Morphine self-administration alters the expression of translational machinery genes in the amygdala of male Lewis rats

Ucha, Marcos, Coria, Santiago M., Núñez, Adrián E. y et al. . (2019) Morphine self-administration alters the expression of translational machinery genes in the amygdala of male Lewis rats. Journal of Psychopharmacology, 33 (7) Pág.882-893

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Título Morphine self-administration alters the expression of translational machinery genes in the amygdala of male Lewis rats
Autor(es) Ucha, Marcos
Coria, Santiago M.
Núñez, Adrián E.
et al.
Materia(s) Psicología
Abstract Background: Addiction is a chronic disorder with a high risk of relapse. The neural mechanisms mediating addictions require protein synthesis, which could be relevant for the development of more effective treatments. The mTOR signaling pathway regulates protein synthesis processes that have recently been linked to the development of drug addiction. Aims: To assess the effects of morphine self-administration and its subsequent extinction on the expression of several genes that act in this pathway, and on the levels of specific phosphoproteins (Akt, Gsk3α/β, mTOR, PDK1 and p70 S6 kinase) in the amygdala, nucleus accumbens, and the prefrontal cortex. Methods: Male Lewis rats underwent morphine self-administration (1 mg/kg) for 19 days. They subsequently were submitted to extinction training for 15 days. Rats were killed either after self-administration or extinction, their brains extracted, and gene expression or phosphoprotein levels were assessed. Results: We found an increase in Raptor and Eif4ebp2 expression in the amygdala of rats that self-administered morphine, even after extinction. The expression of Insr in the amygdala of control animals decreased over time while the opposite effect was seen in the rats that self-administered morphine. Conclusions: Our results suggest that morphine self-administration affects the gene expression of some elements of the translational machinery in the amygdala.
Palabras clave Morphine self-administration
Lewis rats
mTOR pathway
extinction
protein synthesis
Editor(es) SAGE Publications
Fecha 2019
Formato application/pdf
Identificador bibliuned:DptoPSIBIO-FPSI-Articulos-Mucha-0005
http://e-spacio.uned.es/fez/view/bibliuned:DptoPSIBIO-FPSI-Articulos-Mucha-0005
DOI - identifier https://doi.org/10.1177/0269881119836206
ISSN - identifier 0269-8811, eISSN 1461-7285
Nombre de la revista Journal of Psychopharmacology
Número de Volumen 33
Número de Issue 7
Página inicial 882
Página final 893
Publicado en la Revista Journal of Psychopharmacology, 33 (7) Pág.882-893
Idioma eng
Versión de la publicación publishedVersion
Tipo de recurso Article
Derechos de acceso y licencia http://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
Tipo de acceso Acceso abierto
Notas adicionales The registered version of this article, first published in Journal of Psychopharmacology, is available online at the publisher's website: SAGE Publications, https://doi.org/10.1177/0269881119836206
Notas adicionales La versión registrada de este artículo, publicado por primera vez en Journal of Psychopharmacology, está disponible en línea en el sitio web del editor: SAGE Publications, https://doi.org/10.1177/0269881119836206

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Creado: Wed, 31 Jan 2024, 22:35:04 CET