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Effects at molecular level of multi-walled carbon nanotubes (MWCNT) in Chironomus riparius (DIPTERA) aquatic larvae

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dc.contributor.authorMartínez Paz, Pedro
dc.contributor.authorNegri, Viviana
dc.contributor.authorEsteban Arranz, Adrián
dc.contributor.authorBallesteros García, Paloma
dc.contributor.authorMartínez Guitarte, José Luis
dc.contributor.authorMorales Camarzana, Consolación Mónica
dc.date.accessioned2024-05-20T11:28:26Z
dc.date.available2024-05-20T11:28:26Z
dc.date.issued2019-04
dc.description.abstractNowadays, due to the physical, chemical, electrical, thermal and mechanical properties of carbon nanotubes (CNT), its have been currently incorporated into biomedical products and they are employed in drug delivery drug administration, biosensor design, microbial treatments, consumer products, and new products containing CNT are expected in the future. CNT are hydrophobic and have a tendency to accumulate in sediments if they are released into aquatic ecosystems. Vertebrate studies have revealed concerns about the toxicity of carbon nanotubes, but there is very limited data on the toxic effects in aquatic invertebrate species. The aim of the present study is to determine the effects of MWCNT in Chironomus riparius at the molecular level, understanding its mode of action and analyzing the suitability of this species to monitor and assess risk of nanomaterials in aquatic ecosystems. To evaluate possible toxic effects caused by carbon nanotube environmental dispersion with regard to aquatic compartment, we study the mRNA levels of several related genes with DNA repairing mechanisms, cell stress response, cell apoptosis and cytoskeleton by Real-Time PCR and proposed a freshwater invertebrate C. riparius, which is a reference organism in aquatic toxicology. The obtained results show a transcriptional alteration of some genes included in this study, indicating that different cell processes are affected and providing one the first evidences in the mechanisms of action of MWCNT in invertebrates. Moreover, this data reinforces the need for further studies to assess the environmental risk of nanomaterial to prevent future damage to aquatic ecosystems.en
dc.description.versionversión publicada
dc.identifier.doihttps://doi.org/10.1016/j.aquatox.2019.01.017
dc.identifier.issn0166-445X; eISSN: 1879-1514
dc.identifier.urihttps://hdl.handle.net/20.500.14468/12062
dc.journal.titleAquatic Toxicology
dc.journal.volume209
dc.language.isoen
dc.publisherElsevier
dc.relation.centerFacultad de Ciencias
dc.relation.departmentFísica Matemática y de Fluídos
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0
dc.subject.keywordsDNA repair genes
dc.subject.keywordsCell apoptosis gene
dc.subject.keywordsCell stress response genes
dc.subject.keywordsCytoskeleton gene
dc.titleEffects at molecular level of multi-walled carbon nanotubes (MWCNT) in Chironomus riparius (DIPTERA) aquatic larvaees
dc.typejournal articleen
dc.typeartículoes
dspace.entity.typePublication
relation.isAuthorOfPublicationa078395f-9ae2-4e6a-b18c-2549d07bdea9
relation.isAuthorOfPublication700f9417-c7b6-45f0-a781-3b1b8ae73b9c
relation.isAuthorOfPublication.latestForDiscoverya078395f-9ae2-4e6a-b18c-2549d07bdea9
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