Persona:
Martínez Herrada, Antonio

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Martínez Herrada
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Antonio
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2023 - 20252
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Mostrando 1 - 2 de 2
  • Miniatura
    Publicación
    Socialization, and its modulation by sex, on the development and recovery of activity-based anorexia in rats
    (Elsevier, 2023-07-17) Martínez Herrada, Antonio; Paz Regidor, Ana María de; Pellón Suárez de Puga, Ricardo
    The activity-based anorexia (ABA) animal model has been used in the laboratory to study the role of excessive physical activity in the manifestation of anorexia nervosa (AN) in humans. Factors of social context are crucial in human health and the emergence of many psychological disorders, which have also been observed in studies using different mammal species that, like human beings, set their lives in groups. In the present study, the animals’ social condition was manipulated to observe the effect of socialization in ABA development, and the possible different influence of the variable sex on the phenomenon. Eighty Wistar Han rats were distributed into four male and four female groups with 10 subjects each, manipulating social conditions (group housing or social isolation) and physical activity (access or not to a running wheel). Throughout the procedure, all groups had food restricted to 1 h/day during the light period. Furthermore, ABA experimental groups with access to the running wheel had two periods of access to the wheel of 2 h each, one before and the other after the food period. In this experiment, socialized rats were less vulnerable to weight loss during the procedure, although there were no differences between the ABA groups. Moreover, social enrichment was shown to be an enabling variable of the animals’ recovery after their withdrawal from the procedure, with this effect being more pronounced in females. The results in this study suggest the need to further in the analysis of the role of socialization in the development of ABA.
  • Miniatura
    Publicación
    Temporal distribution of schedule-induced behavior depends on the essential value of the reinforcer
    (Wiley, 2025) Martínez Herrada, Antonio; Pellón Suárez de Puga, Ricardo; López Tolsa Gómez, Gabriela Eugenia
    The development of schedule-induced drinking depends on different variables affecting the food delivered at the end of the interfood interval. There are mixed results concerning the effects of varying magnitude and/or preference of different reinforcers in the development of schedule-induced drinking, with some studies showing higher levels and other studies showing lower levels of drinking. The purpose of this study was to observe how differences in preference for a flavor of equally nutritious food pellets influence the development and maintenance of schedule-induced drinking. Using the operant demand framework, four flavors of food pellets were compared to form two groups: one in which subjects would receive their most preferred flavor and another in which subjects would receive their least preferred flavor. In general, licking rates were lower and magazine-entering rates were higher when the preferred flavor was delivered regardless of the fixed-time schedule used. It is suggested that the value of the reinforcer has a larger influence on the immediately preceding behaviors, which will determine the distribution of competing responses in the interreinforcement intervals. These results are relevant to developing public policies that manipulate the taste of healthy food to increase its consumption.