Andreoletti, MattiaTeira Serrano, David2024-05-202024-05-202016-01-01https://hdl.handle.net/20.500.14468/15625Statistical evidence is pervasive in medicine. In this chapter we will focus on the reliability of randomized clinical trials (RCTs) conducted to test the safety and efficacy of medical treatments. RCTs are scientific experiments and, as such, we expect them to be replicable: if we repeat the same experiment time and again, we should obtain the same outcome (Norton 2015). The statistical design of the test should guarantee that the observed outcome is not a random event, but rather a real effect of the treatments administered. However, for more than a decade now we have been discussing a replicability crisis across different experimental disciplines including medicine: the outcomes of trials published in very prestigious journals often disappear when the experiment is repeated –see for instance Lehrer 2010, Begley and Ellis 2012, Horton 2015).capítulo de libroStatistical evidenceRCTsreplicabilityreliabilityfalse findings