Publicación:
Blocking of Estradiol Receptors ERα, ERβ and GPER During Development, Differentially Alters Energy Metabolism in Male and Female Rats

Vista sencilla de ítem
dc.contributor.authorDíaz González, Francisca
dc.contributor.authorChowen, Julie A.
dc.contributor.authorGrassi, Daniela
dc.contributor.authorPinos Sánchez, María Elena
dc.contributor.authorCarrillo Urbano, Beatriz
dc.contributor.authorCollado Guirao, Paloma
dc.date.accessioned2024-05-20T11:52:55Z
dc.date.available2024-05-20T11:52:55Z
dc.date.issued2020
dc.description.abstractEstradiol not only participates in the regulation of energy metabolism in adulthood, but also during the first stages of life as it modulates the alterations induced by under- and over-nutrition. The objectives of the present study were to determine: 1) If estradiol is involved in the normal programming of energy metabolism in rats; 2) If there is a specific window of time for this programming and 3) If males and females are differentially vulnerable to the action of this hormone. Estrogen receptors (ER) α, ERβ and GPER were blocked by their specific antagonists MPP, PHTPP and G15, respectively, from postnatal day (P) 1 (the day of birth) to P5 or from P5 to P13. Physiological parameters such as body weight, fat depots and caloric intake were then analysed at P90. Hypothalamic AgRP, POMC, MC4R, ERα, ERβ and GPER mRNA levels and plasma levels of estradiol, were also studied. We found that blocking ER receptors from P5 to P13 significantly decreases long-term body weight in males and hypothalamic POMC mRNA levels in females. The blocking of ERs from P1 to P5 only affected plasma estradiol levels in females. The present results indicate programming actions of estradiol from P5 to P13 on body weight in male and POMC expression in female rats and emphasize the importance of including both sexes in metabolic studies. It is necessary to unravel the mechanisms that underlie the actions of estradiol on food intake, both during development and in adulthood, and to determine how this programming differentially takes place in males and females.es
dc.description.versionversión publicada
dc.identifier.doihttps://doi.org/10.1016/j.neuroscience.2019.11.008
dc.identifier.issn1873-7544, 0306-4522
dc.identifier.urihttps://hdl.handle.net/20.500.14468/12668
dc.journal.titleNeuroscience
dc.journal.volume426
dc.language.isoen
dc.publisherElsevier
dc.relation.centerFacultad de Psicología
dc.relation.departmentPsicobiología
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.subject.keywordsestradiol receptor alpha (ERa)
dc.subject.keywordsestradiol receptor beta (ERb)
dc.subject.keywordsG-protein-coupled estrogen receptor (GPER)
dc.subject.keywordsenergy metabolism programming
dc.subject.keywordsPOMC
dc.subject.keywordssex differences
dc.titleBlocking of Estradiol Receptors ERα, ERβ and GPER During Development, Differentially Alters Energy Metabolism in Male and Female Ratses
dc.typejournal articleen
dc.typeartículoes
dspace.entity.typePublication
relation.isAuthorOfPublicationdfe3de35-dfac-45e6-82b7-29469afe631b
relation.isAuthorOfPublication1c9559e7-aba1-4505-8acb-8a3813368a63
relation.isAuthorOfPublication.latestForDiscoverydfe3de35-dfac-45e6-82b7-29469afe631b
Archivos
Bloque original
Mostrando 1 - 1 de 1
Miniatura
Nombre:
Collado_Guirao_Paloma_Blocking_of_Estradi.pdf
Tamaño:
378.77 KB
Formato:
Adobe Portable Document Format
Descargar
Colecciones
Artículos y papers