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Exposure to increased levels of estradiol during development can have long-term effects on the response to undernutrition in female rats

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dc.contributor.authorDíaz González, Francisca
dc.contributor.authorChowen, Julie A.
dc.contributor.authorPino Osuna, María José
dc.contributor.authorCarrillo Urbano, Beatriz
dc.contributor.authorCollado Guirao, Paloma
dc.date.accessioned2024-06-11T15:15:31Z
dc.date.available2024-06-11T15:15:31Z
dc.date.issued2016-11
dc.description.abstractObjectives: Undernutrition during development alters the expression of peptides that control energy expenditure and feeding behavior. Estrogens can also modulate these peptides. Here we analyzed whether early postnatal administration of estradiol modulates the effects of undernutrition on neuroendocrine parameters in adult female Wistar rats. Methods: Control rats were fed a control diet. Undernourished pups were submitted to a restricted diet with half of the undernourished rats receiving 0.4 mg/kg s.c. of estradiol benzoate (EB) from postnatal day (P) 6 until P13. Quantitative real-time PCR was performed to determine expression in the hypothalamus of Agouti-related peptide (AgRP), proopiomelanocortin (POMC), neuropeptide Y (NPY) and cocaine- and amphetamine-regulated transcript (CART). Plasma estradiol, testosterone and adiponectin levels were measured by ELISA. Total and acylated ghrelin levels were measured in plasma by RIA. Results: Undernourishment decreased body weight, fat mass, plasma leptin and insulin levels and hypothalamic POMC mRNA levels. An increase in orexigenic signals AgRP and NPY mRNA levels, and in plasma adiponectin levels were found in undernourished animals. Early postnatal treatment with EB to undernourished female rats reversed the effects of undernutrition on adult hypothalamic POMC mRNA levels. In addition, neonatal EB treatment to undernourished females significantly decreased adult plasma testosterone, estradiol and acylated ghrelin levels. Discussion: Our results suggest that increased estradiol during a critical period of development has the capacity to modulate the alterations that undernutrition produces on energy metabolism.en
dc.identifier.doihttps://doi.org/10.1179/1476830515Y.0000000012
dc.identifier.issn1476-8305
dc.identifier.urihttps://hdl.handle.net/20.500.14468/22421
dc.journal.issue9
dc.journal.titleNutritional Neuroscience
dc.journal.volume19
dc.language.isoen
dc.publisherTaylor and Francis Group
dc.relation.centerFacultades y escuelas::Facultad de Psicología
dc.relation.departmentPsicobiología
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject.keywordsProtein restriction
dc.subject.keywordsEstradiol
dc.subject.keywordsOrexinergic and anorexinergic neuropeptides
dc.subject.keywordsMetabolic factors
dc.subject.keywordsPCR
dc.subject.keywordsRat
dc.titleExposure to increased levels of estradiol during development can have long-term effects on the response to undernutrition in female ratses
dc.typejournal articleen
dc.typeartículoes
dspace.entity.typePublication
relation.isAuthorOfPublicationdfe3de35-dfac-45e6-82b7-29469afe631b
relation.isAuthorOfPublication1c9559e7-aba1-4505-8acb-8a3813368a63
relation.isAuthorOfPublication.latestForDiscoverydfe3de35-dfac-45e6-82b7-29469afe631b
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