Borrego Ruiz, Alejandro2025-02-272025-02-272024Borrego-Ruiz A, Borrego JJ. Fecal Microbiota Transplantation as a Tool for Therapeutic Modulation of Neurological and Mental Disorders. SciBase Neurol. 2024; 2(2): 10182691-7785https://doi.org/10.52768/neurology/1018https://hdl.handle.net/20.500.14468/25986The registered version of this article, first published in “SciBase Neurology 2024; 2(2)", is available online at the publisher's website: SciBase Journals, https://doi.org/10.52768/neurology/1018 La versión registrada de este artículo, publicado por primera vez en “SciBase Neurollogy 2024; 2(2)", está disponible en línea en el sitio web del editor: SciBase Journals, https://doi.org/10.52768/neurology/1018Neurological, psychiatric, and psychological disorders are highly prevalent in the world population, but available pharmacological treatments cause numerous side effects, and also there is an elevated rate of treatment-resistant patients. Dysbiosis of the gut microbiome is implicated in several neurological and mental disorders and, consequently, restoring the imbalance of the gut microbiome can improve the symptoms associated with these conditions. One method of achieving the gut homeostasis is through fecal microbiota transplantation. This approach has been successfully applied in the treatment of microbial pathogens, such as Clostridioides difficile, and as a therapeutic tool in various gastrointestinal diseases. However, its application for the treatment of neuropsychiatric and psychological disorders has been largely unexplored. This review aims to present a summary of studies that have used fecal microbiota transplantation in order to treat neurological and mental disorders; therefore, the mechanisms underlying this particular technique are reviewed, and its influence on the recipient intestinal microbiome is also analyzed.eninfo:eu-repo/semantics/openAccess61 Psicologíaartículofecal microbiota transplantationgut microbiomeneurological disordersmental disorderstreatments