Persona:
Venero Núñez, César

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ORCID
0000-0003-4879-3495
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Venero Núñez
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César
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20192
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Fecha de finalización: 2019 × Fecha de inicio: 2019 ×

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Mostrando 1 - 2 de 2
  • Miniatura
    Publicación
    Systemic administration of a fibroblast growth factor receptor 1 agonist rescues the cognitive deficit in aged socially isolated rats
    (Elsevier, 2019-03-29) Pereda Pérez, Inmaculada; Valencia Jiménez, Azucena; Baliyan, Shishir; Núñez, Ángel; Sanz García, Ancor; Rodríguez Fernández, Raquel; Esteban, José Antonio; Venero Núñez, César; Zamora Crespo, Berta; Elsevier; https://orcid.org/0000-0002-8013-4812; https://orcid.org/0000-0002-5024-5108
    Social isolation predominantly occurs in elderly people and it is strongly associated with cognitive decline. However, the mechanisms that produce isolation-related cognitive dysfunction during aging remain unclear. Here, we evaluated the cognitive, electrophysiological, and morphological effects of short- (4 weeks) and long-term (12 weeks) social isolation in aged male Wistar rats. Long-term but not short-term social isolation increased the plasma corticosterone levels and impaired spatial memory in the Morris water maze. Moreover, isolated animals displayed dampened hippocampal long-term potentiation in vivo, both in the dentate gyrus (DG) and CA1, as well as a specific reduction in the volume of the stratum oriens and spine density in CA1. Interestingly, social isolation induced a transient increase in hippocampal basic fibroblast growth factor (FGF2), whereas fibroblast growth factor receptor 1 (FGFR1) levels only increased after long-term isolation. Importantly, subchronic systemic administration of FGL, a synthetic peptide that activates FGFR1, rescued spatial memory in long-term isolated rats. These findings provide new insights into the neurobiological mechanisms underlying the detrimental effects on memory of chronic social isolation in the aged.
  • Miniatura
    Publicación
    Accuracy of verbal fluency tests in the discrimination of mild cognitive impairment and probable Alzheimer's disease in older Spanish monolingual individuals
    (Taylor and Francis Online, 2019-12-10) García Herranz, Sara; Díaz Mardomingo, María del Carmen; Venero Núñez, César; Peraita Adrados, Herminia
    The main objetive was to analyze the accuracy of different verbal fluency tests (VFTs) in discriminating cognitively healthy subjects from individuals with mild cognitive impairment (MCI) and probable Alzheimer’s disease (AD) in a cohort of older Spanish speaking adults. As a result, we aimed to identify the VFT that best predicts conversion from MCI to probable AD. 287 subjects: 170 controls (HC), 90 stable MCI and 27 patients with MCI that evolved into probable AD (MCI-AD) were assessed with a neuropsychological battery test and five VFTs. The animal fluency test produced the best differentiation of HC from MCI (p < .001), of HC from MCI-AD (p < .001) and of MCI from MCI-AD converters (p < .001), with sensitivities 98.8%, 98.8% and 75.6%, respectively. Logistic regression showed that the animal fluency test (p < 0.001) appears to be the most useful and neuropsychological VFT to predict conversion to probable dementia.