Blocking of Estradiol Receptors ERα, ERβ and GPER During Development, Differentially Alters Energy Metabolism in Male and Female Rats

Carrillo, Beatriz, Collado, Paloma, Díaz, Francisca, Chowen, Julie A., Grassi, Daniela y Pino, Helena . (2020) Blocking of Estradiol Receptors ERα, ERβ and GPER During Development, Differentially Alters Energy Metabolism in Male and Female Rats. Neuroscience 426 (2020) 59–68

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Título Blocking of Estradiol Receptors ERα, ERβ and GPER During Development, Differentially Alters Energy Metabolism in Male and Female Rats
Autor(es) Carrillo, Beatriz
Collado, Paloma
Díaz, Francisca
Chowen, Julie A.
Grassi, Daniela
Pino, Helena
Materia(s) Psicología
Resumen Estradiol not only participates in the regulation of energy metabolism in adulthood, but also during the first stages of life as it modulates the alterations induced by under- and over-nutrition. The objectives of the present study were to determine: 1) If estradiol is involved in the normal programming of energy metabolism in rats; 2) If there is a specific window of time for this programming and 3) If males and females are differentially vulnerable to the action of this hormone. Estrogen receptors (ER) α, ERβ and GPER were blocked by their specific antagonists MPP, PHTPP and G15, respectively, from postnatal day (P) 1 (the day of birth) to P5 or from P5 to P13. Physiological parameters such as body weight, fat depots and caloric intake were then analysed at P90. Hypothalamic AgRP, POMC, MC4R, ERα, ERβ and GPER mRNA levels and plasma levels of estradiol, were also studied. We found that blocking ER receptors from P5 to P13 significantly decreases long-term body weight in males and hypothalamic POMC mRNA levels in females. The blocking of ERs from P1 to P5 only affected plasma estradiol levels in females. The present results indicate programming actions of estradiol from P5 to P13 on body weight in male and POMC expression in female rats and emphasize the importance of including both sexes in metabolic studies. It is necessary to unravel the mechanisms that underlie the actions of estradiol on food intake, both during development and in adulthood, and to determine how this programming differentially takes place in males and females.
Palabras clave estradiol receptor alpha (ERa)
estradiol receptor beta (ERb)
G-protein-coupled estrogen receptor (GPER)
energy metabolism programming
POMC
sex differences
Editor(es) Elsevier
Fecha 2020
Formato application/pdf
Identificador bibliuned:DptoPSIBIO-FPSI-Articulos-Pcollado-0005
http://e-spacio.uned.es/fez/view/bibliuned:DptoPSIBIO-FPSI-Articulos-Pcollado-0005
DOI - identifier https://doi.org/10.1016/j.neuroscience.2019.11.008
ISSN - identifier 1873-7544, 0306-4522
Nombre de la revista Neuroscience
Número de Volumen 426
Página inicial 59
Página final 68
Publicado en la Revista Neuroscience 426 (2020) 59–68
Idioma eng
Versión de la publicación publishedVersion
Tipo de recurso Article
Derechos de acceso y licencia http://creativecommons.org/licenses/by-nc-nd/4.0
Tipo de acceso Acceso abierto
Notas adicionales The registered version of this article, first published in Neuroscience, is available online at the publisher's website: https://doi.org/10.1016/j.neuroscience.2019.11.008
Notas adicionales La versión registrada de este artículo, publicado por primera vez en Neuroscience, está disponible en línea en el sitio web del editor: https://doi.org/10.1016/j.neuroscience.2019.11.008

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Creado: Wed, 31 Jan 2024, 01:36:44 CET