Persona:
Vidal García, Pedro

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Vidal García
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Pedro
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2019 - 201912020 - 20222
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Autor: Paz Regidor, Ana María de ×

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Mostrando 1 - 3 de 3
  • Miniatura
    Publicación
    Exercise, diet, and the reinforcing value of food in an animal model of anorexia nervosa
    (SAGE, 2019) Paz Regidor, Ana María de; Vidal García, Pedro; Pellón Suárez de Puga, Ricardo; SAGE
    Activity-based anorexia (ABA) develops when laboratory rats are subjected to a single meal per day and have access to an activity wheel for the remaining time. Here, we studied the contribution of exercise and diet to the reinforcing value of food during ABA development. Three groups of eight adult male Wistar rats were used: an ABA group with 21.5 hr (then 22 hr) of wheel access and 1 hr (then 30 min) of food access, a control group with the same time exposure to food but without exercise, and a yoked group to the ABA in terms of weight loss. Rats were daily tested on a progressiveratio schedule to measure their motivation for food. ABA rats gradually reduced their body weight more than the food control group. Animals steadily increased their breaking points in parallel to losses in body weight, but no significant differences were found between groups. Adult rats can develop ABA, but their loss in weight neither resulted in a decrease of food intake nor in the motivation to obtain it.
  • Miniatura
    Publicación
    Activity-Based Anorexia
    (Springer, 2020) Paz Regidor, Ana María de; Vidal García, Pedro; Pellón Suárez de Puga, Ricardo; Springer
  • Miniatura
    Publicación
    Activity-based anorexia alters hypothalamic POMC and orexin populations in male rats
    (Elsevier, 2022-08-11) Pinos, Helena; Sánchez Serrano, Ricardo; Carrillo Urbano, Beatriz; Fernández García, José Manuel; García Úbeda, Rocío; Paz Regidor, Ana María de; López Tolsa Gómez, Gabriela Eugenia; Vidal García, Pedro; Gutiérrez Ferre, Valeria Edith; Pellón Suárez de Puga, Ricardo; Collado Guirao, Paloma
    The objective of this study was to investigate the orexin and POMC populations in the hypothalamic nuclei of male Wistar rats after the activity-based anorexia (ABA) procedure. Four groups were established based on food restriction and activity: activity (A), ABA, diet (D) and control (C). The ABA protocol consisted of free access to a running wheel for a period of 22 h and access to food for 1 h. When the animals in the ABA group reached the ABA criterion, were sacrificed, and their brains were collected and serially sectioned. The free-floating sections were processed for orexin and POMC immunostaining. The number of orexin A-ir cells in the perifornical-dorsomedial-hypothalamus continuum (PFD) and lateral hypothalamus (LH) and the number of POMC-ir cells in the arcuate nucleus (Arc) were estimated. Data on food intake, body weight and wheel turns were also analyzed. The ABA procedure caused a significant decrease in body weight along with a significant increase in activity. Moreover, at the end of the ABA procedure, the number of POMC-ir cells decreased in the Arc in the A group, and significantly more in the ABA group, and the number of orexin A-ir positive cells decreased in the LH in D and ABA groups. The differential decrease in POMC in the ABA group emphasizes the importance of the melanocortin system in the maintenance of ABA, but more research is needed to elucidate the involvement of this peptide in the mechanism that promotes and maintains anorexia nervosa and how increased activity may interact with all these processes.