Persona: Martín Aranda, Rosa María
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0000-0001-5628-8144
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Martín Aranda
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Rosa María
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Publicación Ordered mesoporous molecular sieves as active catalyts for the synthesis of 1,4-dihydropyridine derivatives(Elsevier, 2020-09-01) Calvino Casilda, Vanesa; Martín Aranda, Rosa MaríaResearch on heterocyclic compounds with biological and pharmacological activity continues to arouse great interest. The study of 1,4-dihydropyridines (1,4-DHPs) is of particular interest in the pharmaceutical field due to their important applications as calcium channel antagonists for the treatment of heart diseases. The implementation of novel heterogeneous catalysts to optimize Hantzsch synthesis, such as ordered mesoporous molecular sieves, is an efficient and eco-friendly proposal that still requires a lot of work. The remarkable features of ordered mesoporous molecular sieves, such as high surface area, tailored porosity, chemical and thermal stability, among others, turn these materials into powerful solid catalysts capable of selectively leading the synthesis of 1,4-DHPs. In addition, the combination of ordered mesoporous molecular sieves and process intensification for the synthesis of 1,4-DHP derivatives is still a research field in development. Therefore, promote greener methodologies in the synthesis of 1,4-DHPs that can be extended to any organic synthesis in fine chemical production is an important goal yet to be achieved.Publicación Ammonium acetate as a novel buffer for highly selective robust urinary HPLC-ICP-MS arsenic speciation methodology(Elsevier, 2021-01-01) Rodríguez, P. F.; López Colón, José Luis; Mendoza, J. L. de; Martín Aranda, Rosa MaríaAmmonium acetate is employed in order to develop a novel HPLC-ICP-MS arsenic speciation methodology applicable to six arsenic species, i.e, AC, AB, AsIII, AsV, DMA and MMA. The most predominant species in the toxicological field are covered in a 30-min chromatogram with reproducible and repeatability peak area ratio. Moreover, typical problems from traditional methods are sorted out by using a robust, high-selective and 75ArCl+ interference-free methodology. Chromatographic and detector optimization ensures low LOQs for each species with acceptable precision and accuracy values obtained using four urinary arsenic speciation PTS enabling to be useful for sub ng mL−1 arsenic exposure assessments.