Persona:
González Crevillén, Agustín

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ORCID
0000-0002-4470-6502
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Proyectos de investigación
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González Crevillén
Nombre de pila
Agustín
Nombre

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2021 - 20222
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Autor: Escarpa, Alberto ×

Resultados de la búsqueda

Mostrando 1 - 2 de 2
  • Miniatura
    Publicación
    Effect of nanocellulose polymorphism on electrochemical analytical performance in hybrid nanocomposites with non‑oxidized single‑walled carbon nanotubes
    (Springer, 2022-06-14) Dortez, Silvia; Sierra, Tania; Álvarez‑Sánchez, Miguel Á.; González‑Domínguez, José M.; Benito, Ana M.; Maser, Wolfgang K.; González Crevillén, Agustín; Escarpa, Alberto
    Two cellulose nanocrystals/single-walled carbon nanotube (CNC/SW) hybrids, using two cellulose polymorphs, were evaluated as electrochemical transducers: CNC type I (CNC-I/SW) and CNC type II (CNC-II/SW). They were synthesized and fully characterized, and their analytical performance as electrochemical sensors was carefully studied. In comparison with SWCNT-based and screen-printed carbon electrodes, CNC/SW sensors showed superior electroanalytical performance in terms of sensitivity and selectivity, not only in the detection of small metabolites (uric acid, dopamine, and tyrosine) but also in the detection of complex glycoproteins (alpha-1-acid glycoprotein (AGP)). More importantly, CNC-II/SW exhibited 20 times higher sensitivity than CNC-I/SW for AGP determination, yielding a LOD of 7 mg L −1 .These results demonstrate the critical role played by nanocellulose polymorphism in the electrochemical performance of CNC/SW hybrid materials, opening new directions in the electrochemical sensing of these complex molecules. In general, these high-active-surface hybrids smartly exploited the preserved non-oxidized SW conductivity with the high aqueous dispersibility of the CNC, avoiding the use of organic solvents or the incorporation of toxic surfactants during their processing, making the CNC/SW hybrids promising nanomaterials for electrochemical detection following greener approaches.
  • Miniatura
    Publicación
    Pump-Free Microfluidic Device for the Electrochemical Detection of α1-Acid Glycoprotein
    (American Chemical Society Publications, 2021-07-05) Tania, Sierra; Jang, Ilhoon; Noviana, Eka; González Crevillén, Agustín; Escarpa, Alberto; S. Henry, Charles
    α1-Acid glycoprotein (AGP) is a glycoprotein present in serum, which is associated with the modulation of the immune system in response to stress or injuries, and a biomarker for inflammatory diseases and cancers. Here, we propose a pump-free microfluidic device for the electrochemical determination of AGP. The microfluidic device utilizes capillary-driven flow and a passive mixing system to label the AGP with the Os (VI) complex (an electrochemical tag) inside the main channel, before delivering the products to the electrode surface. Furthermore, thanks to the resulting geometry, all the analytical steps can be carried out inside the device: labeling, washing, and detection by adsorptive transfer stripping square wave voltammetry. The microfluidic device exhibited a linear range from 500 to 2000 mg L–1 (R2 = 0.990) and adequate limit of detection (LOD = 231 mg L–1). Commercial serum samples were analyzed to demonstrate the success of the method, yielding recoveries around 83%. Due to its simplicity, low sample consumption, low cost, short analysis time, disposability, and portability, the proposed method can serve as a point-of-care/need testing device for AGP.