Exposure to increased levels of estradiol during development can have long-term effects on the response to undernutrition in female rats

Carrillo, Beatriz, Collado, Paloma, Díaz, Francisca, Chowen, Julie A y Pinos, Helena . (2016) Exposure to increased levels of estradiol during development can have long-term effects on the response to undernutrition in female rats. Nutritional Neuroscience

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Título Exposure to increased levels of estradiol during development can have long-term effects on the response to undernutrition in female rats
Autor(es) Carrillo, Beatriz
Collado, Paloma
Díaz, Francisca
Chowen, Julie A
Pinos, Helena
Materia(s) Biología
Psicología
Abstract Objectives: Undernutrition during development alters the expression of peptides that control energy expenditure and feeding behavior. Estrogens can also modulate these peptides. Here we analyzed whether early postnatal administration of estradiol modulates the effects of undernutrition on neuroendocrine parameters in adult female Wistar rats. Methods: Control rats were fed a control diet. Undernourished pups were submitted to a restricted diet with half of the undernourished rats receiving 0.4 mg/kg s.c. of estradiol benzoate (EB) from postnatal day (P) 6 until P13. Quantitative real-time PCR was performed to determine expression in the hypothalamus of Agouti-related peptide (AgRP), proopiomelanocortin (POMC), neuropeptide Y (NPY) and cocaine- and amphetamine-regulated transcript (CART). Plasma estradiol, testosterone and adiponectin levels were measured by ELISA. Total and acylated ghrelin levels were measured in plasma by RIA. Results: Undernourishment decreased body weight, fat mass, plasma leptin and insulin levels and hypothalamic POMC mRNA levels. An increase in orexigenic signals AgRP and NPY mRNA levels, and in plasma adiponectin levels were found in undernourished animals. Early postnatal treatment with EB to undernourished female rats reversed the effects of undernutrition on adult hypothalamic POMC mRNA levels. In addition, neonatal EB treatment to undernourished females significantly decreased adult plasma testosterone, estradiol and acylated ghrelin levels. Discussion: Our results suggest that increased estradiol during a critical period of development has the capacity to modulate the alterations that undernutrition produces on energy metabolism.
Palabras clave Protein restriction
Estradiol
Orexinergic and anorexinergic neuropeptides
Metabolic factors
PCR
Rat
Editor(es) Taylor and Francis Group
Fecha 2016-11
Formato application/pdf
Identificador bibliuned:DptoPSIBIO-FPSI-Articulos-Mepinos-0002
http://e-spacio.uned.es/fez/view/bibliuned:DptoPSIBIO-FPSI-Articulos-Mepinos-0002
DOI - identifier https://doi.org/10.1179/1476830515Y.0000000012
ISSN - identifier 1476-8305
Nombre de la revista Nutritional Neuroscience
Número de Volumen 19
Número de Issue 9
Publicado en la Revista Nutritional Neuroscience
Idioma eng
Versión de la publicación draft
Tipo de recurso Article
Derechos de acceso y licencia http://creativecommons.org/licenses/by-nc-nd/4.0
info:eu-repo/semantics/openAccess
Tipo de acceso Acceso abierto
Notas adicionales La versión registrada de este artículo, publicado por primera vez en Nutritional Neuroscience (2016) 19 9, está disponible en línea en el sitio web del editor: Taylor and Francis Group, https://doi.org/10.1179/1476830515Y.0000000012
Notas adicionales The registered version of this paper, first published in Nutritional Neuroscience (2016)199, is available online at the publisher's website: Taylor and Francis Group, https://doi.org/10.1179/1476830515Y.0000000012

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Creado: Wed, 20 Mar 2024, 20:16:06 CET