titleHormones and Behavior
dc.journal.volume124
dc.language.isoen
dc.publisherElsevier
dc.relation.centerFacultades y escuelas::Facultad de Psicología
dc.relation.departmentPsicobiología
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject24 Ciencias de la Vida::2410 Biología humana
dc.subject61 Psicología
dc.subject.keywordsHF-rTMSen
dc.subject.keywordsHPA axisen
dc.subject.keywordsstress,en
dc.subject.keywordscortisolen
dc.subject.keywordsHRVen
dc.titleThe effect of HF-rTMS over the left DLPFC on stress regulation as measured by cortisol and heart rate variabilityen
dc.typeartículoes
dc.typejournal articleen
dspace.entity.typePublication
relation.isAuthorOfPublication8a052a0d-95db-493f-8166-b6e711ef1d17
relation.isAuthorOfPublicationa021663c-0586-44a7-898c-3dc7811295ac
relation.isAuthorOfPublication.latestForDiscovery8a052a0d-95db-493f-8166-b6e711ef1d17
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