This chapter is focused on analysing the processes and elements that have shaped the particular neopatrimonial and authoritarian nature of the Uzbek state, from its origins and early consolidation under Karimov to the transformations during Mirziyoyev’s presidency. These factors have predominantly developed in the domestic sphere, due to the high degree of autonomy from outside influence of Uzbek authorities and elite networks, compared to other Central Asian cases, such as Kyrgyzstan, Tajikistan or Turkmenistan. This tendency may vary in the future, if the development strategy of “openness” started by President Mirziyoyev is finally consolidated.