Examinando por Autor "Fonseca, I.M."

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    Acidic porous carbons involved in the green and selective synthesis of benzodiazepines
    (Elsevier, 2020-11-01) Godino Ojer, Marina; Matos, Ines; Bernardo, M.; Carvalho, R.; G.P. Soares, Olívia Salomé; Durán Valle, C.; Fonseca, I.M.; Pérez Mayoral, María Elena
    Eco-sustainable and recyclable porous carbons are reported as metal-free catalysts for the synthesis of benzodiazepines for the first time. The porous carbons were able to efficiently catalyse the synthesis of benzodiazepine 1 from o-phenylendiamine 2 and acetone 3 under mild conditions. Both acidic functions and the porosity of the catalysts were determinant features. High conversion values were obtained when using HNO3 oxidized carbons. The highest selectivity to benzodiazepine 1 was obtained in the presence of the most microporous catalyst N-N, which is indicative of the great influence of porous properties. Stronger acid sites and high microporosity of the carbon treated with H2SO4 yield benzodiazepine 1 with total selectivity.