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(cocaine AND status_i:(2)) 6display_type_idisplay_type_i_lookup_exactkeywords_mftdate_year_tauthor_id_miauthor_id_mi_lookup_exactauthor_mftjournal_name_t_ftsubject_misubject_mi_lookup_exactgenre_type_t_ftismemberof_mftismemberof_mt_lookup_exactsubtype_t_ftscopus_doc_type_t_ftscopus_doc_type_t_lookup_exact(_authlister_t:(1)) AND (status_i:(2)) 34232011-04-01T00:00:00Z2162013-05-29T17:21:35Z2015-10-15T02:32:46ZTrastornos de la personalidad en fumadores y personas con dependencia de la cocaína que acuden a tratamiento : un estudio comparativo = Personality disorders in smokers and cocaine dependent subjects who request treatment : a comparative studybibliuned:Psicopat-2011-16-1-1025El objetivo del presente estudio fue evaluar y comparar la presencia de trastornos de la personalidad en fumadores y personas con dependencia de la cocaína al inicio del tratamiento, utilizando para ello el Inventario Clínico Multiaxial de Millon-II (MC06252<a class="citation_author_name" title="Navegar por nombre de Autor de Fernández del Río, Elena" href="/fez/list/author/Fernández del Río, Elena/">Fernández del Río, Elena</a>, <a class="citation_author_name" title="Navegar por nombre de Autor de Cañadas, Guillermo A." href="/fez/list/author/Cañadas, Guillermo A./">Cañadas, Guillermo A.</a>, <a class="citation_author_name" title="Navegar por nombre de Autor de López, Ana" href="/fez/list/author/López, Ana/">López, Ana</a> y <a class="citation_author_name" title="Navegar por nombre de Autor de Becoña Iglesias, Elisardo" href="/fez/list/author/Becoña Iglesias, Elisardo/">Becoña Iglesias, Elisardo</a> . (<span class="citation_date">2011</span>) <a class="citation_title" title="Click para ver : Trastornos de la personalidad en fumadores y personas con dependencia de la cocaína que acuden a tratamiento : un estudio comparativo = Personality disorders in smokers and cocaine dependent subjects who request treatment : a comparative study" href="/fez/view/bibliuned:Psicopat-2011-16-1-1025">Trastornos de la personalidad en fumadores y personas con dependencia de la cocaína que acuden a tratamiento : un estudio comparativo = Personality disorders in smokers and cocaine dependent subjects who request treatment : a comparative study</a>. RecordArtículo de revistaPublisheddependenciacocaínafumartrastornos de personalidadMCMI-IIdependencecocainesmokingpersonality disordersAEPCP ; Universidad Nacional de Educación a Distancia (España)Fernández del Río, ElenaCañadas, Guillermo A.López, AnaBecoña Iglesias, Elisardobibliuned:Psicopat-2011-16-1-1025http://e-spacio.uned.es/fez/view/bibliuned:Psicopat-2011-16-1-1025spaDocumento.pdfbibliuned:Psicopat-2011-16-1bibliuned:Setopenairebibliuned:SetarticuloRevista de psicopatología y psicología clínica. Año 2011, vol. 16, n. 1Set de openaireSet de artículohttp://creativecommons.org/licenses/by-nc-nd/4.0Licencia Creative CommonsFernández del RíoAcceso abierto10.5944/rppc.vol.16.num.1.2011.103520.9592876434232021-01-01T00:00:00Z62024-02-01T08:17:10Z2024-02-01T08:17:10ZΔ 9-Tetrahydrocannabinol during adolescence reprograms the nucleus accumbens transcriptome, affecting reward processing, impulsivity, and specific aspects of cocaine addiction-like behavior in a sex-dependent mannerbibliuned:DptoPSIBIO-FPSI-Articulos-Mucha-0007Background: Cannabis exposure during adolescence is associated with emotional and motivational alterations that may entail an enhanced risk of developing psychiatric disorders. In rodent models, exposure to cannabinoids during adolescence leads to increased self-administration of opiates and cocaine, however, the psychological and neural mechanisms and the sex-specificity of this phenomenon are largely unknown. Methods: We exposed male and female adolescent rats to Δ9-tetrahydrocannabinol (THC) and studied at adulthood the effects of such treatment on psychological processes related to reward, such as Pavlovian conditioned approach, Pavlovian to instrumental transfer, habit formation and waiting impulsivity. In the light of these data and given the involvement of the nucleus accumbens in the processes examined, we performed an RNASeq transcriptomic study and assessed cocaine addiction-like behavior. Results: THC exposure increased goal-tracking (in males and females) and enhanced Pavlovian to instrumental transfer (especially in males) but did not affect habit formation. THC-exposed rats exhibited subtle, state-dependent changes in premature responding in the 2-CSRTT task. RNASeq data showed gene expression alterations in a marked sex-specific manner. While no effects were found on the acquisition of cocaine self-administration or punished drug-seeking, rats exposed to THC self-administered more cocaine under a progressive ratio schedule (males), had a higher rebound upon returning to continuous access to the drug (females) and showed reduced drug-seeking after 30 days of withdrawal (females). Conclusions: Adolescent THC affects specific aspects of reward- (and cocaine-) guided behavior and the function of a key brain region mediating these effects, in a remarkable sex-specific manner.0272<a class="citation_author_name" title="Navegar por nombre de Autor de Orihuel, Javier" href="/fez/list/author/Orihuel, Javier/">Orihuel, Javier</a>, <a class="citation_author_name" title="Navegar por nombre de Autor de Capellán, Roberto" href="/fez/list/author/Capellán, Roberto/">Capellán, Roberto</a>, <a class="citation_author_name" title="Navegar por nombre de Autor de Ucha, Marcos" href="/fez/list/author/Ucha, Marcos/">Ucha, Marcos</a> y <a class="citation_author_name" title="Navegar por nombre de Autor de et al." href="/fez/list/author/et al./">et al.</a> . (<span class="citation_date">2021</span>) <a class="citation_title" title="Click para ver : Δ 9-Tetrahydrocannabinol during adolescence reprograms the nucleus accumbens transcriptome, affecting reward processing, impulsivity, and specific aspects of cocaine addiction-like behavior in a sex-dependent manner" href="/fez/view/bibliuned:DptoPSIBIO-FPSI-Articulos-Mucha-0007">Δ 9-Tetrahydrocannabinol during adolescence reprograms the nucleus accumbens transcriptome, affecting reward processing, impulsivity, and specific aspects of cocaine addiction-like behavior in a sex-dependent manner</a>. RecordArtículo de revistaPublishedPsicologíaLa versión registrada de este artículo, publicado por primera vez en Journal of Psychopharmacology, está disponible en línea en el sitio web del editor: Oxford Academic, https://doi.org/10.1093/ijnp/pyab058Oxford AcademicOrihuel, JavierCapellán, RobertoUcha, Marcoset al.1International Journal of Neuropsychopharmacologybibliuned:DptoPSIBIO-FPSI-Articulos-Mucha-0007http://e-spacio.uned.es/fez/view/bibliuned:DptoPSIBIO-FPSI-Articulos-Mucha-00079209331124engUcha_Tortuero_Marcos_TetrahydrocannabinolAdolescence.pdfpresmd_Ucha_Tortuero_Marcos_TetrahydrocannabinolAdolescence.xml1469-5111, 1461-1457bibliuned:DptoPSIBIO-FPSI-Articulosbibliuned:Setarticulobibliuned:SetopenaireDepartamento de Psicobiología (UNED). ArtículosSet de artículoSet de openairehttp://creativecommons.org/licenses/by-nc/4.0Licencia Creative CommonsOrihuelAcceso abiertohttps://doi.org/10.1093/ijnp/pyab0580.91071834232020-01-01T00:00:00Z142024-02-01T06:07:41Z2024-02-01T06:09:20ZComparative analysis of the modulation of perineuronal nets in the prefrontal cortex of rats during protracted withdrawal from cocaine, heroin and sucrose self-administrationbibliuned:DptoPSIBIO-FPSI-Articulos-Mucha-0002Relapse into drug use is a significant problem for people recovering from addiction. The ability that conditioned cues have to reinstate and reinvigorate drug-seeking is potentiated over time (incubation of seeking), posing an additional difficulty for maintaining abstinence. While the prefrontal cortex has been involved in the incubation phenomenon and the extracellular matrix, perineuronal nets (PNNs) in particular, may play a vital role in brain plasticity associated to drug relapse, there are no comparative analyses between different drug classes and natural reinforcers. Here, we compare the effects of early (1 day) and protracted (30 days) withdrawal from to cocaine, heroin and sucrose self-administration on the total density and density per intensity range of PNNs of different territories of the prefrontal cortex of male Lewis rats. Our results show that cocaine self-administration increases the density of PNNs in the dorsal prelimbic, infralimbic and ventral orbitofrontal cortices, while protracted withdrawal reversesthis effect in the dorsal prelimbic cortex. Also, heroin self-administration increases the density of PNNs in the infralimbic cortex and ventral orbitofrontal cortices, but this effect is lost after 30 days of withdrawal in the infralimbic cortex. Finally, the self-administration of sucrose-sweetened water or the protracted withdrawal from this powerful reinforcer does not affect any of the PNN parameters analysed. Our results show that two different drugs of abuse (but not a natural reward) with specific pharmacological and physiological actions, differentially modulate PNNs in specific areas of the rodent prefrontal cortex with potential implications for the incubation of seeking phenomenon.0272<a class="citation_author_name" title="Navegar por nombre de Autor de Roura-Martínez, David" href="/fez/list/author/Roura-Martínez, David/">Roura-Martínez, David</a>, <a class="citation_author_name" title="Navegar por nombre de Autor de Díaz-Bejarano, Paula" href="/fez/list/author/Díaz-Bejarano, Paula/">Díaz-Bejarano, Paula</a>, <a class="citation_author_name" title="Navegar por nombre de Autor de Ucha, Marcos" href="/fez/list/author/Ucha, Marcos/">Ucha, Marcos</a> y <a class="citation_author_name" title="Navegar por nombre de Autor de et al." href="/fez/list/author/et al./">et al.</a> . (<span class="citation_date">2020</span>) <a class="citation_title" title="Click para ver : Comparative analysis of the modulation of perineuronal nets in the prefrontal cortex of rats during protracted withdrawal from cocaine, heroin and sucrose self-administration" href="/fez/view/bibliuned:DptoPSIBIO-FPSI-Articulos-Mucha-0002">Comparative analysis of the modulation of perineuronal nets in the prefrontal cortex of rats during protracted withdrawal from cocaine, heroin and sucrose self-administration</a>. RecordArtículo de revistaPublishedPsicologíaLa versión registrada de este artículo, publicado por primera vez en Neuropharmacology, está disponible en línea en el sitio web del editor: Elsevier, https://doi.org/10.1016/j.neuropharm.2020.108290ElsevierRoura-Martínez, DavidDíaz-Bejarano, PaulaUcha, Marcoset al.Neuropharmacologybibliuned:DptoPSIBIO-FPSI-Articulos-Mucha-0002http://e-spacio.uned.es/fez/view/bibliuned:DptoPSIBIO-FPSI-Articulos-Mucha-0002engUcha_Tortuero_Marcos_ComparativeAnalysis.pdfpresmd_Ucha_Tortuero_Marcos_ComparativeAnalysis.xml0028-3908bibliuned:DptoPSIBIO-FPSI-Articulosbibliuned:Setarticulobibliuned:SetopenaireDepartamento de Psicobiología (UNED). ArtículosSet de artículoSet de openairehttp://creativecommons.org/licenses/by-nc-nd/4.0Licencia Creative CommonsRoura-MartínezAcceso abiertohttps://doi.org/10.1016/j.neuropharm.2020.1082900.9012794534172019-12-16T00:00:00Z5142020-02-12T22:49:56Z2020-02-12T22:51:01ZA study of the behavioral, anatomical, metabolic and transcriptomic disturbances associated to cocaine addiction-like behaviour in a two-hit animal model of schizophrenia-related symptomstesisuned:ED-Pg-PsiSal-RcapellanLas infecciones prenatales y las experiencias traumáticas en torno a la pubertad son factores de riesgo para el desarrollo de esquizofrenia en la edad adulta, sobre todo en hombres. Además, existe una alta incidencia de trastornos adictivos entre pacientes esquizofrénicos, lo que generalmente empeora el pronóstico de la enfermedad. Por tanto, la caracterización de las perturbaciones subyacentes a esta comorbilidad se vuelve esencial para implementar terapias más eficaces en dichos pacientes. En el presente estudio, empleamos un modelo animal de doble impacto cuyos síntomas se han relacionado con la esquizofrenia para estudiar la presencia de alteraciones conductuales, anatómicas, metabólicas y transcriptómicas asociadas con la adicción a la cocaína. Para ello, inyectamos intraperitonealmente 100 μg/kg/ml de lipopolisacárido (LPS) o solución salina los días gestacionales 15 y 16 a ratas preñadas. Sus descendientes machos fueron sometieron a cinco episodios de estrés o amansamiento en días alternos durante los días postnatales (PND) 28 a 38. Una vez que los animales alcanzaron la edad adulta (PND70), evaluamos la inhibición prepulso (PPI), la memoria de trabajo y la interacción social. En el PND90, se analizaron la impulsividad motora y diferentes aspectos de la autoadministración de cocaína en busca de rasgos cardinales de adicción. Estudios de imagen (MRI, DTI) y espectroscópicos (in/ex vivo H1MRS) por resonancia magnética, de tomografía por emisión de positrones (PET) y de secuenciación masiva de ARN (RNA-Seq) fueron empleados para cuantificar posibles cambios anatómicos, metabólicos y transcriptómicos en el cerebro. Nuestros resultados mostraron que el estrés puberal redujo la autoadministración de cocaína, efecto que se vio revertido en animales expuestos a LPS, que también mostraron una mayor motivación por la droga. Este patrón de consumo resultó ser específico para la cocaína, ya que no se observaron diferencias significativas entre grupos en programas de condicionamiento pavloviano ni instrumental con comida. Además, no se encontraron efectos moduladores de la impulsividad motora. A nivel anatomo-metabólico, la exposición prenatal a LPS redujo el volumen total del cerebro y aumentó la difusividad media del hipocampo en ambos hemisferios. El estrés puberal redujo el volumen del hipocampo derecho y la actividad mesencefálica, al tiempo que aumentó el volumen cortical y dorsoestriatal, así como la actividad hipocampal. Además, la neurotransmisión glutamatérgica estriatal se redujo por la exposición prenatal a LPS y aumentó tras la combinación de estrés puberal probablemente. Estos resultados sugieren una compleja interacción entre los efectos provocados por la activación inmune prenatal y el estrés puberal sobre el neurodesarrollo, y llaman la atención sobre la necesidad de realizar estudios más detallados sobre la comorbilidad entre esquizofrenia y adicción a cocaína.0Doctoral Thesis6692<a class="citation_author_name" title="Navegar por nombre de Autor de Capellán Martín, Roberto" href="/fez/list/author/Capellán Martín, Roberto/">Capellán Martín, Roberto</a>. <b><i><a class="citation_title" title="Click para ver : A study of the behavioral, anatomical, metabolic and transcriptomic disturbances associated to cocaine addiction-like behaviour in a two-hit animal model of schizophrenia-related symptoms" href="/fez/view/tesisuned:ED-Pg-PsiSal-Rcapellan">A study of the behavioral, anatomical, metabolic and transcriptomic disturbances associated to cocaine addiction-like behaviour in a two-hit animal model of schizophrenia-related symptoms</a></i></b> . <span class="citation_date">2019</span>. <span class="citation_publisher">Universidad Nacional de Educación a Distancia (España). Escuela Internacional de Doctorado. Programa de Doctorado en Psicología de la Salud</span>RecordDoctoral ThesisPublishedPsicologíaUniversidad Nacional de Educación a Distancia (España). Escuela Internacional de Doctorado. Programa de Doctorado en Psicología de la SaludCapellán Martín, RobertoHiguera Matas, AlejandroAmbrosio Flores, Emiliotesisuned:ED-Pg-PsiSal-Rcapellanhttp://e-spacio.uned.es/fez/view/tesisuned:ED-Pg-PsiSal-RcapellanengCAPELLAN_MARTIN__Roberto_Tesis.pdfpresmd_CAPELLAN_MARTIN__Roberto_Tesis.xmltesisuned:ED_Pg_PsiSalbibliuned:Setthesisbibliuned:SetopenaireEscuela de Doctorado. Programa de doctorado en Psicología de la Salud (UNED)Set de Tesis Doctorales de la UNEDSet de openairehttps://creativecommons.org/licenses/by-nc-nd/4.0Licencia Creative CommonsCapellán MartínAcceso abierto0.600351434232015-05-01T00:00:00Z4702016-04-26T00:55:39Z2016-04-26T00:55:39ZVariables de interés clínico en el tratamiento cognitivo-conductual de la adicción a la cocaína: Especificidad de los trastornos de la personalidadbibliuned:Psicopat-2015-20-2-5010El objetivo de este estudio fue conocer la relevancia y relación de variables de interacción social con el riesgo de abandono prematuro del tratamiento, el nivel de ajuste psicológico y la calidad de vida, analizando las diferencias que puedan debers010772<a class="citation_author_name" title="Navegar por nombre de Autor de Martínez-González, José Miguel" href="/fez/list/author/Martínez-González, José Miguel/">Martínez-González, José Miguel</a>, <a class="citation_author_name" title="Navegar por nombre de Autor de Albein-Urios, Natalia" href="/fez/list/author/Albein-Urios, Natalia/">Albein-Urios, Natalia</a>, <a class="citation_author_name" title="Navegar por nombre de Autor de Lozano-Rojas, Oscar" href="/fez/list/author/Lozano-Rojas, Oscar/">Lozano-Rojas, Oscar</a> y <a class="citation_author_name" title="Navegar por nombre de Autor de Verdejo-García, Antonio" href="/fez/list/author/Verdejo-García, Antonio/">Verdejo-García, Antonio</a> . (<span class="citation_date">2015</span>) <a class="citation_title" title="Click para ver : Variables de interés clínico en el tratamiento cognitivo-conductual de la adicción a la cocaína: Especificidad de los trastornos de la personalidad" href="/fez/view/bibliuned:Psicopat-2015-20-2-5010">Variables de interés clínico en el tratamiento cognitivo-conductual de la adicción a la cocaína: Especificidad de los trastornos de la personalidad</a>. RecordArtículo de revistaPublishedPsicologíaMartínez-González, José MiguelAlbein-Urios, NataliaLozano-Rojas, OscarVerdejo-García, AntonioRevista de Psicopatología y Psicología Clínicabibliuned:Psicopat-2015-20-2-5010http://e-spacio.uned.es/fez/view/bibliuned:Psicopat-2015-20-2-5010115123220spaVariables of clinical interest in the cognitive behavioral treatment of cocaine addiction: The specifi city of personality disordersVariables_interes_clinico.pdfpresmd_Variables_interes_clinico.xml1136-5420, EISSN: 2254-6057bibliuned:Psicopat-2015-20-2bibliuned:Setarticulobibliuned:SetopenaireRevista de psicopatología y psicología clínica. Año 2015, vol. 20, n. 2Set de artículoSet de openairehttp://creativecommons.org/licenses/by-nc-nd/4.0Licencia de acceso Creative CommonsMartínez-GonzálezAcceso abierto10.5944/rppc.vol.20.num.2.2015.151660.5346615334232016-11-01T00:00:00Z12024-03-21T05:16:06Z2024-03-21T05:16:06ZExposure to increased levels of estradiol during development can have long-term effects on the response to undernutrition in female ratsbibliuned:DptoPSIBIO-FPSI-Articulos-Mepinos-0002Objectives: Undernutrition during development alters the expression of peptides that control energy expenditure and feeding behavior. Estrogens can also modulate these peptides. Here we analyzed whether early postnatal administration of estradiol modulates the effects of undernutrition on neuroendocrine parameters in adult female Wistar rats. Methods: Control rats were fed a control diet. Undernourished pups were submitted to a restricted diet with half of the undernourished rats receiving 0.4 mg/kg s.c. of estradiol benzoate (EB) from postnatal day (P) 6 until P13. Quantitative real-time PCR was performed to determine expression in the hypothalamus of Agouti-related peptide (AgRP), proopiomelanocortin (POMC), neuropeptide Y (NPY) and cocaine- and amphetamine-regulated transcript (CART). Plasma estradiol, testosterone and adiponectin levels were measured by ELISA. Total and acylated ghrelin levels were measured in plasma by RIA. Results: Undernourishment decreased body weight, fat mass, plasma leptin and insulin levels and hypothalamic POMC mRNA levels. An increase in orexigenic signals AgRP and NPY mRNA levels, and in plasma adiponectin levels were found in undernourished animals. Early postnatal treatment with EB to undernourished female rats reversed the effects of undernutrition on adult hypothalamic POMC mRNA levels. In addition, neonatal EB treatment to undernourished females significantly decreased adult plasma testosterone, estradiol and acylated ghrelin levels. Discussion: Our results suggest that increased estradiol during a critical period of development has the capacity to modulate the alterations that undernutrition produces on energy metabolism.0262<a class="citation_author_name" title="Navegar por nombre de Autor de Carrillo, Beatriz" href="/fez/list/author/Carrillo, Beatriz/">Carrillo, Beatriz</a>, <a class="citation_author_name" title="Navegar por nombre de Autor de Collado, Paloma" href="/fez/list/author/Collado, Paloma/">Collado, Paloma</a>, <a class="citation_author_name" title="Navegar por nombre de Autor de Díaz, Francisca" href="/fez/list/author/Díaz, Francisca/">Díaz, Francisca</a>, <a class="citation_author_name" title="Navegar por nombre de Autor de Chowen, Julie A" href="/fez/list/author/Chowen, Julie A/">Chowen, Julie A</a> y <a class="citation_author_name" title="Navegar por nombre de Autor de Pinos, Helena" href="/fez/list/author/Pinos, Helena/">Pinos, Helena</a> . (<span class="citation_date">2016</span>) <a class="citation_title" title="Click para ver : Exposure to increased levels of estradiol during development can have long-term effects on the response to undernutrition in female rats" href="/fez/view/bibliuned:DptoPSIBIO-FPSI-Articulos-Mepinos-0002">Exposure to increased levels of estradiol during development can have long-term effects on the response to undernutrition in female rats</a>. RecordArtículo de revistaPublishedBiologíaPsicologíaThe registered version of this paper, first published in Nutritional Neuroscience (2016)199, is available online at the publisher's website: Taylor and Francis Group, https://doi.org/10.1179/1476830515Y.0000000012Taylor and Francis GroupCarrillo, BeatrizCollado, PalomaDíaz, FranciscaChowen, Julie APinos, Helena1Nutritional Neurosciencebibliuned:DptoPSIBIO-FPSI-Articulos-Mepinos-0002http://e-spacio.uned.es/fez/view/bibliuned:DptoPSIBIO-FPSI-Articulos-Mepinos-0002919engPinos-Sanchez_Maria_Elena_Nutritional-neuro.pdfpresmd_Pinos-Sanchez_Maria_Elena_Nutritional-neuro.xml1476-8305bibliuned:DptoPSIBIO-FPSI-Articulosbibliuned:Setarticulobibliuned:SetopenaireDepartamento de Psicobiología (UNED). ArtículosSet de artículoSet de openairehttps://creativecommons.org/licenses/by-nc-nd/4.0/es/License Creative CommonsCarrilloAcceso abiertohttps://doi.org/10.1179/1476830515Y.00000000120.4638905234232019-01-01T00:00:00Z52024-02-01T05:40:49Z2024-02-01T05:40:49ZCentral nucleus of the amygdala as a common substrate of the incubation of drug and natural reinforcer seekingbibliuned:DptoPSIBIO-FPSI-Articulos-Mucha-0001Relapse into drug use is a major problem faced by recovering addicts. In humans, an intensification of the desire for the drug induced by environmental cues—incubation of drug craving—has been observed. In rodents, this phenomenon has been modeled by studying drug seeking under extinction after different times of drug withdrawal (or using a natural reinforcer). Although much progress has been made, an integrated approach simultaneously studying different drug classes and natural reward and examining different brain regions is lacking. Lewis rats were used to study the effects of cocaine, heroin, and sucrose seeking incubation on six key brain regions: the nucleus accumbens shell/core, central/basolateral amygdala, and dorsomedial/ventromedial prefrontal cortex. We analyzed PSD95 and gephyrin protein levels, gene expression of glutamatergic, GABAergic and endocannabinoid elements, and amino acid transmitter levels. The relationships between the areas studied were examined by Structural Equation Modelling. Pathways from medial prefrontal cortex and basolateral complex of the amygdala to central nucleus of the amygdala, but not to the nucleus accumbens, were identified as common elements involved in the incubation phenomenon for different substances. These results suggest a key role for the central nucleus of amygdala and its cortical and amygdalar afferences in the incubation phenomenon, and we suggest that by virtue of its regulatory effects on glutamatergic and GABAergic dynamics within amygdalar circuits, the endocannabinoid system might be a potential target to develop medications that are effective in the context of relapse.0192<a class="citation_author_name" title="Navegar por nombre de Autor de Roura‐Martínez, David" href="/fez/list/author/Roura‐Martínez, David/">Roura‐Martínez, David</a>, <a class="citation_author_name" title="Navegar por nombre de Autor de Ucha, Marcos" href="/fez/list/author/Ucha, Marcos/">Ucha, Marcos</a>, <a class="citation_author_name" title="Navegar por nombre de Autor de Orihuel, Javier" href="/fez/list/author/Orihuel, Javier/">Orihuel, Javier</a> y <a class="citation_author_name" title="Navegar por nombre de Autor de et al." href="/fez/list/author/et al./">et al.</a> . (<span class="citation_date">2019</span>) <a class="citation_title" title="Click para ver : Central nucleus of the amygdala as a common substrate of the incubation of drug and natural reinforcer seeking" href="/fez/view/bibliuned:DptoPSIBIO-FPSI-Articulos-Mucha-0001">Central nucleus of the amygdala as a common substrate of the incubation of drug and natural reinforcer seeking</a>. RecordArtículo de revistaPublishedPsicologíaLa versión registrada de este artículo, publicado por primera vez en Addiction Biology, está disponible en línea en el sitio web del editor: WILEY, https://doi.org/10.1111/adb.12706WILEYRoura‐Martínez, DavidUcha, MarcosOrihuel, Javieret al.1Addiction Biologybibliuned:DptoPSIBIO-FPSI-Articulos-Mucha-0001http://e-spacio.uned.es/fez/view/bibliuned:DptoPSIBIO-FPSI-Articulos-Mucha-0001112engUcha_Tortuero_Marcos_CentralNucleus.pdfpresmd_Ucha_Tortuero_Marcos_CentralNucleus.xml1369-1600, 1355-6215bibliuned:DptoPSIBIO-FPSI-Articulosbibliuned:Setarticulobibliuned:SetopenaireDepartamento de Psicobiología (UNED). ArtículosSet de artículoSet de openairehttp://creativecommons.org/licenses/by-nc-nd/4.0Licencia Creative CommonsRoura‐MartínezAcceso abiertohttps://doi.org/10.1111/adb.127060.4638905234232022-01-01T00:00:00Z72024-02-01T06:33:30Z2024-02-01T06:33:30ZEffects of heroin self‑administration and forced withdrawal on the expression of genes related to the mTOR network in the basolateral complex of the amygdala of male Lewis ratsbibliuned:DptoPSIBIO-FPSI-Articulos-Mucha-0003Rationale The development of substance use disorders involves long-lasting adaptations in specific brain areas that result in an elevated risk of relapse. Some of these adaptations are regulated by the mTOR network, a signalling system that integrates extracellular and intracellular stimuli and modulates several processes related to plasticity. While the role of the mTOR network in cocaine- and alcohol-related disorders is well established, little is known about its participation in opiate use disorders. Objectives To use a heroin self-administration and a withdrawal protocol that induce incubation of heroin-seeking in male rats and study the associated effects on the expression of several genes related to the mTOR system and, in the specific case of Rictor, its respective translated protein and phosphorylation. Results We found that heroin self-administration elicited an increase in the expression of the genes Igf1r, Igf2r, Akt2 and Gsk3a in the basolateral complex of the amygdala, which was not as evident at 30 days of withdrawal. We also found an increase in the expression of Rictor (a protein of the mTOR complex 2) after heroin self-administration compared to the saline group, which was occluded at the 30-day withdrawal period. The activation levels of Rictor, measured by the phosphorylation rate, were also reduced after heroin self-administration, an effect that seemed more apparent in the protracted withdrawal group. Conclusions These results suggest that heroin self-administration under extended access conditions modifies the expression profile of activators and components of the mTOR complexes and show a putative irresponsive mTOR complex 2 after withdrawal from heroin use.0192<a class="citation_author_name" title="Navegar por nombre de Autor de Ucha, Marcos" href="/fez/list/author/Ucha, Marcos/">Ucha, Marcos</a>, <a class="citation_author_name" title="Navegar por nombre de Autor de Roura‑Martínez, David" href="/fez/list/author/Roura‑Martínez, David/">Roura‑Martínez, David</a>, <a class="citation_author_name" title="Navegar por nombre de Autor de Santos‑Toscano, Raquel" href="/fez/list/author/Santos‑Toscano, Raquel/">Santos‑Toscano, Raquel</a> y <a class="citation_author_name" title="Navegar por nombre de Autor de et al." href="/fez/list/author/et al./">et al.</a> . (<span class="citation_date">2022</span>) <a class="citation_title" title="Click para ver : Effects of heroin self‑administration and forced withdrawal on the expression of genes related to the mTOR network in the basolateral complex of the amygdala of male Lewis rats" href="/fez/view/bibliuned:DptoPSIBIO-FPSI-Articulos-Mucha-0003">Effects of heroin self‑administration and forced withdrawal on the expression of genes related to the mTOR network in the basolateral complex of the amygdala of male Lewis rats</a>. RecordArtículo de revistaPublishedPsicologíaLa versión registrada de este artículo, publicado por primera vez en Psychopharmacology, está disponible en línea en el sitio web del editor: Springer, https://doi.org/10.1007/s00213-022-06144-2SpringerUcha, MarcosRoura‑Martínez, DavidSantos‑Toscano, Raquelet al.1Psychopharmacologybibliuned:DptoPSIBIO-FPSI-Articulos-Mucha-0003http://e-spacio.uned.es/fez/view/bibliuned:DptoPSIBIO-FPSI-Articulos-Mucha-000325592571239engUcha_Tortuero_Marcos_HeroinAdministration.pdfpresmd_Ucha_Tortuero_Marcos_HeroinAdministration.xml0033-3158, eISSN 1432-2072bibliuned:DptoPSIBIO-FPSI-Articulosbibliuned:Setarticulobibliuned:SetopenaireDepartamento de Psicobiología (UNED). ArtículosSet de artículoSet de openairehttp://creativecommons.org/licenses/by/4.0Licencia Creative CommonsUchaAcceso abiertohttps://doi.org/10.1007/s00213-022-06144-20.39311957772442875875