G Protein-Coupled Estrogen Receptor Immunoreactivity in the Rat Hypothalamus Is Widely Distributed in Neurons, Astrocytes, and Oligodendrocytes, Fluctuates during the Estrous Cycle, and Is Sexually Dimorphic

Marraudino, Marilena, Carrillo, Beatriz, Collado, Paloma y et al. . (2020) G Protein-Coupled Estrogen Receptor Immunoreactivity in the Rat Hypothalamus Is Widely Distributed in Neurons, Astrocytes, and Oligodendrocytes, Fluctuates during the Estrous Cycle, and Is Sexually Dimorphic. Neuroendocrinology 111: 660- 677 (2021)

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Título G Protein-Coupled Estrogen Receptor Immunoreactivity in the Rat Hypothalamus Is Widely Distributed in Neurons, Astrocytes, and Oligodendrocytes, Fluctuates during the Estrous Cycle, and Is Sexually Dimorphic
Autor(es) Marraudino, Marilena
Carrillo, Beatriz
Collado, Paloma
et al.
Materia(s) Psicología
Abstract Introduction: The membrane-associated G protein-coupled estrogen receptor 1 (GPER) mediates the regulation by estradiol of arginine-vasopressin immunoreactivity in the supraoptic and paraventricular hypothalamic nuclei of female rats and is involved in the estrogenic control of hypothalamic regulated functions, such as food intake, sexual receptivity, and lordosis behavior. Objective: To assess GPER distribution in the rat hypothalamus. Methods: GPER immunoreactivity was assessed in different anatomical subdivisions of five selected hypothalamic regions of young adult male and cycling female rats: the arcuate nucleus, the lateral hypothalamus, the paraventricular nucleus, the supraoptic nucleus, and the ventromedial hypothalamic nucleus. GPER immunoreactivity was colocalized with NeuN as a marker of mature neurons, GFAP as a marker of astrocytes, and CC1 as a marker of mature oligodendrocytes. Results: GPER immunoreactivity was detected in hypothalamic neurons, astrocytes, and oligodendrocytes. Sex and regional differences and changes during the estrous cycle were detected in the total number of GPER-immunoreactive cells and in the proportion of neurons, astrocytes, and oligodendrocytes that were GPER-immunoreactive. Conclusions: These findings suggest that estrogenic regulation of hypothalamic function through GPER may be different in males and females and may fluctuate during the estrous cycle in females.
Palabras clave Arcuate nucleus
Lateral hypothalamus
Paraventricular nucleus
Supraoptic nucleus
Ventromedial hypothalamus
Editor(es) S. Karger AG
Fecha 2020
Formato application/pdf
Identificador bibliuned:DptoPSIBIO-FPSI-Articulos-Pcollado-0004
http://e-spacio.uned.es/fez/view/bibliuned:DptoPSIBIO-FPSI-Articulos-Pcollado-0004
DOI - identifier https://doi.org/10.1159/000509583
ISSN - identifier 0028-3835, eISSN 1423-0194
Nombre de la revista Neuroendocrinology
Número de Volumen 111
Número de Issue 7
Página inicial 660
Página final 677
Publicado en la Revista Neuroendocrinology 111: 660- 677 (2021)
Idioma eng
Versión de la publicación publishedVersion
Tipo de recurso Article
Notas adicionales The registered version of this article, first published in Neuroendocrinology, is available online at the publisher's website: S. Karger AG, https://doi.org/10.1159/000509583
Notas adicionales La versión registrada de este artículo, publicado por primera vez en Neuroendocrinology, está disponible en línea en el sitio web del editor: S. Karger AG, https://doi.org/10.1159/000509583

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Creado: Fri, 26 Jan 2024, 22:47:49 CET