011false100true score desc 2gaptrue5mapcontentxmltrue50object_type_i,object_type_i_lookup,coverage_period_mt,geographic_area_mt,geographic_coordinates_mt,author_role_mt,contributor_role_mt,org_id_mt,org_role_mt,supervisor_mt,supervisor_id_mi,supervisor_id_mi_lookup,fields_of_research_mi,fields_of_research_mi_lookup,display_type_i,display_type_i_lookup,seo_code_mi,seo_code_mi_lookup,copyright_i,license_i,license_i_lookup,oa_compliance_t,oa_notes_t,grant_id_t,funding_body_t,description_of_resource_t,software_required_t,project_description_t,keywords_mt,project_name_t,project_id_t,isdatasetof_mt,isdatasetof_mt_lookup,notes_t,date_dt,xsd_display_option_mi,xsd_display_option_mi_lookup,file_downloads_i,created_date_dt,updated_date_dt,research_program_mt,title_t,depositor_i,isderivationof_mt,assigned_user_id_mt,assigned_group_id_mi,assigned_group_id_mi_lookup,isdatacomponentof_mt,isannotationof_mt,author_id_mi,author_id_mi_lookup,alternative_title_mt,pid_t,publisher_t,author_mt,contributor_mt,contributor_id_mi,contributor_id_mi_lookup,refereed_i,series_t,journal_name_t,newspaper_t,conference_name_t,book_title_t,identifier_mt,edition_t,subject_mi,subject_mi_lookup,place_of_publication_t,start_page_t,end_page_t,chapter_number_t,issue_number_t,volume_number_t,conference_dates_t,conference_location_t,patent_number_t,country_of_issue_t,description_t,date_available_dt,language_mt,phonetic_title_t,language_of_title_mt,translated_title_t,phonetic_journal_name_t,translated_journal_name_t,phonetic_book_title_t,translated_book_title_t,phonetic_newspaper_t,file_attachment_name_mt,translated_newspaper_t,phonetic_conference_name_t,translated_conference_name_t,issn_mt,isbn_mt,isi_loc_t,prn_t,output_availability_t,na_explanation_t,sensitivity_explanation_t,file_attachment_content_mt,org_unit_name_t,org_name_t,report_number_t,sequence_i,genre_t,genre_type_t,formatted_title_t,formatted_abstract_t,parent_publication_t,convener_t,ismemberof_mt,ismemberof_mt_lookup,link_mt,link_description_mt,rights_t,views_i,scopus_id_t,thomson_citation_count_i,gs_citation_count_i,gs_cited_by_link_t,scopus_citation_count_i,status_i,status_i_lookup,first_author_in_document_derived_t,first_author_in_fez_derived_t,ands_collection_type_t,start_date_dt,end_date_dt,access_conditions_t,extent_t,contact_details_email_mt,contact_details_physical_mt,loc_subject_heading_mt,depositor_affiliation_i,surrounding_features_mt,condition_mt,style_mt,period_mt,category_mt,subcategory_mt,structural_systems_mt,adt_id_t,subtype_t,language_of_parent_title_t,proceedings_title_t,file_description_mt,herdc_code_i,herdc_code_i_lookup,herdc_status_i,herdc_status_i_lookup,institutional_status_i,institutional_status_i_lookup,herdc_notes_t,follow_up_flags_i,follow_up_flags_i_lookup,follow_up_flags_imu_i,follow_up_flags_imu_i_lookup,scopus_doc_type_t,scopus_doc_type_t_lookup,wok_doc_type_t,wok_doc_type_t_lookup,conference_id_i,total_chapters_t,publisher_id_i,translated_proceedings_title_t,native_script_title_t,roman_script_title_t,native_script_book_title_t,roman_script_book_title_t,native_script_journal_name_t,roman_script_journal_name_t,native_script_conference_name_t,roman_script_conference_name_t,total_pages_t,native_script_proceedings_title_t,roman_script_proceedings_title_t,language_of_book_title_mt,language_of_journal_name_mt,language_of_proceedings_title_mt,doi_t,author_count_t,collection_year_dt,location_mt,building_materials_mt,architectural_features_mt,interior_features_mt,sherpa_colour_t,ain_detail_t,rj_2010_rank_t,rj_2010_title_t,rj_2012_rank_t,rj_2012_title_t,rc_2010_rank_t,rc_2010_title_t,herdc_code_description_t,score,citation_t1true60 (drug addiction AND status_i:(2)) 6display_type_idisplay_type_i_lookup_exactkeywords_mftdate_year_tauthor_id_miauthor_id_mi_lookup_exactauthor_mftjournal_name_t_ftsubject_misubject_mi_lookup_exactgenre_type_t_ftismemberof_mftismemberof_mt_lookup_exactsubtype_t_ftscopus_doc_type_t_ftscopus_doc_type_t_lookup_exact(_authlister_t:(1)) AND (status_i:(2)) 34232015-09-01T00:00:00Z3552016-04-20T21:25:01Z2016-04-20T21:25:01ZAddiction to drugs, evolution and society: a study on the addiction starting from the evolutionary psychologybibliuned:revistaRH-2015-26-7025Este artículo tiene como objetivo analizar los fundamentos evolutivos de la adicción humana a las sustancias psicoactivas. Con este fin, hemos utilizado dos hipótesis dicotómicas recurrentes en la literatura de la psicología evolutiva. La primera es07612<a class="citation_author_name" title="Navegar por nombre de Autor de Moraes, Thiago Perez Bernardes de" href="/fez/list/author/Moraes, Thiago Perez Bernardes de/">Moraes, Thiago Perez Bernardes de</a> y <a class="citation_author_name" title="Navegar por nombre de Autor de Torrecillas, Geraldo Leopoldo Silva de" href="/fez/list/author/Torrecillas, Geraldo Leopoldo Silva de/">Torrecillas, Geraldo Leopoldo Silva de</a> . (<span class="citation_date">2015</span>) <a class="citation_title" title="Click para ver : Addiction to drugs, evolution and society: a study on the addiction starting from the evolutionary psychology" href="/fez/view/bibliuned:revistaRH-2015-26-7025">Addiction to drugs, evolution and society: a study on the addiction starting from the evolutionary psychology</a>. RecordArtículo de revistaPublishedPsicologíaUniversidad Nacional de Educación a Distancia (UNED). Centro Asociado de SevillaMoraes, Thiago Perez Bernardes deTorrecillas, Geraldo Leopoldo Silva de1Revista de Humanidadesbibliuned:revistaRH-2015-26-7025http://e-spacio.uned.es/fez/view/bibliuned:revistaRH-2015-26-702512914426engLa adicción a las drogas, evolución y sociedad: un estudio sobre la adicción a partir de la psicología evolutivaAddiction_to_drugs.pdfpresmd_Addiction_to_drugs.xml1130-5029, EISSN: 2340-8995bibliuned:revistaRH-2015-26bibliuned:Setarticulobibliuned:SetopenaireRevista de Humanidades. Año 2015, n. 26Set de artículoSet de openairehttp://creativecommons.org/licenses/by-nc/4.0Licencia de acceso Creative CommonsMoraesAcceso abierto10.5944/rdh.26.2015.163421.718673334232019-01-01T00:00:00Z52024-02-01T05:40:49Z2024-02-01T05:40:49ZCentral nucleus of the amygdala as a common substrate of the incubation of drug and natural reinforcer seekingbibliuned:DptoPSIBIO-FPSI-Articulos-Mucha-0001Relapse into drug use is a major problem faced by recovering addicts. In humans, an intensification of the desire for the drug induced by environmental cues—incubation of drug craving—has been observed. In rodents, this phenomenon has been modeled by studying drug seeking under extinction after different times of drug withdrawal (or using a natural reinforcer). Although much progress has been made, an integrated approach simultaneously studying different drug classes and natural reward and examining different brain regions is lacking. Lewis rats were used to study the effects of cocaine, heroin, and sucrose seeking incubation on six key brain regions: the nucleus accumbens shell/core, central/basolateral amygdala, and dorsomedial/ventromedial prefrontal cortex. We analyzed PSD95 and gephyrin protein levels, gene expression of glutamatergic, GABAergic and endocannabinoid elements, and amino acid transmitter levels. The relationships between the areas studied were examined by Structural Equation Modelling. Pathways from medial prefrontal cortex and basolateral complex of the amygdala to central nucleus of the amygdala, but not to the nucleus accumbens, were identified as common elements involved in the incubation phenomenon for different substances. These results suggest a key role for the central nucleus of amygdala and its cortical and amygdalar afferences in the incubation phenomenon, and we suggest that by virtue of its regulatory effects on glutamatergic and GABAergic dynamics within amygdalar circuits, the endocannabinoid system might be a potential target to develop medications that are effective in the context of relapse.0192<a class="citation_author_name" title="Navegar por nombre de Autor de Roura‐Martínez, David" href="/fez/list/author/Roura‐Martínez, David/">Roura‐Martínez, David</a>, <a class="citation_author_name" title="Navegar por nombre de Autor de Ucha, Marcos" href="/fez/list/author/Ucha, Marcos/">Ucha, Marcos</a>, <a class="citation_author_name" title="Navegar por nombre de Autor de Orihuel, Javier" href="/fez/list/author/Orihuel, Javier/">Orihuel, Javier</a> y <a class="citation_author_name" title="Navegar por nombre de Autor de et al." href="/fez/list/author/et al./">et al.</a> . (<span class="citation_date">2019</span>) <a class="citation_title" title="Click para ver : Central nucleus of the amygdala as a common substrate of the incubation of drug and natural reinforcer seeking" href="/fez/view/bibliuned:DptoPSIBIO-FPSI-Articulos-Mucha-0001">Central nucleus of the amygdala as a common substrate of the incubation of drug and natural reinforcer seeking</a>. RecordArtículo de revistaPublishedPsicologíaLa versión registrada de este artículo, publicado por primera vez en Addiction Biology, está disponible en línea en el sitio web del editor: WILEY, https://doi.org/10.1111/adb.12706WILEYRoura‐Martínez, DavidUcha, MarcosOrihuel, Javieret al.1Addiction Biologybibliuned:DptoPSIBIO-FPSI-Articulos-Mucha-0001http://e-spacio.uned.es/fez/view/bibliuned:DptoPSIBIO-FPSI-Articulos-Mucha-0001112engUcha_Tortuero_Marcos_CentralNucleus.pdfpresmd_Ucha_Tortuero_Marcos_CentralNucleus.xml1369-1600, 1355-6215bibliuned:DptoPSIBIO-FPSI-Articulosbibliuned:Setarticulobibliuned:SetopenaireDepartamento de Psicobiología (UNED). ArtículosSet de artículoSet de openairehttp://creativecommons.org/licenses/by-nc-nd/4.0Licencia Creative CommonsRoura‐MartínezAcceso abiertohttps://doi.org/10.1111/adb.127061.145823734232020-01-01T00:00:00Z142024-02-01T06:07:41Z2024-02-01T06:09:20ZComparative analysis of the modulation of perineuronal nets in the prefrontal cortex of rats during protracted withdrawal from cocaine, heroin and sucrose self-administrationbibliuned:DptoPSIBIO-FPSI-Articulos-Mucha-0002Relapse into drug use is a significant problem for people recovering from addiction. The ability that conditioned cues have to reinstate and reinvigorate drug-seeking is potentiated over time (incubation of seeking), posing an additional difficulty for maintaining abstinence. While the prefrontal cortex has been involved in the incubation phenomenon and the extracellular matrix, perineuronal nets (PNNs) in particular, may play a vital role in brain plasticity associated to drug relapse, there are no comparative analyses between different drug classes and natural reinforcers. Here, we compare the effects of early (1 day) and protracted (30 days) withdrawal from to cocaine, heroin and sucrose self-administration on the total density and density per intensity range of PNNs of different territories of the prefrontal cortex of male Lewis rats. Our results show that cocaine self-administration increases the density of PNNs in the dorsal prelimbic, infralimbic and ventral orbitofrontal cortices, while protracted withdrawal reversesthis effect in the dorsal prelimbic cortex. Also, heroin self-administration increases the density of PNNs in the infralimbic cortex and ventral orbitofrontal cortices, but this effect is lost after 30 days of withdrawal in the infralimbic cortex. Finally, the self-administration of sucrose-sweetened water or the protracted withdrawal from this powerful reinforcer does not affect any of the PNN parameters analysed. Our results show that two different drugs of abuse (but not a natural reward) with specific pharmacological and physiological actions, differentially modulate PNNs in specific areas of the rodent prefrontal cortex with potential implications for the incubation of seeking phenomenon.0272<a class="citation_author_name" title="Navegar por nombre de Autor de Roura-Martínez, David" href="/fez/list/author/Roura-Martínez, David/">Roura-Martínez, David</a>, <a class="citation_author_name" title="Navegar por nombre de Autor de Díaz-Bejarano, Paula" href="/fez/list/author/Díaz-Bejarano, Paula/">Díaz-Bejarano, Paula</a>, <a class="citation_author_name" title="Navegar por nombre de Autor de Ucha, Marcos" href="/fez/list/author/Ucha, Marcos/">Ucha, Marcos</a> y <a class="citation_author_name" title="Navegar por nombre de Autor de et al." href="/fez/list/author/et al./">et al.</a> . (<span class="citation_date">2020</span>) <a class="citation_title" title="Click para ver : Comparative analysis of the modulation of perineuronal nets in the prefrontal cortex of rats during protracted withdrawal from cocaine, heroin and sucrose self-administration" href="/fez/view/bibliuned:DptoPSIBIO-FPSI-Articulos-Mucha-0002">Comparative analysis of the modulation of perineuronal nets in the prefrontal cortex of rats during protracted withdrawal from cocaine, heroin and sucrose self-administration</a>. RecordArtículo de revistaPublishedPsicologíaLa versión registrada de este artículo, publicado por primera vez en Neuropharmacology, está disponible en línea en el sitio web del editor: Elsevier, https://doi.org/10.1016/j.neuropharm.2020.108290ElsevierRoura-Martínez, DavidDíaz-Bejarano, PaulaUcha, Marcoset al.Neuropharmacologybibliuned:DptoPSIBIO-FPSI-Articulos-Mucha-0002http://e-spacio.uned.es/fez/view/bibliuned:DptoPSIBIO-FPSI-Articulos-Mucha-0002engUcha_Tortuero_Marcos_ComparativeAnalysis.pdfpresmd_Ucha_Tortuero_Marcos_ComparativeAnalysis.xml0028-3908bibliuned:DptoPSIBIO-FPSI-Articulosbibliuned:Setarticulobibliuned:SetopenaireDepartamento de Psicobiología (UNED). ArtículosSet de artículoSet de openairehttp://creativecommons.org/licenses/by-nc-nd/4.0Licencia Creative CommonsRoura-MartínezAcceso abiertohttps://doi.org/10.1016/j.neuropharm.2020.1082900.804611734232021-01-01T00:00:00Z62024-02-01T08:17:10Z2024-02-01T08:17:10ZΔ 9-Tetrahydrocannabinol during adolescence reprograms the nucleus accumbens transcriptome, affecting reward processing, impulsivity, and specific aspects of cocaine addiction-like behavior in a sex-dependent mannerbibliuned:DptoPSIBIO-FPSI-Articulos-Mucha-0007Background: Cannabis exposure during adolescence is associated with emotional and motivational alterations that may entail an enhanced risk of developing psychiatric disorders. In rodent models, exposure to cannabinoids during adolescence leads to increased self-administration of opiates and cocaine, however, the psychological and neural mechanisms and the sex-specificity of this phenomenon are largely unknown. Methods: We exposed male and female adolescent rats to Δ9-tetrahydrocannabinol (THC) and studied at adulthood the effects of such treatment on psychological processes related to reward, such as Pavlovian conditioned approach, Pavlovian to instrumental transfer, habit formation and waiting impulsivity. In the light of these data and given the involvement of the nucleus accumbens in the processes examined, we performed an RNASeq transcriptomic study and assessed cocaine addiction-like behavior. Results: THC exposure increased goal-tracking (in males and females) and enhanced Pavlovian to instrumental transfer (especially in males) but did not affect habit formation. THC-exposed rats exhibited subtle, state-dependent changes in premature responding in the 2-CSRTT task. RNASeq data showed gene expression alterations in a marked sex-specific manner. While no effects were found on the acquisition of cocaine self-administration or punished drug-seeking, rats exposed to THC self-administered more cocaine under a progressive ratio schedule (males), had a higher rebound upon returning to continuous access to the drug (females) and showed reduced drug-seeking after 30 days of withdrawal (females). Conclusions: Adolescent THC affects specific aspects of reward- (and cocaine-) guided behavior and the function of a key brain region mediating these effects, in a remarkable sex-specific manner.0272<a class="citation_author_name" title="Navegar por nombre de Autor de Orihuel, Javier" href="/fez/list/author/Orihuel, Javier/">Orihuel, Javier</a>, <a class="citation_author_name" title="Navegar por nombre de Autor de Capellán, Roberto" href="/fez/list/author/Capellán, Roberto/">Capellán, Roberto</a>, <a class="citation_author_name" title="Navegar por nombre de Autor de Ucha, Marcos" href="/fez/list/author/Ucha, Marcos/">Ucha, Marcos</a> y <a class="citation_author_name" title="Navegar por nombre de Autor de et al." href="/fez/list/author/et al./">et al.</a> . (<span class="citation_date">2021</span>) <a class="citation_title" title="Click para ver : Δ 9-Tetrahydrocannabinol during adolescence reprograms the nucleus accumbens transcriptome, affecting reward processing, impulsivity, and specific aspects of cocaine addiction-like behavior in a sex-dependent manner" href="/fez/view/bibliuned:DptoPSIBIO-FPSI-Articulos-Mucha-0007">Δ 9-Tetrahydrocannabinol during adolescence reprograms the nucleus accumbens transcriptome, affecting reward processing, impulsivity, and specific aspects of cocaine addiction-like behavior in a sex-dependent manner</a>. RecordArtículo de revistaPublishedPsicologíaLa versión registrada de este artículo, publicado por primera vez en Journal of Psychopharmacology, está disponible en línea en el sitio web del editor: Oxford Academic, https://doi.org/10.1093/ijnp/pyab058Oxford AcademicOrihuel, JavierCapellán, RobertoUcha, Marcoset al.1International Journal of Neuropsychopharmacologybibliuned:DptoPSIBIO-FPSI-Articulos-Mucha-0007http://e-spacio.uned.es/fez/view/bibliuned:DptoPSIBIO-FPSI-Articulos-Mucha-00079209331124engUcha_Tortuero_Marcos_TetrahydrocannabinolAdolescence.pdfpresmd_Ucha_Tortuero_Marcos_TetrahydrocannabinolAdolescence.xml1469-5111, 1461-1457bibliuned:DptoPSIBIO-FPSI-Articulosbibliuned:Setarticulobibliuned:SetopenaireDepartamento de Psicobiología (UNED). ArtículosSet de artículoSet de openairehttp://creativecommons.org/licenses/by-nc/4.0Licencia Creative CommonsOrihuelAcceso abiertohttps://doi.org/10.1093/ijnp/pyab0580.771023834232019-01-01T00:00:00Z82024-02-01T07:35:04Z2024-02-01T07:35:04ZMorphine self-administration alters the expression of translational machinery genes in the amygdala of male Lewis ratsbibliuned:DptoPSIBIO-FPSI-Articulos-Mucha-0005Background: Addiction is a chronic disorder with a high risk of relapse. The neural mechanisms mediating addictions require protein synthesis, which could be relevant for the development of more effective treatments. The mTOR signaling pathway regulates protein synthesis processes that have recently been linked to the development of drug addiction. Aims: To assess the effects of morphine self-administration and its subsequent extinction on the expression of several genes that act in this pathway, and on the levels of specific phosphoproteins (Akt, Gsk3α/β, mTOR, PDK1 and p70 S6 kinase) in the amygdala, nucleus accumbens, and the prefrontal cortex. Methods: Male Lewis rats underwent morphine self-administration (1 mg/kg) for 19 days. They subsequently were submitted to extinction training for 15 days. Rats were killed either after self-administration or extinction, their brains extracted, and gene expression or phosphoprotein levels were assessed. Results: We found an increase in Raptor and Eif4ebp2 expression in the amygdala of rats that self-administered morphine, even after extinction. The expression of Insr in the amygdala of control animals decreased over time while the opposite effect was seen in the rats that self-administered morphine. Conclusions: Our results suggest that morphine self-administration affects the gene expression of some elements of the translational machinery in the amygdala.0172<a class="citation_author_name" title="Navegar por nombre de Autor de Ucha, Marcos" href="/fez/list/author/Ucha, Marcos/">Ucha, Marcos</a>, <a class="citation_author_name" title="Navegar por nombre de Autor de Coria, Santiago M." href="/fez/list/author/Coria, Santiago M./">Coria, Santiago M.</a>, <a class="citation_author_name" title="Navegar por nombre de Autor de Núñez, Adrián E." href="/fez/list/author/Núñez, Adrián E./">Núñez, Adrián E.</a> y <a class="citation_author_name" title="Navegar por nombre de Autor de et al." href="/fez/list/author/et al./">et al.</a> . (<span class="citation_date">2019</span>) <a class="citation_title" title="Click para ver : Morphine self-administration alters the expression of translational machinery genes in the amygdala of male Lewis rats" href="/fez/view/bibliuned:DptoPSIBIO-FPSI-Articulos-Mucha-0005">Morphine self-administration alters the expression of translational machinery genes in the amygdala of male Lewis rats</a>. RecordArtículo de revistaPublishedPsicologíaLa versión registrada de este artículo, publicado por primera vez en Journal of Psychopharmacology, está disponible en línea en el sitio web del editor: SAGE Publications, https://doi.org/10.1177/0269881119836206SAGE PublicationsUcha, MarcosCoria, Santiago M.Núñez, Adrián E.et al.1Journal of Psychopharmacologybibliuned:DptoPSIBIO-FPSI-Articulos-Mucha-0005http://e-spacio.uned.es/fez/view/bibliuned:DptoPSIBIO-FPSI-Articulos-Mucha-0005882893733engUcha_Tortuero_Marcos_MorphineAdministration.pdfpresmd_Ucha_Tortuero_Marcos_MorphineAdministration.xml0269-8811, eISSN 1461-7285bibliuned:DptoPSIBIO-FPSI-Articulosbibliuned:Setarticulobibliuned:SetopenaireDepartamento de Psicobiología (UNED). ArtículosSet de artículoSet de openairehttp://creativecommons.org/licenses/by/4.0Licencia Creative CommonsUchaAcceso abiertohttps://doi.org/10.1177/02698811198362060.721525435552442554554