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G protein-coupled estrogen receptor immunoreactivity in the rat hypothalamus is widely distributed in neurons, astrocytes and oligodendrocytes, fluctuates during the estrous cycle and is sexually dimorphic

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dc.contributor.authorMarraudino, Marilena
dc.contributor.authorCarrillo Urbano, Beatriz
dc.contributor.authorBonaldo, Brigitta
dc.contributor.authorLlorente, Ricardo
dc.contributor.authorCampioli, Elia
dc.contributor.authorGarate, Iciar
dc.contributor.authorPinos Sánchez, María Elena
dc.contributor.authorGarcia Segura, Luis
dc.contributor.authorCollado Guirao, Paloma
dc.contributor.authorGrassi, Daniela
dc.date.accessioned2024-12-30T08:16:06Z
dc.date.available2024-12-30T08:16:06Z
dc.date.issued2021-06-29
dc.descriptionEste es el manuscrito aceptado del artículo. La versión registrada fue publicada por primera vez en Neuroendocrinology, 111(7):660-677. FI: 6.804; Q1, está disponible en línea en el sitio web del editor: https://doi.org/10.1159/000509583. This is the accepted manuscript of the article. The proprietary version was first published in Neuroendocrinology, 111(7):660-677. IF: 6,804; Q1, is available online at the publisher's website: https://doi.org/10.1159/000509583.
dc.description.abstractIntroduction: The membrane-associated G protein-coupled estrogen receptor 1 (GPER) mediates the regulation by estradiol of arginine-vasopressin immunoreactivity in the supraoptic and paraventricular hypothalamic nuclei of female rats and is involved in the estrogenic control of hypothalamic regulated functions, such as food intake, sexual receptivity, and lordosis behavior. Objective: To assess GPER distribution in the rat hypothalamus. Methods: GPER immunoreactivity was assessed in different anatomical subdivisions of five selected hypothalamic regions of young adult male and cycling female rats: the arcuate nucleus, the lateral hypothalamus, the paraventricular nucleus, the supraoptic nucleus, and the ventromedial hypothalamic nucleus. GPER immunoreactivity was colocalized with NeuN as a marker of mature neurons, GFAP as a marker of astrocytes, and CC1 as a marker of mature oligodendrocytes. Results: GPER immunoreactivity was detected in hypothalamic neurons, astrocytes, and oligodendrocytes. Sex and regional differences and changes during the estrous cycle were detected in the total number of GPER-immunoreactive cells and in the proportion of neurons, astrocytes, and oligodendrocytes that were GPER-immunoreactive. Conclusions: These findings suggest that estrogenic regulation of hypothalamic function through GPER may be different in males and females and may fluctuate during the estrous cycle in females.es
dc.description.versionversión final
dc.identifier.citationMarraudino M., Carrillo B., Bonaldo B., Llorente R., Campioli E., Garate I., Pinos H., Garcia-Segura LM., Collado P., Grassi D. (2020). G protein-coupled estrogen receptor immunoreactivity in the rat hypothalamus is widely distributed in neurons, astrocytes and oligodendrocytes, fluctuates during the estrous cycle and is sexually dimorphic. Neuroendocrinology, 111:660-677. FI: 6.804; Q1; https://doi.org/10.1159/000509583
dc.identifier.doihttps://doi.org/10.1159/000509583
dc.identifier.issn0028-3835; e-ISSN: 1423-0194
dc.identifier.urihttps://hdl.handle.net/20.500.14468/25066
dc.journal.issue7
dc.journal.titleNeuroendocrinology
dc.journal.volume111
dc.language.isoen
dc.page.final677
dc.page.initial660
dc.publisherKarger International
dc.relation.centerFacultades y escuelas::Facultad de Psicología
dc.relation.departmentPsicobiología
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject61 Psicología
dc.subject.keywordsArcuate nucleusen
dc.subject.keywordslateral hypothalamusen
dc.subject.keywordsparaventricular nucleusen
dc.subject.keywordssupraoptic nucleusen
dc.subject.keywordsventromedial hypothalamusen
dc.titleG protein-coupled estrogen receptor immunoreactivity in the rat hypothalamus is widely distributed in neurons, astrocytes and oligodendrocytes, fluctuates during the estrous cycle and is sexually dimorphicen
dc.typeartículoes
dc.typejournal articleen
dspace.entity.typePublication
relation.isAuthorOfPublicationdfe3de35-dfac-45e6-82b7-29469afe631b
relation.isAuthorOfPublication71657c77-6882-40f7-a5c9-03b3da3a0f26
relation.isAuthorOfPublication1c9559e7-aba1-4505-8acb-8a3813368a63
relation.isAuthorOfPublication.latestForDiscoverydfe3de35-dfac-45e6-82b7-29469afe631b
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