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Effects of heroin self-administration and forced withdrawal on the expression of genes related to the mTOR network in the basolateral complex of the amygdala of male Lewis rats

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dc.contributor.authorUcha Tortuero, Marcos
dc.contributor.authorRoura Martínez, David
dc.contributor.authorSantos Toscano, Raquel
dc.contributor.authorCapellán, Roberto
dc.contributor.authorAmbrosio Flores, Emilio
dc.contributor.authorHiguera Matas, Alejandro
dc.date.accessioned2025-01-10T14:49:37Z
dc.date.available2025-01-10T14:49:37Z
dc.date.issued2022-04-25
dc.descriptionThe registered version of this article, first published in Psychopharmacology, is available online at the publisher's website: Springer Nature, https://doi.org/10.1007/s00213-022-06144-2
dc.descriptionLa versión registrada de este artículo, publicado por primera vez en Psychopharmacology, está disponible en línea en el sitio web del editor: Springer Nature, https://doi.org/10.1007/s00213-022-06144-2
dc.description.abstractRationale The development of substance use disorders involves long-lasting adaptations in specific brain areas that result in an elevated risk of relapse. Some of these adaptations are regulated by the mTOR network, a signalling system that integrates extracellular and intracellular stimuli and modulates several processes related to plasticity. While the role of the mTOR network in cocaine- and alcohol-related disorders is well established, little is known about its participation in opiate use disorders. Objectives To use a heroin self-administration and a withdrawal protocol that induce incubation of heroin-seeking in male rats and study the associated effects on the expression of several genes related to the mTOR system and, in the specific case of Rictor, its respective translated protein and phosphorylation. Results We found that heroin self-administration elicited an increase in the expression of the genes Igf1r, Igf2r, Akt2 and Gsk3a in the basolateral complex of the amygdala, which was not as evident at 30 days of withdrawal. We also found an increase in the expression of Rictor (a protein of the mTOR complex 2) after heroin self-administration compared to the saline group, which was occluded at the 30-day withdrawal period. The activation levels of Rictor, measured by the phosphorylation rate, were also reduced after heroin self-administration, an effect that seemed more apparent in the protracted withdrawal group. Conclusions These results suggest that heroin self-administration under extended access conditions modifies the expression profile of activators and components of the mTOR complexes and show a putative irresponsive mTOR complex 2 after withdrawal from heroin use.en
dc.description.versionversión final
dc.identifier.citationMarcos Ucha, David Roura-Martínez, Raquel Santos-Toscano, Roberto Capellán, Emilio Ambrosio, Alejandro Higuera-Matas. Effects of heroin self-administration and forced withdrawal on the expression of genes related to the mTOR network in the basolateral complex of the amygdala of male Lewis rats. Psychopharmacology. (239) 2022. 2559-2571
dc.identifier.doihttps://doi.org/10.1007/s00213-022-06144-2
dc.identifier.issn1432-2072
dc.identifier.urihttps://hdl.handle.net/20.500.14468/25196
dc.journal.titlePsychopharmacology
dc.journal.volume239
dc.language.isoen
dc.page.final2571
dc.page.initial2559
dc.publisherSpringer Nature
dc.relation.centerFacultades y escuelas::Facultad de Psicología
dc.relation.departmentPsicobiología
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.es
dc.subject24 Ciencias de la Vida::2490 Neurociencias
dc.subject24 Ciencias de la Vida::2410 Biología humana
dc.subject61 Psicología
dc.subject.keywordsmTORen
dc.subject.keywordsRictoren
dc.subject.keywordsheroinen
dc.subject.keywordsbasolateral complex of the amygdalaen
dc.subject.keywordsincubation of seekingen
dc.titleEffects of heroin self-administration and forced withdrawal on the expression of genes related to the mTOR network in the basolateral complex of the amygdala of male Lewis ratsen
dc.typeartículoes
dc.typejournal articleen
dspace.entity.typePublication
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relation.isAuthorOfPublicationddd20842-ce7c-4040-b326-f8c8f245bd14
relation.isAuthorOfPublication21ea02fc-c9b2-4c02-b6fa-50b005e149b8
relation.isAuthorOfPublication.latestForDiscovery2752467e-b928-4d03-b841-9e77e45d1711
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