Examinando por Autor "Carda, Miguel"

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    Publicación
    Effects of Curcuminoid Pyrazoles on Cancer Cells and on the Expression of Telomerase Related Genes
    (Wiley, 2016-07) Martí Centelles, Rosa; Falomir Ventura, Eva; Carda, Miguel; Cornago, Mª del Pilar; Nieto Gómez, Carla Isabel
    A group of 13 curcuminoid pyrazoles was investigated for their cytotoxicity on three tumoral cell lines (HT-29, MCF-7, and HeLa) and one non-tumoral human cell line (HEK-293). The values obtained were compared with those of curcumin. A subset of selected derivatives was also studied for their ability to downregulate expression of the hTERT and c-Myc genes, which are both involved in telomerase activity.