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Pérez Martín, Jorge

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0000-0002-3588-7233
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Pérez Martín
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Jorge
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2021 - 20222
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Autor: Díez Vegas, Francisco Javier × Fecha de inicio: 2020 ×

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Mostrando 1 - 2 de 2
  • Miniatura
    Publicación
    Cost-effectiveness analysis with unordered decisions
    (Elsevier, 2021-07) Díez Vegas, Francisco Javier; Luque Gallego, Manuel; Arias Calleja, Manuel; Pérez Martín, Jorge
    Introduction Cost-effectiveness analysis (CEA) is used increasingly in medicine to determine whether the health benefit of an intervention is worth the economic cost. Decision trees, the standard decision modeling technique for non-temporal domains, can only perform CEAs for very small problems. Influence diagrams can model much larger problems, but only when the decisions are totally ordered. Objective To develop a CEA method for problems with unordered or partially ordered decisions, such as finding the optimal sequence of tests for diagnosing a disease. Methods We explain how to model those problems using decision analysis networks (DANs), a new type of probabilistic graphical model, somewhat similar to Bayesian networks and influence diagrams. We present an algorithm for evaluating DANs with two criteria, cost and effectiveness, and perform some experiments to study its computational efficiency. We illustrate the representation framework and the algorithm using a hypothetical example involving two therapies and several tests and then present a DAN for a real-world problem, the mediastinal staging of non-small cell lung cancer. Results The evaluation of a DAN with two criteria, cost and effectiveness, returns a set of intervals for the willingness to pay, separated by incremental cost-effectiveness ratios (ICERs). The cost, the effectiveness, and the optimal intervention are specific for each interval, i.e., they depend on the willingness to pay. Conclusion Problems involving several unordered decisions can be modeled with DANs and evaluated in a reasonable amount of time. OpenMarkov, an open-source software tool developed by our research group, can be used to build the models and evaluate them using a graphical user interface.
  • Miniatura
    Publicación
    Teaching Probabilistic Graphical Models with OpenMarkov
    (MDPI, 2022-11-30) Díez Vegas, Francisco Javier; Arias Calleja, Manuel; Pérez Martín, Jorge; Luque Gallego, Manuel
    OpenMarkov is an open-source software tool for probabilistic graphical models. It has been developed especially for medicine, but has also been used to build applications in other fields and for tuition, in more than 30 countries. In this paper we explain how to use it as a pedagogical tool to teach the main concepts of Bayesian networks and influence diagrams, such as conditional dependence and independence, d-separation, Markov blankets, explaining away, optimal policies, expected utilities, etc., and some inference algorithms: logic sampling, likelihood weighting, and arc reversal. The facilities for learning Bayesian networks interactively can be used to illustrate step by step the performance of the two basic algorithms: search-and-score and PC.