Δ 9-Tetrahydrocannabinol during adolescence reprograms the nucleus accumbens transcriptome, affecting reward processing, impulsivity, and specific aspects of cocaine addiction-like behavior in a sex-dependent manner

Orihuel, Javier, Capellán, Roberto, Ucha, Marcos y et al. . (2021) Δ 9-Tetrahydrocannabinol during adolescence reprograms the nucleus accumbens transcriptome, affecting reward processing, impulsivity, and specific aspects of cocaine addiction-like behavior in a sex-dependent manner. International Journal of Neuropsychopharmacology, Volume 24, Issue 11, November 2021, Pages 920–933

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Título Δ 9-Tetrahydrocannabinol during adolescence reprograms the nucleus accumbens transcriptome, affecting reward processing, impulsivity, and specific aspects of cocaine addiction-like behavior in a sex-dependent manner
Autor(es) Orihuel, Javier
Capellán, Roberto
Ucha, Marcos
et al.
Materia(s) Psicología
Abstract Background: Cannabis exposure during adolescence is associated with emotional and motivational alterations that may entail an enhanced risk of developing psychiatric disorders. In rodent models, exposure to cannabinoids during adolescence leads to increased self-administration of opiates and cocaine, however, the psychological and neural mechanisms and the sex-specificity of this phenomenon are largely unknown. Methods: We exposed male and female adolescent rats to Δ9-tetrahydrocannabinol (THC) and studied at adulthood the effects of such treatment on psychological processes related to reward, such as Pavlovian conditioned approach, Pavlovian to instrumental transfer, habit formation and waiting impulsivity. In the light of these data and given the involvement of the nucleus accumbens in the processes examined, we performed an RNASeq transcriptomic study and assessed cocaine addiction-like behavior. Results: THC exposure increased goal-tracking (in males and females) and enhanced Pavlovian to instrumental transfer (especially in males) but did not affect habit formation. THC-exposed rats exhibited subtle, state-dependent changes in premature responding in the 2-CSRTT task. RNASeq data showed gene expression alterations in a marked sex-specific manner. While no effects were found on the acquisition of cocaine self-administration or punished drug-seeking, rats exposed to THC self-administered more cocaine under a progressive ratio schedule (males), had a higher rebound upon returning to continuous access to the drug (females) and showed reduced drug-seeking after 30 days of withdrawal (females). Conclusions: Adolescent THC affects specific aspects of reward- (and cocaine-) guided behavior and the function of a key brain region mediating these effects, in a remarkable sex-specific manner.
Palabras clave cannabis
cocaine
Gateway Hypothesis
reward
RNAseq
Editor(es) Oxford Academic
Fecha 2021
Formato application/pdf
Identificador bibliuned:DptoPSIBIO-FPSI-Articulos-Mucha-0007
http://e-spacio.uned.es/fez/view/bibliuned:DptoPSIBIO-FPSI-Articulos-Mucha-0007
DOI - identifier https://doi.org/10.1093/ijnp/pyab058
ISSN - identifier 1469-5111, 1461-1457
Nombre de la revista International Journal of Neuropsychopharmacology
Número de Volumen 24
Número de Issue 11
Página inicial 920
Página final 933
Publicado en la Revista International Journal of Neuropsychopharmacology, Volume 24, Issue 11, November 2021, Pages 920–933
Idioma eng
Versión de la publicación publishedVersion
Tipo de recurso Article
Derechos de acceso y licencia http://creativecommons.org/licenses/by-nc/4.0
info:eu-repo/semantics/openAccess
Tipo de acceso Acceso abierto
Notas adicionales The registered version of this article, first published in International Journal of Neuropsychopharmacology, is available online at the publisher's website: Oxford Academic, https://doi.org/10.1093/ijnp/pyab058
Notas adicionales La versión registrada de este artículo, publicado por primera vez en Journal of Psychopharmacology, está disponible en línea en el sitio web del editor: Oxford Academic, https://doi.org/10.1093/ijnp/pyab058

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Creado: Wed, 31 Jan 2024, 23:17:10 CET