Persona: Nieto Gómez, Carla Isabel
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Nieto Gómez
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Publicación Effects of Curcuminoid Pyrazoles on Cancer Cells and on the Expression of Telomerase Related Genes(Wiley, 2016-07) Martí Centelles, Rosa; Falomir Ventura, Eva; Carda, Miguel; Cornago, María del Pilar; Claramunt, Rosa María; Nieto Gómez, Carla IsabelA group of 13 curcuminoid pyrazoles was investigated for their cytotoxicity on three tumoral cell lines (HT-29, MCF-7, and HeLa) and one non-tumoral human cell line (HEK-293). The values obtained were compared with those of curcumin. A subset of selected derivatives was also studied for their ability to downregulate expression of the hTERT and c-Myc genes, which are both involved in telomerase activity.Publicación A multinuclear magnetic resonance study of fluoro derivatives of hydroxybenzaldehydes(2015-06-06) Claramunt, Rosa María; Alkorta, Ibon; Elguero, J.; Sanz del Castillo, Dionisia; Nieto Gómez, Carla IsabelPublicación Curcumin Related 1,4-Diazepines: Regioselective Synthesis, Structure Analysis, Tautomerism, NMR Spectroscopy, X-ray Crystallography, Density Functional Theory and GIAO Calculations(Wiley, 2017-05-02) Andrade, Ana; Claramunt, Rosa María; Torralba, M. Carmen; Torres, M. Rosario; Alkorta, Ibon; Elguero, J.; Nieto Gómez, Carla Isabel; Sanz del Castillo, DionisiaThe reaction of 1,2-ethylenediamine with seven fluorinated β-diketones affords two different 1,4-diazepine series depending on the experimental conditions. Their structures as well as tautomerism have been established by 1H, 13C, 15N and 19F nuclear magnetic resonance in solution supported by density functional theory calculations at the B3LYP/6-311++G(d,p) level. The two compounds obtained from (E)-5-(2-fluoro-4-hydroxyphenyl)-1-phenylpent-4-ene-1,3-dione were analyzed by X-ray crystallography and studied by solid-state NMR.