Impulsive Action and Impulsive Choice Are Differentially Associated With Gene Expression Variations of the GABAA Receptor Alfa 1 Subunit and the CB1 Receptor in the Lateral and Medial Orbitofrontal Cortices

Ucha, Marcos, Roura-Martínez, David, Contreras, Ana y et al. . (2019) Impulsive Action and Impulsive Choice Are Differentially Associated With Gene Expression Variations of the GABAA Receptor Alfa 1 Subunit and the CB1 Receptor in the Lateral and Medial Orbitofrontal Cortices. Frontiers in Behavioral Neuroscience, Volume 13 - 2019

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Título Impulsive Action and Impulsive Choice Are Differentially Associated With Gene Expression Variations of the GABAA Receptor Alfa 1 Subunit and the CB1 Receptor in the Lateral and Medial Orbitofrontal Cortices
Autor(es) Ucha, Marcos
Roura-Martínez, David
Contreras, Ana
et al.
Materia(s) Psicología
Abstract The orbitofrontal cortex (OFC) is a key brain region for decision-making, action control and impulsivity. Quite notably, previous research has identified a double dissociation regarding the role of this cortical territory in impulsive choice. While medial orbitofrontal lesions increase preference for a large but delayed reward, lateral orbitofrontal lesions have the opposite effect. However, there are no data regarding this anatomical dissociation in impulsive action. The neurochemical basis of impulsivity is still being elucidated, however, in recent years a role for the endocannabinoids and the related glutamatergic and GABAergic neurotransmitter systems has been suggested. Here, we submitted male Wistar rats to a delay-discounting task (DDT) or a two-choice serial reaction time task (2-CSRTT) and classified them as high impulsive or low impulsive in either task using cluster analysis. We then examined the gene expression of several elements of the endocannabinoid system or different subunits of certain glutamatergic or GABAergic ionotropic receptors (AMPA, NMDA, or GABAA) in the lateral or medial divisions of their orbitofrontal cortices. Our results confirm, at the gene expression level, the dissociation in the participation of the medial, and lateral divisions of the orbitofrontal cortex in impulsivity. While in the 2-CSRTT (inhibitory control) we found that high impulsive animals exhibited lower gene expression levels of the a1 GABAA receptor subunit in the lateral OFC, no such differences were evident in the medial OFC. When we analyzed DDT performance, we found that high impulsive animals displayed lower levels of CB1 gene expression in the medial but not in the lateral OFC. We propose that GABAergic dynamics in the lateral OFC might contribute to the inhibitory control mechanisms that are altered in impulsive behavior while endocannabinoid receptor gene transcription in the medial OFC may subserve the delay-discounting processes that participate in certain types of impulsiveness.
Palabras clave impulsivity
orbitofrontal cortex
delay-discounting
two-choice serial reaction time task
inhibitory control
ionotropic receptors
GABA
endocannabinoid system
Editor(es) Frontiers
Fecha 2019-02-20
Formato application/pdf
Identificador bibliuned:DptoPSIBIO-FPSI-Articulos-Mucha-0004
http://e-spacio.uned.es/fez/view/bibliuned:DptoPSIBIO-FPSI-Articulos-Mucha-0004
DOI - identifier https://doi.org/10.3389/fnbeh.2019.00022
ISSN - identifier 1662-5153
Nombre de la revista Frontiers in Behavioral Neuroscience
Número de Volumen 13
Publicado en la Revista Frontiers in Behavioral Neuroscience, Volume 13 - 2019
Versión de la publicación publishedVersion
Tipo de recurso Article
Derechos de acceso y licencia http://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
Tipo de acceso Acceso abierto
Notas adicionales The registered version of this article, first published in Frontiers in Behavioral Neuroscience, is available online at the publisher's website: Frontiers, https://doi.org/10.3389/fnbeh.2019.00022
Notas adicionales La versión registrada de este artículo, publicado por primera vez en Frontiers in Behavioral Neuroscience, está disponible en línea en el sitio web del editor: Frontiers, https://doi.org/10.3389/fnbeh.2019.00022

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Creado: Wed, 31 Jan 2024, 22:10:43 CET