Examinando por Autor "Cancelas, Daniel"

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  • Miniatura
    Publicación
    Deformable registration of multimodal retinal images using a weakly supervised deep learning approach
    (Springer, 2023-03-28) Martínez Río, Javier; Carmona, Enrique J.; Cancelas, Daniel; Novo, Jorge; Ortega, Marcos
    There are different retinal vascular imaging modalities widely used in clinical practice to diagnose different retinal pathologies. The joint analysis of these multimodal images is of increasing interest since each of them provides common and complementary visual information. However, if we want to facilitate the comparison of two images, obtained with different techniques and containing the same retinal region of interest, it will be necessary to make a previous registration of both images. Here, we present a weakly supervised deep learning methodology for robust deformable registration of multimodal retinal images, which is applied to implement a method for the registration of fluorescein angiography (FA) and optical coherence tomography angiography (OCTA) images. This methodology is strongly inspired by VoxelMorph, a general unsupervised deep learning framework of the state of the art for deformable registration of unimodal medical images. The method was evaluated in a public dataset with 172 pairs of FA and superficial plexus OCTA images. The degree of alignment of the common information (blood vessels) and preservation of the non-common information (image background) in the transformed image were measured using the Dice coefficient (DC) and zero-normalized cross-correlation (ZNCC), respectively. The average values of the mentioned metrics, including the standard deviations, were DC = 0.72 ± 0.10 and ZNCC = 0.82 ± 0.04. The time required to obtain each pair of registered images was 0.12 s. These results outperform rigid and deformable registration methods with which our method was compared.
  • Miniatura
    Publicación
    Robust multimodal registration of fluorescein angiography and optical coherence tomography angiography images using evolutionary algorithms
    (Elsevier, 2021-07) Martínez Río, Javier; Carmona, Enrique J.; Cancelas, Daniel; Novo, Jorge; Ortega, Marcos
    Optical coherence tomography angiography (OCTA) and fluorescein angiography (FA) are two different vascular imaging modalities widely used in clinical practice to diagnose and grade different relevant retinal pathologies. Although each of them has its advantages and disadvantages, the joint analysis of the images produced by both techniques to analyze a specific area of the retina is of increasing interest, given that they provide common and complementary visual information. However, in order to facilitate this analysis task, a previous registration of the pair of FA and OCTA images is desirable in order to superimpose their common areas and focus the gaze on the regions of interest. Normally, this task is manually carried out by the expert clinician, but it turns out to be tedious and time-consuming. Here, we present a three-stage methodology for robust multimodal registration of FA and superficial plexus OCTA images. The first one is a preprocessing stage devoted to reducing the noise and segmenting the main vessels in both types of images. The second stage uses the vessel information to do an approximate registration based on template matching. Lastly, the third stage uses an evolutionary algorithm based on differential evolution to refine the previous registration and obtain the optimal registration. The method was evaluated in a dataset with 172 pairs of FA and OCTA images, obtaining a success rate of 98.8%. The best mean execution time of the method was less than 5 s per image.