Atribución 4.0 InternacionalDel Pino Castillo, MariaRivero, PabloTaylor, AmyGabriel, Rafael S.2024-09-122024-09-122024Maria Del Pino, Pablo Rivero, Amy Taylor, Rafael Gabriel, Impact of depression and cardiovascular risk factors on cognitive impairment in patients with atrial fibrillation: A Systematic review and meta-analysis, Archives of Gerontology and Geriatrics, Volume 128, 2025, 105601, ISSN 0167-4943, https://doi.org/10.1016/j.archger.2024.1056010167-4943https://doi.org/10.1016/j.archger.2024.105601https://hdl.handle.net/20.500.14468/23725This is the journal pre-proof of an article published by Elsevier in "Archives of Gerontology and Geriatrics" on August 2024, available online: https://doi.org/10.1016/j.archger.2024.105601 Este es el manuscrito aceptado de un artículo publicado por Elsevier en "Archives of Gerontology and Geriatrics" en Agodto 2024, disponible en línea: https://doi.org/10.1016/j.archger.2024.105601BACKGROUND: Atrial fibrillation (AF) is a common cardiac arrhythmia associated with significant cardiovascular morbidity and mortality, as well as cognitive impairment (CI). The interplay between AF and CI is complex, involving various pathophysiological changes and numerous risk factors. Among them, depression has emerged as a significant contributor to both AF and CI, further complicating the relationship between these conditions. OBJECTIVES: This systematic review and meta-analysis aimed to investigate the influence of depression on the development of cognitive impairment in AF patients and assess the predictive value of the CHA2DS2-VASc score for CI risk. METHOS: We searched PubMed, Scopus, and Web of Science for relevant studies without language or date restrictions. Ten studies, comprising 1,605,577 participants, were included. A random-effects model was used for meta-analysis, and heterogeneity was assessed using I2 statistics. Funnel plots and Egger’s test evaluated publication bias. RESULTS: Depression significantly increased the risk of CI in AF patients (OR: 2.23, 95% CI: 1.54-3.21, p<0.01; I2=99%). This association persisted in studies excluding baseline CI (OR: 1.95, 95% CI: 1.33-2.85, p<0.01; I2=88%). Subgroup analysis confirmed these results for both prospective (OR: 1.78, 95% CI: 0.92-3.44, p=0.02; I2=65%) and retrospective studies (OR: 2.63, 95% CI: 1.75-3.93, p<0.01; I2=100%). Analysis of CHA2DS2-VASc risk factors showed associations with CI, particularly cerebrovascular disease (OR: 1.86, 95% CI: 1.61-2.16). CONCLUSIONS: Our findings support the association between depression and cognitive impairment in AF patients, demonstrating the importance of addressing mental health in cardiovascular care. Future research is necessary for a comprehensive understanding of this association.eninfo:eu-repo/semantics/openAccess32 Ciencias MédicasartículoAtrial fibrillationRisk factorsDementiaCognitive impairmentCognitive decline