Publicación: Desnutrición y rehabilitación nutricional: efectos sexualmente diferenciales en el locus coeruleus de la rata
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2010-06-01
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Atribución-NoComercial-SinDerivadas 4.0 Internacional
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Universidad Nacional de Educación a Distancia (España). Facultad de Psicología. Departamento de Psicobiología
Resumen
El objetivo del presente trabajo es comprobar cómo la desnutrición pre y postnatal afecta al desarrollo del locus coeruleus (LC) de ratas machos y hembras, una de sus estructuras sexualmente dimorfas. También se quiere conocer si machos y hembras son afectados diferencialmente cuando se les introduce a la alimentación normal habiendo estado previamente desnutridos. Se utilizó una muestra de 36 crías de rata, equilibradas en cuanto a los sexos, de las que 24 fueron sometidas a desnutrición desde la gestación. A partir del destete, se introdujo a la alimentación normal a 12 crías desnutridas (grupo de rehabilitación). El resultado de los análisis post mortem de los cerebros de los sujetos, revela un menor recuento neuronal en la estructura estudiada en las ratas desnutridas de ambos sexos en comparación con el grupo control. En segundo lugar, se aprecian efectos de la rehabilitación nutricional en el macho, pero no en la hembra. En tercer lugar, el LC de las hembras desnutridas es similar al del macho control. Se discuten varias hipótesis para explicar estos efectos, y se señala la necesidad de relacionar estos desarrollos del LC con observaciones comportamentales.
The objective of this study is to explore how malnutrition affects the development of the locus coeruleus (LC) of male and female rats, one of its sexually dimorphic structures. This study also tests the effects of nutritional rehabilitation on the same structure of previously undernourished males and females. A sexually balanced sample of 36 baby rats was used, of which 24 received a calorically restricted diet from gestation. 12 underfed individuals were introduced to normal nutrition from weaning (rehabilitation group). The results of post mortem brain analysis reveal a lower neuronal count in the studied structure on male and female underfed rats in comparison with control ones. Secondly, the effects of food rehabilitation are appreciated in the male, but not in the female. Thirdly, the LC of undernourished females is similar to that of the control males. Various hypotheses for these effects are discussed, and the necessity of relating these developments of the LC with behavioral observations is pointed out.
The objective of this study is to explore how malnutrition affects the development of the locus coeruleus (LC) of male and female rats, one of its sexually dimorphic structures. This study also tests the effects of nutritional rehabilitation on the same structure of previously undernourished males and females. A sexually balanced sample of 36 baby rats was used, of which 24 received a calorically restricted diet from gestation. 12 underfed individuals were introduced to normal nutrition from weaning (rehabilitation group). The results of post mortem brain analysis reveal a lower neuronal count in the studied structure on male and female underfed rats in comparison with control ones. Secondly, the effects of food rehabilitation are appreciated in the male, but not in the female. Thirdly, the LC of undernourished females is similar to that of the control males. Various hypotheses for these effects are discussed, and the necessity of relating these developments of the LC with behavioral observations is pointed out.
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Palabras clave
desnutrición, rehabilitación nutricional, dimorfismo sexual, desarrollo sistema nervioso, locus coeruleus, malnutrition, nutritional rehabilitation, sexual dimorphism, nervous system development
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Facultad de Psicología
Departamento
Psicobiología