Persona: Pellón Suárez de Puga, Ricardo
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0000-0002-4099-7621
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Pellón Suárez de Puga
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Ricardo
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Publicación The Effect of Methylphenidate on the Microstructure of Schedule-Induced Polydipsia in an animal model of ADHD(Elsevier, 2017-08-30) Daniels, Carter W.; Sanabria, Federico; Ibias Martín, Javier; Miguens Vázquez, Miguel; Pellón Suárez de Puga, RicardoSchedule-induced polydipsia (SIP) was established in spontaneously hypertensive rats (SHR), Wistar Kyoto rats (WKY), and Wistar rats, using a multiple fixed-time (FT) schedule of food delivery, with 30- and 90-s components. Thereafter, animals were exposed to methylphenidate (MPH; 2.5 mg/kg/d) for six consecutive SIP sessions. A test to assess possible sensitization effects was also conducted four days after termination of the drug treatment. At baseline, FT 90-s produced longer and more frequent drinking episodes in SHR than in WKY. An analysis of the distribution of inter-lick intervals revealed that drinking was organized in bouts, which were shorter in SHR than in WKY. Across strains and schedules, MPH shifted drinking episodes towards the beginning of inter-food intervals, which may reflect a stimulant effect on SIP. MPH transiently reduced the frequency of drinking episodes in WKY in FT 30-s, and more permanently reduced the frequency of licking bouts in Wistar rats. MPH also increased the length of licking bouts in Wistar rats. Overall, SHR displayed a hyperactive-like pattern of drinking (frequent but short bouts), which 2.5 mg/kg MPH appears to reduce in WKY and Wistar but not in SHR rats. It appears that therapeutic effects of MPH on hyperactive-like SIP require higher doses in SHR relative to control strains.Publicación Delay Gradients for Spout-Licking and Magazine-Entering Induced by a Periodic Food Schedule(Springer Nature, 2018-03-26) Killeen, Peter R.; Pellón Suárez de Puga, Ricardo; Ibias Martín, JavierThe present experiments studied impulsivity by manipulating the delay between target responses and presentation of a reinforcer. Food-deprived SHR, WKY, and Wistar rats were exposed to a fixed-time 30-s schedule of food pellet presentation until they developed stable patterns of water spout-licking and magazine-entering. In successive phases of the study, a resetting delay contingency postponed food delivery if target responses (licks or entries) occurred within the last 1, 2, 5, 10, 20, 25, or 28 s of the inter-food interval. Response-food delays were applied independently for the two behaviors during separate experimental phases, and order of presentation and the behavior that was punished first were counterbalanced. Licking was induced in the order of Wistar > SHR > WKY, and magazine entries were in the order of SHR > WKY > Wistar. Magazine entries showed steeper delay gradients than licking in SHR and Wistar rats but were of similar great inclination in the WKY rats. The different responses were differentially sensitive to delays. This suggests a different ordering of them in the interval between reinforcers. It also has implications for attempts to change impulsive behavior, both in terms of the nature of the response and its removal from reinforcing consequences.Publicación Exercise, diet, and the reinforcing value of food in an animal model of anorexia nervosa(SAGE, 2019) Paz Regidor, Ana María de; Vidal García, Pedro; Pellón Suárez de Puga, Ricardo; SAGEActivity-based anorexia (ABA) develops when laboratory rats are subjected to a single meal per day and have access to an activity wheel for the remaining time. Here, we studied the contribution of exercise and diet to the reinforcing value of food during ABA development. Three groups of eight adult male Wistar rats were used: an ABA group with 21.5 hr (then 22 hr) of wheel access and 1 hr (then 30 min) of food access, a control group with the same time exposure to food but without exercise, and a yoked group to the ABA in terms of weight loss. Rats were daily tested on a progressiveratio schedule to measure their motivation for food. ABA rats gradually reduced their body weight more than the food control group. Animals steadily increased their breaking points in parallel to losses in body weight, but no significant differences were found between groups. Adult rats can develop ABA, but their loss in weight neither resulted in a decrease of food intake nor in the motivation to obtain it.