Fernández Felipe, J.Merino, B.Sanz Martos, Ana BelénPlaza, A.Contreras, A.Naranjo, V.Morales, LChowen, J. A.Cano, V.Ruiz Gayo, M.Olmo Izquierdo, Nuria Del2024-10-142024-10-142021-10-05Fernández-Felipe, Merino, Sanz-Martos, Plaza, Contreras, Naranjo, Morales, Chowen, Cano, Ruiz-Gayo, & Del Olmo. (2021). Saturated and unsaturated fat diets impair hippocampal glutamatergic transmission in adolescent mice. Psychoneuroendocrinology, 133. https://doi.org/10.1016/J.PSYNEUEN.2021.1054291873-3360https://doi.org/10.1016/j.psyneuen.2021.105429https://hdl.handle.net/20.500.14468/24051The registered version of this article, first published in Psychoneuroendocrinology, is available online at the publisher's website: Elsevier, https://doi.org/10.1016/j.psyneuen.2021.105429La versión registrada de este artículo, publicado por primera vez en Psychoneuroendocrinology, está disponible en línea en el sitio web del editor: Elsevier, https://doi.org/10.1016/j.psyneuen.2021.105429Consumption of high-fat diets (HFD) has been associated with neuronal plasticity deficits and cognitive disorders linked to the alteration of glutamatergic disorders in the hippocampus. As young individuals are especially vulnerable to the effects of nutrients and xenobiotics on cognition, we studied the effect of chronic consumption of saturated (SOLF) and unsaturated oil-enriched foods (UOLF) on: i) spatial memory; ii) hippocampal synaptic transmission and plasticity; and iii) gene expression of glutamatergic receptors and hormone receptors in the hippocampus of adolescent and adult mice. Our results show that both SOLF and UOLF impair spatial short-term memory. Accordingly, hippocampal synaptic plasticity mechanisms underlying memory, and gene expression of NMDA receptor subunits are modulated by both diets. On the other hand, PPARγ gene expression is specifically down-regulated in adolescent SOLF individuals and up-regulated in adult UOLF mice.eninfo:eu-repo/semantics/openAccess61 Psicología24 Ciencias de la VidaartículoSOLFUOLFLTPLTDsynaptic plasticitymemory