Borrego Ruiz, AlejandroBorrego, Juan J.Borrego Ruiz, Alejandro2025-06-112025-06-112024-09-19Borrego-Ruiz, A., & Borrego, J.J. (2024). Functional neurological disorder and gut microbiome: Casual or causal relationship?. Journal of Clinical and Basic Psychosomatics, 2(4), 4160. https://doi.org/10.36922/jcbp.41602972-4414https://doi.org/10.36922/jcbp.4160https://hdl.handle.net/20.500.14468/26883The registered version of this article, first published in “Journal of Clinical and Basic Psychosomatics, 2, 2024", is available online at the publisher's website: AccScience Publishing, https://doi.org/10.36922/jcbp.4160 La versión registrada de este artículo, publicado por primera vez en “Journal of Clinical and Basic Psychosomatics, 2, 2024", está disponible en línea en el sitio web del editor: AccScience Publishing, https://doi.org/10.36922/jcbp.4160Functional neurological disorder (FND), or conversion disorder, is a psychosomatic condition that affects the voluntary motor and/or sensory functions of the patient. Its origin is not yet fully understood, but the main risk factors related to this disorder include exposure to recent psychological stressors and previous experience of aversive episodes during childhood, such as abuse, family dysfunction, and neglect. The symptoms of FND result from complex interactions involving the central nervous system and also the endocrine and immune systems. In this work, we hypothesized the relationship between the gut microbiome and the pathophysiology of FND because both share several common features, such as the effects of neurotransmitters, the hippocampal expression of brain-derived neurotrophic factor, and the inflammatory responses. Based on these common aspects, we suggested that stress, gut microbiome, and inflammation factors induce chronic and systemic inflammation of the brain causing neurological disorders, including FND. More specific studies are warranted to validate the casual or causal relationship between FND and the gut microbiome.eninfo:eu-repo/semantics/openAccess61 Psicologíaartículofunctional neurological disorderconversion disordergut microbiomeneurotransmittersmicrobial metabolitesneuroinflammation