Comparative analysis of the modulation of perineuronal nets in the prefrontal cortex of rats during protracted withdrawal from cocaine, heroin and sucrose self-administration

Roura-Martínez, David, Díaz-Bejarano, Paula, Ucha, Marcos y et al. . (2020) Comparative analysis of the modulation of perineuronal nets in the prefrontal cortex of rats during protracted withdrawal from cocaine, heroin and sucrose self-administration. Neuropharmacology 180 (2020) 108290

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Título Comparative analysis of the modulation of perineuronal nets in the prefrontal cortex of rats during protracted withdrawal from cocaine, heroin and sucrose self-administration
Autor(es) Roura-Martínez, David
Díaz-Bejarano, Paula
Ucha, Marcos
et al.
Materia(s) Psicología
Abstract Relapse into drug use is a significant problem for people recovering from addiction. The ability that conditioned cues have to reinstate and reinvigorate drug-seeking is potentiated over time (incubation of seeking), posing an additional difficulty for maintaining abstinence. While the prefrontal cortex has been involved in the incubation phenomenon and the extracellular matrix, perineuronal nets (PNNs) in particular, may play a vital role in brain plasticity associated to drug relapse, there are no comparative analyses between different drug classes and natural reinforcers. Here, we compare the effects of early (1 day) and protracted (30 days) withdrawal from to cocaine, heroin and sucrose self-administration on the total density and density per intensity range of PNNs of different territories of the prefrontal cortex of male Lewis rats. Our results show that cocaine self-administration increases the density of PNNs in the dorsal prelimbic, infralimbic and ventral orbitofrontal cortices, while protracted withdrawal reversesthis effect in the dorsal prelimbic cortex. Also, heroin self-administration increases the density of PNNs in the infralimbic cortex and ventral orbitofrontal cortices, but this effect is lost after 30 days of withdrawal in the infralimbic cortex. Finally, the self-administration of sucrose-sweetened water or the protracted withdrawal from this powerful reinforcer does not affect any of the PNN parameters analysed. Our results show that two different drugs of abuse (but not a natural reward) with specific pharmacological and physiological actions, differentially modulate PNNs in specific areas of the rodent prefrontal cortex with potential implications for the incubation of seeking phenomenon.
Palabras clave Cocaine
Heroin
Natural rewards
Perineuronal nets
Prefrontal cortex
Editor(es) Elsevier
Fecha 2020
Formato application/pdf
Identificador bibliuned:DptoPSIBIO-FPSI-Articulos-Mucha-0002
http://e-spacio.uned.es/fez/view/bibliuned:DptoPSIBIO-FPSI-Articulos-Mucha-0002
DOI - identifier https://doi.org/10.1016/j.neuropharm.2020.108290
ISSN - identifier 0028-3908
Nombre de la revista Neuropharmacology
Publicado en la Revista Neuropharmacology 180 (2020) 108290
Idioma eng
Versión de la publicación publishedVersion
Tipo de recurso Article
Derechos de acceso y licencia http://creativecommons.org/licenses/by-nc-nd/4.0
info:eu-repo/semantics/openAccess
Tipo de acceso Acceso abierto
Notas adicionales The registered version of this article, first published in Neuropharmacology, is available online at the publisher's website: Elsevier, https://doi.org/10.1016/j.neuropharm.2020.108290
Notas adicionales La versión registrada de este artículo, publicado por primera vez en Neuropharmacology, está disponible en línea en el sitio web del editor: Elsevier, https://doi.org/10.1016/j.neuropharm.2020.108290

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Creado: Wed, 31 Jan 2024, 21:07:41 CET