G Protein-Coupled Estrogen Receptor Immunoreactivity Fluctuates During the Estrous Cycle and Show Sex Differences in the Amygdala and Dorsal Hippocampus

Llorente, Ricardo, Marraudino, Marilena, Carrillo, Beatriz, Bonaldo, Brigitta, Simon-Areces, Julia, Abellanas-Pérez, Pedro, Rivero-Aguilar, Marina, Fernandez-Garcia, Jose M, Pinos, Helena, Garcia-Segura, Luis M, Collado, Paloma y Grassi, Daniela . (2020) G Protein-Coupled Estrogen Receptor Immunoreactivity Fluctuates During the Estrous Cycle and Show Sex Differences in the Amygdala and Dorsal Hippocampus. Frontiers in Endocrinology 11 (2020)

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Título G Protein-Coupled Estrogen Receptor Immunoreactivity Fluctuates During the Estrous Cycle and Show Sex Differences in the Amygdala and Dorsal Hippocampus
Autor(es) Llorente, Ricardo
Marraudino, Marilena
Carrillo, Beatriz
Bonaldo, Brigitta
Simon-Areces, Julia
Abellanas-Pérez, Pedro
Rivero-Aguilar, Marina
Fernandez-Garcia, Jose M
Pinos, Helena
Garcia-Segura, Luis M
Collado, Paloma
Grassi, Daniela
Materia(s) Psicología
Resumen G protein-coupled estrogen receptor (GPER) in the amygdala and the dorsal hippocampus mediates actions of estradiol on anxiety, social recognition and spatial memory. In addition, GPER participates in the estrogenic regulation of synaptic function in the amygdala and in the process of adult neurogenesis in the dentate gyrus. While the distribution of the canonical estrogen receptors α and β in the amygdala and dorsal hippocampus are well characterized, little is known about the regional distribution of GPER in these brain regions and whether this distribution is affected by sex or the stages of the estrous cycle. In this study we performed a morphometric analysis of GPER immunoreactivity in the posterodorsal medial, anteroventral medial, basolateral, basomedial and central subdivisions of the amygdala and in all the histological layers of CA1 and the dentate gyrus of the dorsal hippocampal formation. The number of GPER immunoreactive cells was estimated in these different structures. GPER immunoreactivity was detected in all the assessed subdivisions of the amygdaloid nucleus and dorsal hippocampal formation. The number of GPER immunoreactive cells was higher in males than in estrus females in the central (P = 0.001) and the posterodorsal medial amygdala (P < 0.05); higher in males than in diestrus females in the strata orients (P < 0.01) and radiatum-lacunosum-moleculare (P < 0.05) of CA1-CA3 and in the molecular layer of the dentate gyrus (P < 0.01); higher in diestrus females than in males in the basolateral amygdala (P < 0.05); higher in diestrus females than in estrus females in the central (P < 0.01), posterodorsal medial (P < 0.01) and basolateral amygdala (P < 0.01) and higher in estrus females than in diestrus females in the strata oriens (P < 0.05) and radiatum-lacunosum-moleculare (P < 0.05) of CA1-CA3 and in the molecular layer (P < 0.05) and the hilus of the dentate gyrus (P < 0.05). The findings suggest that estrogenic regulation of the amygdala and hippocampus through GPER may be different in males and in females and may fluctuate during the estrous cycle.
Abstract Front Endocrinol (Lausanne) . 2020 Aug 7:11:537. doi: 10.3389/fendo.2020.00537. eCollection 2020.
Palabras clave GPER
amygdala
diestrus
estrogens
estrous cycle
estrus
hippocampus
limbic system
Editor(es) Frontiers Media
Fecha 2020
Formato application/pdf
Identificador bibliuned:DptoPSIBIO-FPSI-Articulos-Pcollado-0006
http://e-spacio.uned.es/fez/view/bibliuned:DptoPSIBIO-FPSI-Articulos-Pcollado-0006
DOI - identifier 10.3389/fendo.2020.00537
ISSN - identifier 1664-2392
Nombre de la revista Frontiers in Endocrinology
Número de Volumen 11
Publicado en la Revista Frontiers in Endocrinology 11 (2020)
Idioma eng
Versión de la publicación publishedVersion
Tipo de recurso Article
Derechos de acceso y licencia http://creativecommons.org/licenses/by/4.0
Tipo de acceso Acceso abierto
Notas adicionales The registered version of this article, first published in Frontiers in Endocrinology , is available online at the publisher's website: 10.3389/fendo.2020.00537
Notas adicionales La versión registrada de este artículo, publicado por primera vez en Frontiers in Endocrinology , está disponible en línea en el sitio web del editor: 10.3389/fendo.2020.00537

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