Rodríguez Muñoz, María de la FeMartín Martín, ClaraKovacheva, KatinaOlivares, Maria EugeniaIzquierdo Méndez, NuriaPérez Romero, PilarGarcía Ríos, Estéfani2024-07-042024-07-042024-02-29Rodríguez-Muñoz, M.F., Martín-Martín, C., Kovacheva, K. et al. Hygiene-based measures for the prevention of cytomegalovirus infection in pregnant women: a systematic review. BMC Pregnancy Childbirth 24, 172 (2024). https://doi.org/10.1186/s12884-024-06367-51471-2393https://doi.org/10.1186/s12884-024-06367-5https://hdl.handle.net/20.500.14468/22832The registered version of this article, first published in BMC Pregnancy and Childbirth, is available online at the publisher's website: Springer Nature, https://doi.org/10.1186/s12884-024-06367-5La versión registrada de este artículo, publicado por primera vez en BMC Pregnancy and Childbirth, está disponible en línea en el sitio web del editor: Springer Nature, https://doi.org/10.1186/s12884-024-06367-5Background Human Cytomegalovirus (HCMV) is the most frequent congenital infection worldwide causing important sequelae. However, no vaccine or antiviral treatments are currently available, thus interventions are restricted to behavioral measures. The aim of this systematic review was to assess evidence from available intervention studies using hygiene-based measures to prevent HCMV infection during pregnancy. Methods Studies published from 1972 to 2023 were searched in Medline, PsycInfo, and Clinical Trials (PROSPERO, CRD42022344840) according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Methodological quality was assessed by two authors, using ROBE-2 and MINORS. Results After reviewing 6 selected articles, the outcome analysis suggested that implementation of hygiene-based interventions during pregnancy prevent, to some extent, the acquisition of congenital HCMV. Conclusions However, these conclusions are based on limited and low-quality evidence available from few studies using this type of intervention in clinical practice. Thus, it would be necessary to perform effective and homogeneous intervention studies using hygiene-based measures, evaluated in high-quality randomized controlled trials (RCTs).eninfo:eu-repo/semantics/openAccess61 Psicologíajournal articlesystematic reviewcytomegaloviruspregnancycounsellingseroconversion