08false100true score desc 2gaptrue5mapcontentxmltrue50object_type_i,object_type_i_lookup,coverage_period_mt,geographic_area_mt,geographic_coordinates_mt,author_role_mt,contributor_role_mt,org_id_mt,org_role_mt,supervisor_mt,supervisor_id_mi,supervisor_id_mi_lookup,fields_of_research_mi,fields_of_research_mi_lookup,display_type_i,display_type_i_lookup,seo_code_mi,seo_code_mi_lookup,copyright_i,license_i,license_i_lookup,oa_compliance_t,oa_notes_t,grant_id_t,funding_body_t,description_of_resource_t,software_required_t,project_description_t,keywords_mt,project_name_t,project_id_t,isdatasetof_mt,isdatasetof_mt_lookup,notes_t,date_dt,xsd_display_option_mi,xsd_display_option_mi_lookup,file_downloads_i,created_date_dt,updated_date_dt,research_program_mt,title_t,depositor_i,isderivationof_mt,assigned_user_id_mt,assigned_group_id_mi,assigned_group_id_mi_lookup,isdatacomponentof_mt,isannotationof_mt,author_id_mi,author_id_mi_lookup,alternative_title_mt,pid_t,publisher_t,author_mt,contributor_mt,contributor_id_mi,contributor_id_mi_lookup,refereed_i,series_t,journal_name_t,newspaper_t,conference_name_t,book_title_t,identifier_mt,edition_t,subject_mi,subject_mi_lookup,place_of_publication_t,start_page_t,end_page_t,chapter_number_t,issue_number_t,volume_number_t,conference_dates_t,conference_location_t,patent_number_t,country_of_issue_t,description_t,date_available_dt,language_mt,phonetic_title_t,language_of_title_mt,translated_title_t,phonetic_journal_name_t,translated_journal_name_t,phonetic_book_title_t,translated_book_title_t,phonetic_newspaper_t,file_attachment_name_mt,translated_newspaper_t,phonetic_conference_name_t,translated_conference_name_t,issn_mt,isbn_mt,isi_loc_t,prn_t,output_availability_t,na_explanation_t,sensitivity_explanation_t,file_attachment_content_mt,org_unit_name_t,org_name_t,report_number_t,sequence_i,genre_t,genre_type_t,formatted_title_t,formatted_abstract_t,parent_publication_t,convener_t,ismemberof_mt,ismemberof_mt_lookup,link_mt,link_description_mt,rights_t,views_i,scopus_id_t,thomson_citation_count_i,gs_citation_count_i,gs_cited_by_link_t,scopus_citation_count_i,status_i,status_i_lookup,first_author_in_document_derived_t,first_author_in_fez_derived_t,ands_collection_type_t,start_date_dt,end_date_dt,access_conditions_t,extent_t,contact_details_email_mt,contact_details_physical_mt,loc_subject_heading_mt,depositor_affiliation_i,surrounding_features_mt,condition_mt,style_mt,period_mt,category_mt,subcategory_mt,structural_systems_mt,adt_id_t,subtype_t,language_of_parent_title_t,proceedings_title_t,file_description_mt,herdc_code_i,herdc_code_i_lookup,herdc_status_i,herdc_status_i_lookup,institutional_status_i,institutional_status_i_lookup,herdc_notes_t,follow_up_flags_i,follow_up_flags_i_lookup,follow_up_flags_imu_i,follow_up_flags_imu_i_lookup,scopus_doc_type_t,scopus_doc_type_t_lookup,wok_doc_type_t,wok_doc_type_t_lookup,conference_id_i,total_chapters_t,publisher_id_i,translated_proceedings_title_t,native_script_title_t,roman_script_title_t,native_script_book_title_t,roman_script_book_title_t,native_script_journal_name_t,roman_script_journal_name_t,native_script_conference_name_t,roman_script_conference_name_t,total_pages_t,native_script_proceedings_title_t,roman_script_proceedings_title_t,language_of_book_title_mt,language_of_journal_name_mt,language_of_proceedings_title_mt,doi_t,author_count_t,collection_year_dt,location_mt,building_materials_mt,architectural_features_mt,interior_features_mt,sherpa_colour_t,ain_detail_t,rj_2010_rank_t,rj_2010_title_t,rj_2012_rank_t,rj_2012_title_t,rc_2010_rank_t,rc_2010_title_t,herdc_code_description_t,score,citation_t1true60 (clinical trials AND ismemberof_mt:bibliuned\:Setarticulo AND status_i:(2)) 6display_type_idisplay_type_i_lookup_exactkeywords_mftdate_year_tauthor_id_miauthor_id_mi_lookup_exactauthor_mftjournal_name_t_ftsubject_misubject_mi_lookup_exactgenre_type_t_ftismemberof_mftismemberof_mt_lookup_exactsubtype_t_ftscopus_doc_type_t_ftscopus_doc_type_t_lookup_exact(_authlister_t:(1)) AND (status_i:(2)) 34232013-06-04T00:00:00Z14062013-06-04T21:17:28Z2015-10-31T04:36:09ZOn the impartiality of early British clinical trialsbibliuned:500681Did the impartiality of clinical trials play any role in their acceptance as regulatory standards for the safety and efficacy of drugs? According to the standard account of early British trials in the 1930s and 1940s, their impartiality was just rhetorica06032<a class="citation_author_name" title="Navegar por nombre de Autor de Teira Serrano, David" href="/fez/list/author/Teira Serrano, David/">Teira Serrano, David</a> . (<span class="citation_date">2013</span>) <a class="citation_title" title="Click para ver : On the impartiality of early British clinical trials" href="/fez/view/bibliuned:500681">On the impartiality of early British clinical trials</a>. RecordArtículo de revistaPublishedclinical trials, Streptomycin, fair test, impartialityTeira Serrano, Davidbibliuned:500681ImpartialityBritishTrialsBlind.pdfbibliuned:81bibliuned:Setopenairebibliuned:SetarticuloDepartamento Lógica, Historia, Filosofía de la Ciencia (UNED). ArtículosSet de openaireSet de artículohttp://creativecommons.org/licenses/by-nc-nd/4.0Licencia Creative CommonsTeira SerranoAcceso abierto1.847095734232006-01-01T00:00:00Z4862007-11-07T14:03:35Z2017-09-26T22:49:24ZNormas éticas y estadísticas en la justificación de los ensayos clínicos aleatorizadosbibliuned:579In this paper we analyse how to combine the statistical justification of the results obtained in a randomised clinical trial and the ethical and social arguments that support its implementation. We try to show how this justification varies according to the view on probability we adopt and the different ethical cases that can be made to sustain it. We will see that both the frequentist and the Bayesian approaches to the design of clinical trials are equally defensible on these grounds. We will defend that to be socially acceptable both approaches must meet an impartiality requirement, which is best served by the technique of randomisation.09212<a class="citation_author_name" title="Navegar por nombre de Autor de García Alonso, Marta" href="/fez/list/author/García Alonso, Marta/">García Alonso, Marta</a> y <a class="citation_author_name" title="Navegar por nombre de Autor de Teira Serrano, David" href="/fez/list/author/Teira Serrano, David/">Teira Serrano, David</a> . (<span class="citation_date">2006</span>) <a class="citation_title" title="Click para ver : Normas éticas y estadísticas en la justificación de los ensayos clínicos aleatorizados" href="/fez/view/bibliuned:579">Normas éticas y estadísticas en la justificación de los ensayos clínicos aleatorizados</a>. RecordArtículo de revistaPublishedFilosofíaGarcía Alonso, MartaTeira Serrano, David1bibliuned:579<dc:identifier>http://e-spacio.uned.es/fez/view.php?pid=bibliuned:579spaCritica_Publicado.pdfbibliuned:577bibliuned:Setopenairebibliuned:SetarticuloDepartamento de Filosofía y Filosofía Moral y Política (UNED). ArtículosSet de openaireSet de artículohttp://creativecommons.org/licenses/by-nc-nd/4.0Licencia Creative CommonsGarcía AlonsoAcceso abierto1.065212634232018-06-30T00:00:00Z42024-01-30T09:20:42Z2024-01-30T12:29:16ZMelodic intonation therapy in post-stroke nonfluent aphasia: a randomized pilot trialbibliuned:DptoPBII-FPSI-Articulos-Glubrini-0004Objective: To collect data to estimate the sample size of a definitive randomized controlled trial to evaluate the effects of Melodic Intonation Therapy in post-stroke nonfluent aphasia. Design: A randomized, crossover, interventional pilot trial. Setting: Departments of Neurology and Rehabilitation from a university general hospital. Participants: Stroke survivors with post-stroke nonfluent aphasia. Interventions: Patients randomized to group 1 had treatment with Melodic Intonation Therapy first (12 sessions over six weeks) followed by no treatment; the patients in group 2 started active treatment between three and six months after their inclusion in the study, serving as waiting list controls for the first phase. Main measures: The Communicative Activity Log (CAL) questionnaire and the Boston Diagnostic Aphasia Examination (BDAE) were evaluated at baseline, and at six and 12 weeks. Results: Twenty patients were included. Four of the patients allocated to group 2 crossed over to group 1, receiving the treatment at first. Intention-to-treat analysis: after adjustment for baseline scores, the mean difference in the CAL evaluation from baseline in the treated group was 8.5 points (95% confidence interval (CI), 0.11–17.0; P = .043), with no significant change in any of the BDAE sections. Per-protocol analysis showed similar results with a clear treatment effect (P = .043) on the CAL. Conclusion: Melodic Intonation Therapy might have a positive effect on the communication skills of stroke survivors with nonfluent aphasia as measured by the CAL questionnaire. A full-scale trial with at least 27 patients per group is necessary to confirm these results.0242<a class="citation_author_name" title="Navegar por nombre de Autor de Haro-Martínez, Ana M." href="/fez/list/author/Haro-Martínez, Ana M./">Haro-Martínez, Ana M.</a>, <a class="citation_author_name" title="Navegar por nombre de Autor de Lubrini, Genny" href="/fez/list/author/Lubrini, Genny/">Lubrini, Genny</a>, <a class="citation_author_name" title="Navegar por nombre de Autor de Madero-Jarabo, Rosario" href="/fez/list/author/Madero-Jarabo, Rosario/">Madero-Jarabo, Rosario</a>, <a class="citation_author_name" title="Navegar por nombre de Autor de Díez-Tejedor, Exuperio" href="/fez/list/author/Díez-Tejedor, Exuperio/">Díez-Tejedor, Exuperio</a> y <a class="citation_author_name" title="Navegar por nombre de Autor de Fuentes, Blanca" href="/fez/list/author/Fuentes, Blanca/">Fuentes, Blanca</a> . (<span class="citation_date">2018</span>) <a class="citation_title" title="Click para ver : Melodic intonation therapy in post-stroke nonfluent aphasia: a randomized pilot trial" href="/fez/view/bibliuned:DptoPBII-FPSI-Articulos-Glubrini-0004">Melodic intonation therapy in post-stroke nonfluent aphasia: a randomized pilot trial</a>. RecordArtículo de revistaPublishedPsicologíaLa versión registrada de este artículo, publicado por primera vez en Clinical Rehabilitation, está disponible en línea en el sitio web del editor: SAGE https://doi.org/10.1177/0269215518791004SAGEHaro-Martínez, Ana M.Lubrini, GennyMadero-Jarabo, RosarioDíez-Tejedor, ExuperioFuentes, BlancaClinical Rehabilitationbibliuned:DptoPBII-FPSI-Articulos-Glubrini-0004http://e-spacio.uned.es/fez/view/bibliuned:DptoPBII-FPSI-Articulos-Glubrini-0004445333engLubrini_Genny_Melodic_intonation_therapy.pdfpresmd_Lubrini_Genny_Melodic_intonation_therapy.xml1477-0873bibliuned:DptoPBII-FPSI-Articulosbibliuned:Setarticulobibliuned:SetopenaireDepartamento de Psicología Básica II. ArtículosSet de artículoSet de openairehttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.esLicencia Creative CommonsHaro-MartínezAcceso abierto10.1177/02692155187910041.027320734232020-01-01T00:00:00Z352024-01-23T10:37:33Z2024-01-23T10:37:37ZEfficacy of a two-session repetitive negative thinking-focused acceptance and commitment therapy (ACT) protocol for depression and generalized anxiety disorder: A randomized waitlist control trialbibliuned:DptoMCC-FPSI-Articulos-JCsuarezThis parallel randomized controlled trial aimed to evaluate the effect of acceptance and commitment therapy (ACT) focused on disrupting repetitive negative thinking (RNT) versus a waitlist control (WLC) in the treatment of depression and generalized anxiety disorder (GAD). Forty-eight participants with a main diagnosis of depression and/or GAD were allocated by means of simple randomization to a 2-session RNT-focused ACT intervention or to the WLC. The primary outcomes were emotional symptoms as measured by the Depression, Anxiety, and Stress Scales–21. Process outcomes included ACT- and RNT-related measures: general RNT, experiential avoidance, cognitive fusion, values, and generalized pliance. At the 1-month follow-up, linear mixed effects models showed that the intervention was efficacious in reducing emotional symptoms (d = 2.42, 95% confidence interval [1.64, 3.19]), with 94.12% of participants in the RNT-focused ACT condition showing clinically significant change in the Depression, Anxiety, and Stress Scales–21 total scores versus 9.09% in the WLC condition (70% vs. 8% in intention-to-treat analysis). The intervention effects were maintained at the 3-month follow-up. No adverse events were found. A very brief RNT-focused ACT intervention was highly effective in the treatment of depression and GAD. (PsycInfo Database Record (c) 2020 APA, all rights reserved)0382<a class="citation_author_name" title="Navegar por nombre de Autor de Ruiz, Francisco J." href="/fez/list/author/Ruiz, Francisco J./">Ruiz, Francisco J.</a>, <a class="citation_author_name" title="Navegar por nombre de Autor de Peña-Vargas, Andrés" href="/fez/list/author/Peña-Vargas, Andrés/">Peña-Vargas, Andrés</a>, <a class="citation_author_name" title="Navegar por nombre de Autor de Ramírez, Eduar S." href="/fez/list/author/Ramírez, Eduar S./">Ramírez, Eduar S.</a>, <a class="citation_author_name" title="Navegar por nombre de Autor de Suárez-Falcón, Juan C." href="/fez/list/author/Suárez-Falcón, Juan C./">Suárez-Falcón, Juan C.</a>, <a class="citation_author_name" title="Navegar por nombre de Autor de García-Martín, María B." href="/fez/list/author/García-Martín, María B./">García-Martín, María B.</a>, <a class="citation_author_name" title="Navegar por nombre de Autor de García-Beltrán, Diana M." href="/fez/list/author/García-Beltrán, Diana M./">García-Beltrán, Diana M.</a>, <a class="citation_author_name" title="Navegar por nombre de Autor de Henao, Ángela M." href="/fez/list/author/Henao, Ángela M./">Henao, Ángela M.</a>, <a class="citation_author_name" title="Navegar por nombre de Autor de Monroy-Cifuentes, Andrea" href="/fez/list/author/Monroy-Cifuentes, Andrea/">Monroy-Cifuentes, Andrea</a> y <a class="citation_author_name" title="Navegar por nombre de Autor de Sánchez, Pili D." href="/fez/list/author/Sánchez, Pili D./">Sánchez, Pili D.</a> . (<span class="citation_date">2020</span>) <a class="citation_title" title="Click para ver : Efficacy of a two-session repetitive negative thinking-focused acceptance and commitment therapy (ACT) protocol for depression and generalized anxiety disorder: A randomized waitlist control trial" href="/fez/view/bibliuned:DptoMCC-FPSI-Articulos-JCsuarez">Efficacy of a two-session repetitive negative thinking-focused acceptance and commitment therapy (ACT) protocol for depression and generalized anxiety disorder: A randomized waitlist control trial</a>. RecordArtículo de revistaPublishedPsicologíaLa versión registrada de este artículo, publicado por primera vez en Psychotherapy, está disponible en línea en el sitio web del editor: https://doi.org/10.1037/pst0000273American Psychological AssociationRuiz, Francisco J.Peña-Vargas, AndrésRamírez, Eduar S.Suárez-Falcón, Juan C.García-Martín, María B.García-Beltrán, Diana M.Henao, Ángela M.Monroy-Cifuentes, AndreaSánchez, Pili D.Psychotherapy, 57(3), 444–456.bibliuned:DptoMCC-FPSI-Articulos-JCsuarezhttp://e-spacio.uned.es/fez/viewbibliuned:DptoMCC-FPSI-Articulos-JCsuarez444456357engSu__rez-Falc__n_Juan_Carlos_Efficacy_protocolo.pdfpresmd_Su__rez-Falc__n_Juan_Carlos_Efficacy_protocolo.xml0033-3204 - eISSN 1939-1536bibliuned:DptoMCC-FPSI-Articulosbibliuned:Setarticulobibliuned:SetopenaireDepartamento de Metodología de las Ciencias del Comportamiento (UNED). ArtículosSet de artículoSet de openairehttps://creativecommons.org/licenses/by/4.0/Licencia Creative CommonsRuizAcceso abiertohttps://doi.org/10.1037/pst00002730.7303812534232023-04-20T00:00:00Z62024-01-26T12:50:52Z2024-01-26T12:54:48ZMaternal Supplementation with N-Acetylcysteine Modulates the Microbiota-Gut-Brain Axis in Offspring of the Poly I:C Rat Model of Schizophrenia.bibliuned:DptoFMyF-FCIE-Articulos-Csantamarta-0008The microbiota-gut-brain axis is a complex interconnected system altered in schizophrenia. The antioxidant N-acetylcysteine (NAC) has been proposed as an adjunctive therapy to antipsychotics in clinical trials, but its role in the microbiota-gut-brain axis has not been sufficiently explored. We aimed to describe the effect of NAC administration during pregnancy on the gut-brain axis in the offspring from the maternal immune stimulation (MIS) animal model of schizophrenia. Pregnant Wistar rats were treated with PolyI:C/Saline. Six groups of animals were studied according to the study factors: phenotype (Saline, MIS) and treatment (no NAC, NAC 7 days, NAC 21 days). Offspring were subjected to the novel object recognition test and were scanned using MRI. Caecum contents were used for metagenomics 16S rRNA sequencing. NAC treatment prevented hippocampal volume reduction and long-term memory deficits in MIS-offspring. In addition, MIS-animals showed lower bacterial richness, which was prevented by NAC. Moreover, NAC7/NAC21 treatments resulted in a reduction of proinflammatory taxons in MIS-animals and an increase in taxa known to produce anti-inflammatory metabolites. Early approaches, like this one, with anti-inflammatory/anti-oxidative compounds, especially in neurodevelopmental disorders with an inflammatory/oxidative basis, may be useful in modulating bacterial microbiota, hippocampal size, as well as hippocampal-based memory impairments.0462<a class="citation_author_name" title="Navegar por nombre de Autor de Romero-Miguel, D." href="/fez/list/author/Romero-Miguel, D./">Romero-Miguel, D.</a>, <a class="citation_author_name" title="Navegar por nombre de Autor de Casquero-Veiga, M." href="/fez/list/author/Casquero-Veiga, M./">Casquero-Veiga, M.</a>, <a class="citation_author_name" title="Navegar por nombre de Autor de Fernández, J." href="/fez/list/author/Fernández, J./">Fernández, J.</a>, <a class="citation_author_name" title="Navegar por nombre de Autor de Lamanna-Rama, N." href="/fez/list/author/Lamanna-Rama, N./">Lamanna-Rama, N.</a>, <a class="citation_author_name" title="Navegar por nombre de Autor de Gómez-Rangel, V." href="/fez/list/author/Gómez-Rangel, V./">Gómez-Rangel, V.</a>, <a class="citation_author_name" title="Navegar por nombre de Autor de Gálvez-Robleño, C." href="/fez/list/author/Gálvez-Robleño, C./">Gálvez-Robleño, C.</a>, <a class="citation_author_name" title="Navegar por nombre de Autor de Santa Marta Pastrana, Cristina" href="/fez/list/author/Santa Marta Pastrana, Cristina/">Santa Marta Pastrana, Cristina</a>, <a class="citation_author_name" title="Navegar por nombre de Autor de Villar, C. J." href="/fez/list/author/Villar, C. J./">Villar, C. J.</a>, <a class="citation_author_name" title="Navegar por nombre de Autor de Lombó, F." href="/fez/list/author/Lombó, F./">Lombó, F.</a>, <a class="citation_author_name" title="Navegar por nombre de Autor de Abalo, R." href="/fez/list/author/Abalo, R./">Abalo, R.</a>, <a class="citation_author_name" title="Navegar por nombre de Autor de Desco, M." href="/fez/list/author/Desco, M./">Desco, M.</a> y <a class="citation_author_name" title="Navegar por nombre de Autor de Soto-Montenegro, M. L." href="/fez/list/author/Soto-Montenegro, M. L./">Soto-Montenegro, M. L.</a> . (<span class="citation_date">2023</span>) <a class="citation_title" title="Click para ver : Maternal Supplementation with N-Acetylcysteine Modulates the Microbiota-Gut-Brain Axis in Offspring of the Poly I:C Rat Model of Schizophrenia." href="/fez/view/bibliuned:DptoFMyF-FCIE-Articulos-Csantamarta-0008">Maternal Supplementation with N-Acetylcysteine Modulates the Microbiota-Gut-Brain Axis in Offspring of the Poly I:C Rat Model of Schizophrenia.</a>. RecordArtículo de revistaPublishedZoologíaLa versión registrada de este artículo, publicado por primera vez en Antioxidants, está disponible en línea en el sitio web del editor: MDPI https://doi.org/10.3390/ANTIOX12040970MDPIRomero-Miguel, D.Casquero-Veiga, M.Fernández, J.Lamanna-Rama, N.Gómez-Rangel, V.Gálvez-Robleño, C.Santa Marta Pastrana, CristinaVillar, C. J.Lombó, F.Abalo, R.Desco, M.Soto-Montenegro, M. L.Antioxidantsbibliuned:DptoFMyF-FCIE-Articulos-Csantamarta-0008http://e-spacio.uned.es/fez/view/bibliuned:DptoFMyF-FCIE-Articulos-Csantamarta-0008412engSANTA_MARTA_antioxidants-12-00970.pdfpresmd_SANTA_MARTA_antioxidants-12-00970.xml2076-3921bibliuned:DptoFMyF-FCIE-Articulosbibliuned:Setarticulobibliuned:SetopenaireDepartamento de Física matemática y de Fluidos. ArtículosSet de artículoSet de openairehttps://creativecommons.org/licenses/by/4.0/deed.esLicencia Creative CommonsRomero-MiguelAcceso abierto10.3390/ANTIOX120409700.556801655225555