Fuentes Verdugo, EsmeraldaPellón Suárez de Puga, RicardoMiguens Vázquez, Miguel2025-02-122025-02-122024-02-28Fuentes-Verdugo, E., Pellón, R. & Miguéns, M. Repeated Δ-9-Tetrahydrocannabinol administration dose dependently increases stablished schedule-induced drinking. Psychopharmacology 241, 1277–1286 (2024). https://doi.org/10.1007/s00213-024-06563-30033-3158; e-ISSN : 1432-2072https://doi.org/10.1007/s00213-024-06563-3https://hdl.handle.net/20.500.14468/25902Esta es la versión aceptada del artículo. La versión registrada fue publicada por primera vez en Psychopharmacology 241, 1277–1286 (2024), está disponible en línea en el sitio web del editor: https://doi.org/10.1007/s00213-024-06563-3. This is the accepted version of the article. The recorded version was first published in Psychopharmacology 241, 1277–1286 (2024), is available online at the publisher's website: https://doi.org/10.1007/s00213-024-06563-3.Rationale: Schedule-induced drinking (SID) reproduces an excessive and repetitive behavioural pattern that has led to propose this procedure as an animal model to study compulsive behaviours. Although it is known that cannabis can cause several adverse effects, in recent years there has been great interest in the medical application of cannabis derivatives for obsessive-compulsive related disorders. Objectives: The present study investigated the effects of repeated THC administration on rates of previously acquired SID, as well as the possible alteration of its temporal distribution along inter-food intervals. Methods: Male Wistar rats acquired SID under a 30 min fixed-time 30-sec food delivery schedule (from 30 to 43 sessions to reach a stable level). Thereafter, 5 or 10 mg/kg daily i.p. injections of THC or vehicle were repeatedly administered for 7 days to evaluate the effects on SID. Results: Repeated THC administration at a dose of 5 mg/kg resulted in an increase on licking. Surprisingly, no effects on SID were observed with the 10 mg/kg dose. However, magazine entries were reduced with both THC doses. THC also modified the temporal distributions of licking and magazine entries during inter-food intervals. Conclusions: The present results show that repeated THC administration may (i) increase induced licking at moderate doses, (ii) reduce magazine entries, and (iii) affect the temporal pattern of SID. These findings suggest that THC does not appear to be beneficial to reduce compulsive behaviour in this animal model, while another collateral effect of THC —such as a greater habitual-like behaviour— needs to be considered.eninfo:eu-repo/semantics/embargoedAccess61 PsicologíaartículoTHCcannabinoidsschedule-induced behaviourtime estimationhabit