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The long-term effects of adolescent Δ9-tetrahydrocannabinol on brain structure and function assessed through neuroimaging techniques in male and female rats

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dc.contributor.authorOrihuel Menéndez, Javier
dc.contributor.authorCapellán, Roberto
dc.contributor.authorCasquero Veiga, Marta
dc.contributor.authorSoto Montenegro, María Luisa
dc.contributor.authorDesco, Manuel
dc.contributor.authorOteo Vives, Marta
dc.contributor.authorIbáñez Moragues, Marta
dc.contributor.authorMagro Calvo, Natalia
dc.contributor.authorLuján, Víctor M.
dc.contributor.authorMorcillo, Miguel Ángel
dc.contributor.authorAmbrosio Flores, Emilio
dc.contributor.authorHiguera Matas, Alejandro
dc.contributor.orcidhttps://orcid.org/0000-0001-9586-0684
dc.contributor.orcidhttps://orcid.org/0000-0003-0306-7916
dc.date.accessioned2025-01-10T13:23:09Z
dc.date.available2025-01-10T13:23:09Z
dc.date.issued2023-06-03
dc.descriptionThe registered version of this article, first published in European Neuropsychopharmacology, is available online at the publisher's website: EDITOR, https://doi.org/10.1016/j.euroneuro.2023.05.005
dc.descriptionLa versión registrada de este artículo, publicado por primera vez en European Neuropsychopharmacology, está disponible en línea en el sitio web del editor: EDITOR, https://doi.org/10.1016/j.euroneuro.2023.05.005
dc.description.abstractSeveral studies performed on human subjects have examined the effects of adolescent cannabis consumption on brain structure or function using brain imaging techniques. However, the evidence from these studies is usually heterogenous and affected by several confounding variables. Animal models of adolescent cannabinoid exposure may help to overcome these difficulties. In this exploratory study, we aim to increase our understanding of the protracted effects of adolescent Δ9-tetrahydrocannabinol (THC) in rats of both sexes using magnetic resonance (MR) to obtain volumetric data, assess grey and white matter microstructure with diffusion tensor imaging (DTI) and measure brain metabolites with 1H-MR spectroscopy (MRS); in addition, we studied brain function using positron emission tomography (PET) with 2-deoxy-2-[18F]fluoro-d-glucose as the tracer. THC-exposed rats exhibited volumetric and microstructural alterations in the striatum, globus pallidus, lateral ventricles, thalamus, and septal nuclei in a sex-specific manner. THC administration also reduced fractional anisotropy in several white matter tracts, prominently in rostral sections, while in vivo MRS identified lower levels of cortical choline compounds. THC-treated males had increased metabolism in the cerebellum and olfactory bulb and decreased metabolism in the cingulate cortex. By contrast, THC-treated females showed hypermetabolism in a cluster of voxels comprising the entorhinal piriform cortices and in the cingulate cortex. These results indicate that mild THC exposure during adolescence leaves a lingering mark on brain structure and function in a sex-dependant manner. Some of the changes found here resemble those observed in human studies and highlight the importance of studying sex-specific effects in cannabinoid research.en
dc.description.versionversión publicada
dc.identifier.citationJavier Orihuel, Roberto Capellán Marta Casquero-Veiga María Luisa Soto-Montenegro , Manuel Desco , Marta Oteo-Vives, Marta Ibáñez-Moragues , Natalia Magro-Calvo , Víctor M Luján , Miguel Ángel Morcillo , Emilio Ambrosio , Alejandro Higuera-Matas. The long-term effects of adolescent Δ9-tetrahydrocannabinol on brain structure and function assessed through neuroimaging techniques in male and female rats. European Neuropsychopharmacology. (74) 2023 47-63
dc.identifier.doihttps://doi.org/10.1016/j.euroneuro.2023.05.005
dc.identifier.issn1873-7862
dc.identifier.urihttps://hdl.handle.net/20.500.14468/25194
dc.journal.titleEuropean Neuropsychopharmacology
dc.journal.volume74
dc.language.isoen
dc.page.final63
dc.page.initial47
dc.publisherElsevier
dc.relation.centerFacultades y escuelas::Facultad de Psicología
dc.relation.departmentPsicobiología
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject24 Ciencias de la Vida::2490 Neurociencias
dc.subject24 Ciencias de la Vida::2410 Biología humana
dc.subject61 Psicología
dc.subject.keywordsadolescenceen
dc.subject.keywordsMRIen
dc.subject.keywordsPETen
dc.subject.keywordsspectroscopyen
dc.subject.keywordsTHCen
dc.titleThe long-term effects of adolescent Δ9-tetrahydrocannabinol on brain structure and function assessed through neuroimaging techniques in male and female ratsen
dc.typeartículoes
dc.typejournal articleen
dspace.entity.typePublication
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relation.isAuthorOfPublicationddd20842-ce7c-4040-b326-f8c8f245bd14
relation.isAuthorOfPublication21ea02fc-c9b2-4c02-b6fa-50b005e149b8
relation.isAuthorOfPublication.latestForDiscoveryb845a12a-4363-4e14-b104-f3ac06d8b78a
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