Activity-based anorexia alters hypothalamic POMC and orexin populations in male rats

Pinos, Helena, Sánchez-Serrano, Ricardo, Collado, Paloma y et al. . (2023) Activity-based anorexia alters hypothalamic POMC and orexin populations in male rats. Behavioural Brain Research 436 (2023) 114055

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Título Activity-based anorexia alters hypothalamic POMC and orexin populations in male rats
Autor(es) Pinos, Helena
Sánchez-Serrano, Ricardo
Collado, Paloma
et al.
Materia(s) Psicología
Abstract The objective of this study was to investigate the orexin and POMC populations in the hypothalamic nuclei of male Wistar rats after the activity-based anorexia (ABA) procedure. Four groups were established based on food restriction and activity: activity (A), ABA, diet (D) and control (C). The ABA protocol consisted of free access to a running wheel for a period of 22 h and access to food for 1 h. When the animals in the ABA group reached the ABA criterion, were sacrificed, and their brains were collected and serially sectioned. The free-floating sections were processed for orexin and POMC immunostaining. The number of orexin A-ir cells in the perifornicaldorsomedial- hypothalamus continuum (PFD) and lateral hypothalamus (LH) and the number of POMC-ir cells in the arcuate nucleus (Arc) were estimated. Data on food intake, body weight and wheel turns were also analyzed. The ABA procedure caused a significant decrease in body weight along with a significant increase in activity. Moreover, at the end of the ABA procedure, the number of POMC-ir cells decreased in the Arc in the A group, and significantly more in the ABA group, and the number of orexin A-ir positive cells decreased in the LH in D and ABA groups. The differential decrease in POMC in the ABA group emphasizes the importance of the melanocortin system in the maintenance of ABA, but more research is needed to elucidate the involvement of this peptide in the mechanism that promotes and maintains anorexia nervosa and how increased activity may interact with all these processes.
Editor(es) Elsevier
Fecha 2023
Formato application/pdf
Identificador bibliuned:DptoPSIBIO-FPSI-Articulos-Pcollado-0001
http://e-spacio.uned.es/fez/view/bibliuned:DptoPSIBIO-FPSI-Articulos-Pcollado-0001
DOI - identifier https://doi.org/10.1016/j.bbr.2022.114055
ISSN - identifier 0166-4328
Nombre de la revista Behavioural Brain Research
Número de Volumen 436
Publicado en la Revista Behavioural Brain Research 436 (2023) 114055
Idioma eng
Versión de la publicación publishedVersion
Tipo de recurso Article
Derechos de acceso y licencia http://creativecommons.org/licenses/by-nc-nd/4.0
info:eu-repo/semantics/openAccess
Tipo de acceso Acceso abierto
Notas adicionales The registered version of this article, first published in Behavioural Brain Research, is available online at the publisher's website: Elsevier, https://doi.org/10.1016/j.bbr.2022.114055
Notas adicionales La versión registrada de este artículo, publicado por primera vez en Behavioural Brain Research, está disponible en línea en el sitio web del editor: Elsevier, https://doi.org/10.1016/j.bbr.2022.114055

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Creado: Fri, 26 Jan 2024, 21:31:34 CET