Pereda Pérez, InmaculadaValencia Jiménez, AzucenaBaliyan, ShishirNúñez, ÁngelSanz García, AncorRodríguez Fernández, RaquelEsteban, José AntonioVenero Núñez, CésarZamora Crespo, BertaElsevier2025-01-242025-01-242019-03-29Inmaculada Pereda-Pérez, Azucena Valencia, Shishir Baliyan, Ángel Núñez, Ancor Sanz-García, Berta Zamora, Raquel Rodríguez-Fernández, José Antonio Esteban, César Venero, "Systemic administration of a fibroblast growth factor receptor 1 agonist rescues the cognitive deficit in aged socially isolated rats",Neurobiology of Aging,Volume 78,2019,Pages 155-165,https://doi.org/10.1016/j.neurobiolaging.2019.02.011.ISSN 0197-4580https://doi.org/10.1016/j.neurobiolaging.2019.02.011https://hdl.handle.net/20.500.14468/25505The registered version of this article, first published in “Neurobiology of Aging,Volume 78,2019,Pages 155-165", is available online at the publisher's website: Elsevier, https://doi.org/10.1016/j.neurobiolaging.2019.02.011Social isolation predominantly occurs in elderly people and it is strongly associated with cognitive decline. However, the mechanisms that produce isolation-related cognitive dysfunction during aging remain unclear. Here, we evaluated the cognitive, electrophysiological, and morphological effects of short- (4 weeks) and long-term (12 weeks) social isolation in aged male Wistar rats. Long-term but not short-term social isolation increased the plasma corticosterone levels and impaired spatial memory in the Morris water maze. Moreover, isolated animals displayed dampened hippocampal long-term potentiation in vivo, both in the dentate gyrus (DG) and CA1, as well as a specific reduction in the volume of the stratum oriens and spine density in CA1. Interestingly, social isolation induced a transient increase in hippocampal basic fibroblast growth factor (FGF2), whereas fibroblast growth factor receptor 1 (FGFR1) levels only increased after long-term isolation. Importantly, subchronic systemic administration of FGL, a synthetic peptide that activates FGFR1, rescued spatial memory in long-term isolated rats. These findings provide new insights into the neurobiological mechanisms underlying the detrimental effects on memory of chronic social isolation in the aged.eninfo:eu-repo/semantics/openAccess32 Ciencias Médicas ::3206 Ciencias de la NutriciónartículoCognitionCorticosteroneStressFGFHippocampusLTPCogniciónCorticosteronaEstrésFGFHipocampoPLT