Contreras, AnaPolín Alía, EduardoMiguéns, MiguelPérez García, CarmenPérez Fernández, VicenteRuiz Gayo, MarianoMorales, LidiaDel Olmo, Nuria2024-11-082024-11-082019-10-15Contreras A, Polín E, Miguéns M, Pérez-García C, Pérez V, Ruiz-Gayo M, Morales L, Del Olmo N. Intermittent-Excessive and Chronic-Moderate Ethanol Intake during Adolescence Impair Spatial Learning, Memory and Cognitive Flexibility in the Adulthood. Neuroscience. 2019 Oct 15;418:205-217. doi: 10.1016/j.neuroscience.2019.08.0510306-4522 | eISSN 1873-7544https://doi.org/10.1016/j.neuroscience.2019.08.051https://hdl.handle.net/20.500.14468/24310The registered version of this article, first published in “Neuroscience 2019, vol 418", is available online at the publisher's website: Elsevier, https://doi.org/10.1016/j.neuroscience.2019.08.051 La versión registrada de este artículo, publicado por primera vez en “Neuroscience 2019, vol 418", está disponible en línea en el sitio web del editor: Elsevier, https://doi.org/10.1016/j.neuroscience.2019.08.051Intermittent and excessive ethanol consumption over very short periods of time, known as binge drinking, is common in the adolescence, considered a vulnerable period to the effects of alcohol in terms of cognitive performance. One of the brain functions most drastically affected by ethanol in adolescent individuals seems to be spatial learning and memory dependent on the hippocampus. In the current study we have focused on the long-lasting effects on spatial learning and memory of intermittent and excessive alcohol consumption compared to chronic and moderate alcohol exposure during adolescence. Five-week old male Wistar rats consumed ethanol for 24 days following two different self-administration protocols that differed in the intake pattern. Spatial learning and memory were evaluated in the radial arm maze. Hippocampal synaptic plasticity was assessed by measuring field excitatory postsynaptic potentials. Hippocampal expression of AMPA and NMDA receptor subunits as well as levels of phosphorylated Ser9-GSK3β (the inactive form of GSK3β) were also quantified. Our results show that both patterns of ethanol intake during adolescence impair spatial learning, memory and cognitive flexibility in the adulthood in a dosedependent way. Nevertheless, changes in synaptic plasticity, gene expression and levels of inactive GSK3β depended on the pattern of ethanol intake.eninfo:eu-repo/semantics/restrictedAccess61 PsicologíaartículoGSK3βadolescencebinge drinkinghippocampuslong-term depressionmemory