Central nucleus of the amygdala as a common substrate of the incubation of drug and natural reinforcer seeking

Roura‐Martínez, David, Ucha, Marcos, Orihuel, Javier y et al. . (2019) Central nucleus of the amygdala as a common substrate of the incubation of drug and natural reinforcer seeking. Addiction Biology. 2019;1–12

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Título Central nucleus of the amygdala as a common substrate of the incubation of drug and natural reinforcer seeking
Autor(es) Roura‐Martínez, David
Ucha, Marcos
Orihuel, Javier
et al.
Materia(s) Psicología
Abstract Relapse into drug use is a major problem faced by recovering addicts. In humans, an intensification of the desire for the drug induced by environmental cues—incubation of drug craving—has been observed. In rodents, this phenomenon has been modeled by studying drug seeking under extinction after different times of drug withdrawal (or using a natural reinforcer). Although much progress has been made, an integrated approach simultaneously studying different drug classes and natural reward and examining different brain regions is lacking. Lewis rats were used to study the effects of cocaine, heroin, and sucrose seeking incubation on six key brain regions: the nucleus accumbens shell/core, central/basolateral amygdala, and dorsomedial/ventromedial prefrontal cortex. We analyzed PSD95 and gephyrin protein levels, gene expression of glutamatergic, GABAergic and endocannabinoid elements, and amino acid transmitter levels. The relationships between the areas studied were examined by Structural Equation Modelling. Pathways from medial prefrontal cortex and basolateral complex of the amygdala to central nucleus of the amygdala, but not to the nucleus accumbens, were identified as common elements involved in the incubation phenomenon for different substances. These results suggest a key role for the central nucleus of amygdala and its cortical and amygdalar afferences in the incubation phenomenon, and we suggest that by virtue of its regulatory effects on glutamatergic and GABAergic dynamics within amygdalar circuits, the endocannabinoid system might be a potential target to develop medications that are effective in the context of relapse.
Palabras clave central nucleus of the amygdala,
drugs of abuse,
endocannabinoid system,
incubation of seeking,
natural rewards,
nucleus accumbens
Editor(es) WILEY
Fecha 2019
Formato application/pdf
Identificador bibliuned:DptoPSIBIO-FPSI-Articulos-Mucha-0001
DOI - identifier https://doi.org/10.1111/adb.12706
ISSN - identifier 1369-1600, 1355-6215
Nombre de la revista Addiction Biology
Página inicial 1
Página final 12
Publicado en la Revista Addiction Biology. 2019;1–12
Idioma eng
Versión de la publicación publishedVersion
Tipo de recurso Article
Derechos de acceso y licencia http://creativecommons.org/licenses/by-nc-nd/4.0
Tipo de acceso Acceso abierto
Notas adicionales The registered version of this article, first published in Addiction Biology, is available online at the publisher's website: WILEY, https://doi.org/10.1111/adb.12706
Notas adicionales La versión registrada de este artículo, publicado por primera vez en Addiction Biology, está disponible en línea en el sitio web del editor: WILEY, https://doi.org/10.1111/adb.12706

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Creado: Wed, 31 Jan 2024, 20:40:49 CET