Persona:
López Tolsa Gómez, Gabriela Eugenia

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López Tolsa Gómez
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Gabriela Eugenia
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2021 - 20253
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Autor: Pellón Suárez de Puga, Ricardo × Fecha de finalización: 2025 ×

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Mostrando 1 - 3 de 3
  • Miniatura
    Publicación
    Environmental enrichment accelerates the acquisition of schedule-induced drinking in rats
    (Elsevier, 2023-09-15) Fuentes Verdugo, Esmeralda; López Tolsa Gómez, Gabriela Eugenia; García Pascual, Raquel; Pellón Suárez de Puga, Ricardo
    Environmental enrichment (EE) provides an improvement in the housing conditions of experimental animals, such as laboratory rats, with greater physical and social stimulation through toys and company in the home cages. Its use is known to influence performance of experimental protocols, but these effects have not been well determined in the schedule-induced drinking (SID) procedure. The main goal of this study was to investigate the effects of EE on the acquisition of SID in 24 12-week-old male Wistar rats, divided into two groups, a group with EE housed with toys and companions, and a group without enrichment in individual housing conditions without toys (social isolation and no environmental enrichment, INEE). A total of 25 sessions, under a fixed time 30 s food reinforcement schedule and with access to water in the experimental chambers were carried out. Sessions lasted 30 min. The results showed that the EE group developed faster the excessive drinking pattern of SID, and drank to higher levels, than the INEE group. The greater development of SID in the EE group contradicts the view of schedule-induced behavior as linked to stress reduction and better suits with the conception of induction related to positive reinforcement.
  • Miniatura
    Publicación
    Temporal distribution of schedule-induced behavior depends on the essential value of the reinforcer
    (Wiley, 2025) Martínez Herrada, Antonio; Pellón Suárez de Puga, Ricardo; López Tolsa Gómez, Gabriela Eugenia
    The development of schedule-induced drinking depends on different variables affecting the food delivered at the end of the interfood interval. There are mixed results concerning the effects of varying magnitude and/or preference of different reinforcers in the development of schedule-induced drinking, with some studies showing higher levels and other studies showing lower levels of drinking. The purpose of this study was to observe how differences in preference for a flavor of equally nutritious food pellets influence the development and maintenance of schedule-induced drinking. Using the operant demand framework, four flavors of food pellets were compared to form two groups: one in which subjects would receive their most preferred flavor and another in which subjects would receive their least preferred flavor. In general, licking rates were lower and magazine-entering rates were higher when the preferred flavor was delivered regardless of the fixed-time schedule used. It is suggested that the value of the reinforcer has a larger influence on the immediately preceding behaviors, which will determine the distribution of competing responses in the interreinforcement intervals. These results are relevant to developing public policies that manipulate the taste of healthy food to increase its consumption.
  • Miniatura
    Publicación
    Chronic ∆-9-Tetrahydrocannabinol administration delays acquisition of schedule-induced drinking in rats and retains long-lasting effects
    (Springer, 2021-08-26) Fuentes Verdugo, Esmeralda; López Tolsa Gómez, Gabriela Eugenia; Pellón Suárez de Puga, Ricardo; Miguens Vázquez, Miguel
    Rationale: Schedule-induced drinking (SID) is a behavioural phenomenon characterized by an excessive and repetitive drinking pattern with a distinctive temporal distribution that has been proposed as a robust and replicable animal model of compulsivity. Despite cannabis currently being the most widely consumed illicit drug, with growing interest in its clinical applications, little is known about the effects of ∆-9-Tetrahydrocannabinol (THC) on SID. Objectives: The effects of chronic and acute THC administration on SID acquisition, maintenance and extinction were studied, as were the effects of such administrations on the distinctive temporal distribution pattern of SID. Methods: THC (5 mg/kg i.p.), or the corresponding vehicle, was administered to adult Wistar rats for 14 days in a row. Subsequently, THC effects on SID acquisition were tested during 21 sessions using a 1h fixed-time 60-s food delivery schedule. Acute effects of THC were also evaluated after SID development. Finally, two extinction sessions were conducted to assess behavioural persistence. Results: The results showed that previous chronic THC treatment delayed SID acquisition and altered the distinctive behavioural temporal distribution pattern during sessions. Moreover, acute THC administration after SID development decreased SID performance in animals chronically pre-treated with the drug. No great persistence effects were observed during extinction in animals pre-treated with THC. Conclusions: These results suggest that chronic THC affects SID development, confirming that it can disrupt learning, possibly causing alterations in time estimation, and also leads to animals being sensitized when they are re-exposed to the drug after long periods without drug exposure.