Persona: Zamora Crespo, Berta
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PublicaciĂłn Systemic administration of a fibroblast growth factor receptor 1 agonist rescues the cognitive deficit in aged socially isolated rats(Elsevier, 2019-03-29) Pereda PĂ©rez, Inmaculada; Valencia JimĂ©nez, Azucena; Baliyan, Shishir; NĂșñez, Ăngel; Sanz GarcĂa, Ancor; RodrĂguez FernĂĄndez, Raquel; Esteban, JosĂ© Antonio; Venero NĂșñez, CĂ©sar; Zamora Crespo, Berta; Elsevier; https://orcid.org/0000-0002-8013-4812; https://orcid.org/0000-0002-5024-5108Social isolation predominantly occurs in elderly people and it is strongly associated with cognitive decline. However, the mechanisms that produce isolation-related cognitive dysfunction during aging remain unclear. Here, we evaluated the cognitive, electrophysiological, and morphological effects of short- (4 weeks) and long-term (12 weeks) social isolation in aged male Wistar rats. Long-term but not short-term social isolation increased the plasma corticosterone levels and impaired spatial memory in the Morris water maze. Moreover, isolated animals displayed dampened hippocampal long-term potentiation in vivo, both in the dentate gyrus (DG) and CA1, as well as a specific reduction in the volume of the stratum oriens and spine density in CA1. Interestingly, social isolation induced a transient increase in hippocampal basic fibroblast growth factor (FGF2), whereas fibroblast growth factor receptor 1 (FGFR1) levels only increased after long-term isolation. Importantly, subchronic systemic administration of FGL, a synthetic peptide that activates FGFR1, rescued spatial memory in long-term isolated rats. These findings provide new insights into the neurobiological mechanisms underlying the detrimental effects on memory of chronic social isolation in the aged.