Cabildo Miranda, Mª del PilarCornago, María del PilarSanz, D.Claramunt, R. M.Alkorta, IbonElguero, J.Garcia, J. A.Acuña Castroviejo, DaríoNieto Gómez, Carla IsabelLópez Peláez, Antonio2024-05-202024-05-202015-11-141872-801410.1016/j.molstruc.2015.07.055https://hdl.handle.net/20.500.14468/12778Six new 3(5)-trifluoromethyl-5(3)-substituted-styryl-1H-pyrazoles have been synthesized and their tautomerism studied in solution and in the solid state. The determination of their structures has been based on multinuclear NMR spectroscopy together with GIAO/B3LYP/6–311++G(d,p) theoretical calculations of eight structures for each pyrazole (two tautomers and four conformations). Five out of the six compounds present inhibition percentages of the iNOS isoform higher than 50%. With regard to the nNOS inhibitory activity, only two of the studied compounds show an inhibition of about 50%. Finally, concerning the eNOS, there is a compound presenting a low percentage of inhibition (40.2%) attaining in the other cases 50%.enAtribución-NoComercial-SinDerivadas 4.0 Internacionalinfo:eu-repo/semantics/openAccessartículoFluorinated pyrazolesSynthesis1H, 13C, 19F, 15N NMRGIAO calculationsTautomerismNOS inhibition