Genistein during Development Alters Differentially the Expression of POMC in Male and Female Rats

Fernandez-Garcia, Jose Manuel, Carrillo, Beatriz, Tezanos, Patricia, Collado, Paloma y Pinos, Helena . (2021) Genistein during Development Alters Differentially the Expression of POMC in Male and Female Rats. Metabolites 2021, 11, 293

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Título Genistein during Development Alters Differentially the Expression of POMC in Male and Female Rats
Autor(es) Fernandez-Garcia, Jose Manuel
Carrillo, Beatriz
Tezanos, Patricia
Collado, Paloma
Pinos, Helena
Materia(s) Psicología
Abstract Phytoestrogens are considered beneficial for health, but some studies have shown that they may cause adverse effects. This study investigated the effects of genistein administration during the second week of life on energy metabolism and on the circuits regulating food intake. Two different genistein doses, 10 or 50 g/g, were administered to male and female rats from postnatal day (P) 6 to P13. Physiological parameters, such as body weight and caloric intake, were then analyzed at P90. Moreover, proopiomelanocortin (POMC) expression in the arcuate nucleus (Arc) and orexin expression in the dorsomedial hypothalamus (DMH), perifornical area (PF) and lateral hypothalamus (LH) were studied. Our results showed a delay in the emergence of sex differences in the body weight in the groups with higher genistein doses. Furthermore, a significant decrease in the number of POMC-immunoreactive (POMC-ir) cells in the Arc in the two groups of females treated with genistein was observed. In contrast, no alteration in orexin expression was detected in any of the structures analyzed in either males or females. In conclusion, genistein can modulate estradiol’s programming actions on the hypothalamic feeding circuits differentially in male and female rats during development.
Palabras clave genistein
proopiomelanocortin
arcuate nucleus
sex differences
rats
Editor(es) MDPI
Fecha 2021
Formato application/pdf
Identificador bibliuned:DptoPSIBIO-FPSI-Articulos-Pcollado-0002
http://e-spacio.uned.es/fez/view/bibliuned:DptoPSIBIO-FPSI-Articulos-Pcollado-0002
DOI - identifier https://doi.org/10.3390/metabo11050293
ISSN - identifier 2218-1989
Nombre de la revista Metabolites
Número de Volumen 11
Publicado en la Revista Metabolites 2021, 11, 293
Idioma eng
Versión de la publicación publishedVersion
Tipo de recurso Article
Derechos de acceso y licencia http://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
Tipo de acceso Acceso abierto
Notas adicionales The registered version of this article, first published in Metabolites , is available online at the publisher's website: MDPI, https://doi.org/10.3390/metabo11050293
Notas adicionales La versión registrada de este artículo, publicado por primera vez en Metabolites , está disponible en línea en el sitio web del editor: MDPI, https://doi.org/10.3390/metabo11050293

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Creado: Fri, 26 Jan 2024, 21:58:11 CET